A5066708660- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Neuroscience and Neural Engineering
- Hearing, Cochlea, Tinnitus, Genetics
- Epilepsy research and treatment
- Hip disorders and treatments
- Orthopaedic implants and arthroplasty
- Anesthesia and Neurotoxicity Research
- Polyamine Metabolism and Applications
- Signaling Pathways in Disease
- BRCA gene mutations in cancer
- Cardiac electrophysiology and arrhythmias
- Amino Acid Enzymes and Metabolism
- Neuroscience, Education and Cognitive Function
- Bone Tissue Engineering Materials
- Connexins and lens biology
- Ion Transport and Channel Regulation
- Gene expression and cancer classification
- Mast cells and histamine
University of Puerto Rico at Aguadilla
2018-2024
Central University of the Caribbean
2015-2022
Antillean Adventist University
2020-2022
Instituto Politécnico Nacional
2004
Centro de Estudios Universitarios Adolfo López Mateos
2004
Epilepsy, characterized by recurrent seizures, affects 1% of the general population. Interestingly, 25% diabetics develop seizures with a yet unknown mechanism. Hyperglycemia downregulates inwardly rectifying potassium channel 4.1 (Kir4.1) in cultured astrocytes. Therefore, present study aims to determine if downregulation functional astrocytic Kir4.1 channels occurs brains type 2 diabetic mice and could influence hippocampal neuronal hyperexcitability. Using whole-cell patch clamp recording...
Endogenous anticonvulsant mechanisms represent a reliable and currently underdeveloped strategy against recurrent seizures may recall novel original therapeutics. Here, we investigated whether the intensification of astroglial Glu-GABA exchange mechanism by application GABA precursor putrescine (PUT) be effective convulsive non-convulsive seizures. We explored potential PUT to inhibit spontaneous spike-and-wave discharges (SWDs) in WAG/Rij rats, genetic model absence epilepsy. Significant...
Polyamine (PA) spermidine (SPD) plays a crucial role in aging. Since SPD accumulates glial cells, particularly Müller retinal cells (MCs), the expression of SPD-synthesizing enzyme synthase (SpdS) glia and age-dependent SpdS activity are not known. We used immunocytochemistry, Western blot (WB), image analysis on rat retinae at postnatal days 3, 21, 120. The anti-glutamine synthetase (GS) antibody was to identify cells. In neonatal retina (postnatal day 3 (P3)), expressed almost all...
Protecting neurons from neurotoxicity is a job mainly performed by astrocytes through glutamate uptake and potassium buffering. These functions are aided principally the Kir4.1 inwardly rectifying channels located in membrane of astrocytes. Astrocytes grown hyperglycemic conditions have decreased levels as well impaired uptake. Previous studies human corneal epithelial cell injury model demonstrated mechanism regulation expression via binding microRNA-250 (miR-205) to 3´ untranslated region....
Puerto Rico is in dire need of transforming its education system to counter the current economic recession and ensure a future with talented Ricans at forefront scientific research technology development. Here we present group neuroscientists educators, NeuroBoricuas, committed revolutionize culture by incorporating neuroscience training inquiry-based activities public private schools. We carry out our vision through diverse methods, such as community outreach activities, where promote...
The interest in astrocytes, the silent brain cells that accumulate polyamines (PAs), is growing. PAs exert anti-inflammatory, antioxidant, antidepressant, neuroprotective, and other beneficial effects, including increasing longevity vivo. Unlike neurons, astrocytes are extensively coupled to others via connexin (Cx) gap junctions (GJs). Although there striking modulatory effects of on neuronal receptors channels, PA regulation astrocytic GJs not well understood. We studied GJ-propagation...
Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Twitter Facebook Reddit LinkedIn Tools Reprints and Permissions Cite Search Site Citation M. Méndez‐González; Preparation of Porous Hydroxyapatite Tablets Coatings for Orthopaedic Use. AIP Conf. Proc. 30 September 2004; 724 (1): 262–264. https://doi.org/10.1063/1.1811863 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search...
Over the last 20 years, there has been an explosion of genomic data collected for disease association, functional analyses, and other large-scale discoveries. At same time, have revolutions in cloud computing that enable computational science research, while making accessible to anyone with a web browser internet connection. However, students at institutions limited resources received relatively little exposure curricula or professional development opportunities lead careers science. To...