A5005822997- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Dermatological and COVID-19 studies
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetic Foot Ulcer Assessment and Management
- Inflammasome and immune disorders
- Health and Medical Education
- Medical and Biological Ozone Research
- IL-33, ST2, and ILC Pathways
- Shoulder and Clavicle Injuries
- Traumatic Ocular and Foreign Body Injuries
- Trauma Management and Diagnosis
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2021-2025
The intramuscular administration of polymerized type I collagen (PTIC) for adult symptomatic COVID-19 outpatients downregulated hyperinflammation and improved symptoms. We inferred that LAIR1 is a potential receptor PTIC. Thus, binding assay surface plasmon resonance were performed to estimate the affinity interaction between M1 macrophages derived from THP-1 cells cultured with 2–10% PTIC 24 h. Lysates PTIC-treated cells, macrophage-like (MLCs), M1, + IFN-γ, LPS analyzed by Western blot...
Abstract Background The polymerized type I collagen (PTIC) is a γ-irradiated mixture of pepsinized porcine and polyvinylpyrrolidone (PVP). It has immunomodulatory properties. However, the receptor signaling pathway through which it exerts its therapeutic effects not yet been identified. Aim To evaluate LAIR-1 as potential for PTIC evoked by ligand-receptor binding. Methods binding assay was performed incubating various concentrations recombinant human with native or PTIC. Macrophages M1-...
The intramuscular administration of polymerized type I collagen (PTIC) for adult symptomatic COVID-19 outpatient downregulated hyperinflammation and improved symptoms. We inferred that LAIR-1 is a potential receptor PTIC. Thus, binding assay surface plasmon resonance were performed to estimate the affinity interaction between M1-macrophage derived from THP-1 cells cultured with 2-10% PTIC 24 h. Lysates PTIC-treated cells, macrophages-like (MLCs), M1, M1+IFN-γ, M1+LPS analyzed by western blot...
ABSTRACT BACKGROUND Currently, therapeutic options for ambulatory COVID-19 patients are limited. OBJECTIVE To evaluate the safety, efficacy and effect of intramuscular administration polymerized type I collagen (PTIC) on hyperinflammation, oxygen saturation symptom improvement in adult outpatients with symptomatic COVID-19. DESIGN Double-blind, randomised, placebo-controlled clinical trial PTIC vs placebo. SETTING Single Third-level hospital Mexico City (Instituto Nacional de Ciencias...
Abstract Background Currently, therapeutic options for outpatients with COVID-19 are limited, in Mexico Polymerized Collagen type I (PCTI) has been tested as a useful option. Methods Double-blind, randomised, placebo-controlled clinical trial of PTIC vs placebo. To evaluate the safety, efficacy and effect intramuscular administration polymerized collagen (PTIC) on hyperinflammation, oxygen saturation symptom improvement adult symptomatic COVID-19. Eighty-nine participants confirmed diagnosis...