A5056488609- Muscle metabolism and nutrition
- Sports Performance and Training
- Exercise and Physiological Responses
- Occupational Health and Performance
- Bone health and osteoporosis research
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Physical Performance
- Adipose Tissue and Metabolism
- Body Composition Measurement Techniques
- Sports injuries and prevention
- Bone fractures and treatments
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Hormonal and reproductive studies
- Children's Physical and Motor Development
- Cardiovascular and exercise physiology
- High Altitude and Hypoxia
- Musculoskeletal Disorders and Rehabilitation
- Neuroendocrine regulation and behavior
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Pharmacological Effects and Assays
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Winter Sports Injuries and Performance
U.S. Army Research Institute of Environmental Medicine
2016-2025
United States Army
2013-2024
Beth Israel Deaconess Medical Center
2016
Harvard University
2016
Massachusetts General Hospital
2016
University of Connecticut
2006-2013
Springfield College
1989-2013
University of South Carolina
2013
University of Rhode Island
2013
Rutgers, The State University of New Jersey
2011
Due to current operational requirements, elite soldiers deploy quickly after completing arduous training courses. Therefore, it is imperative that endocrine and inflammatory mediators have fully recovered.Our objective was determine whether a short-term (2-6 wk) recovery period sufficient restore homeostasis sustained energy deficit.Before immediately the course, serum concentrations of markers were taken along with anthropometric measures prior Army Ranger course. In addition, nine assessed...
Injuries were recorded during and up to 12 days after a maximal effort road march. Light infantry soldiers (N = 335) carried total load of 46 kg over 20 km course. Twenty-four percent the suffered one or more injuries, resulting in 44 limited duty. All injuries involved lower extremities and/or back. Foot blisters back problems most common complaints (35% 23%, respectively, injuries). These data indicate that units without recent marching training can expect high incidence as result single demanding
This study examined the effects of short-term physical training on acute hormonal response (i.e., growth hormone, total and free insulin-like factor I [IGF-I], IGF binding proteins [IGFBP]-1, IGFBP-2, IGFBP-3) to resistance exercise (RE) in women.Forty-six women (20.3 ± 0.3 yr, mass = 64.1 7.3 kg, height 165.7 1.0 cm) were randomly assigned an endurance (E), (R), combined (R + E), or control (C) group for 8wk. Subjects completed a standardized bout RE (six sets back squats at 10 repetition...
Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently consumed by athletes to manage muscle soreness, expedite recovery, or improve performance. Despite the prevalence of NSAID use, their effects on soreness and performance, particularly when administered prophylactically, remain unclear. This randomized, double-blind, counter-balanced, crossover study examined effect consuming a single dose each three NSAIDs (celecoxib, 200 mg; ibuprofen, 800 flurbiprofen, 100 mg) placebo 2 h before...
This study examined the validity of an anthropometric estimate thigh muscle cross-sectional area using magnetic resonance imaging (MRI). The model assumed that a cross section could be represented as circle with concentric circular layers fat-plus-skin, muscle, and bone tissue. On 18 healthy, active men women (mean +/- SD age = 23 5 yr), total circumference (CT) was measured fiberglass tape, fat-plus-skin thickness over quadriceps (SQ) calipers, distance across medial lateral femoral...
Eighty-nine soldiers performed a maximal effort 20-km road march, carrying total load of 46 kg. Compared to pre-march values, post-march marksmanship accuracy decreased 26% for number target hits and 33% distance from the centroid target. Maximal grenade throw 9%, but there was no change in vertical jump height. The Profile Mood States questionnaire revealed an 82% increase self-reported fatigue 38% decrease vigor. Significant decrements some aspects military performance occur when march...
The purpose of this study was to determine the impact dietary factors and exercise-associated on response IGF-I its binding proteins (IGFBPs) during a period increased physical activity. Twenty-nine men completed 4-day ( days 1–4) baseline controlled energy balanced diet while maintaining their normal activity level followed by 7 5–11) 1,000 kcal/day increase in above levels. Two subject groups, one sedentary (Sed, mean V̇o 2peak : 39 ml·kg −1 ·min , n = 7) fit (FIT1, 56 8) intake maintain...
Basic combat training (BCT) is a physically rigorous period at the beginning of soldier's career that induces bone formation in tibia. Race and sex are determinants properties young adults but their influences on changes microarchitecture during BCT unknown. The purpose this work was to determine influence race BCT. Bone assessed distal tibia via high-resolution peripheral quantitative computed tomography end 8 weeks multiracial cohort trainees (552 female, 1053 male; mean ± standard...
STAAB, J. S., W. AGNEW, and S. F. SICONOLFI. Metabolic performance responses to uphill downhill running in distance runners. Med. Sci. Sports Exerc., Vol. 24, No. 1, pp. 124–127, 1992. Distance is slower on hilly race courses than flat even when the start finish are at same elevation, resulting equal amounts of running. The physiological mechanism limiting these not known. We examined effects uphills downhills with 11 trained male runners three 30 min self-paced competitive races a...
Insulin-like growth factor-I (IGF-I) is regulated by a number of IGF-binding proteins (IGFBPs) and proteases that influence IGF-I bioactivity. A specific kinase receptor activation assay (KIRA) has been developed determines the ability to activate quantification intracellular autophosphorylation on binding. KIRA-assessed bioactivity not utilized within context chronic exercise training paradigms. This study measured total free immunoreactive IGF-I, bioactive IGFBP-1, -2, -3 before (Pre),...
The rate of metabolic energy expenditure during locomotion (Mloco) is proportional to body weight (Wb) divided by the time each stride that a single foot contacts ground (tc) (Nature Lond. 346: 265–267, 1990). Using this knowledge, we developed an electronic contact monitor. Our objective was derive and cross-validate equation for estimation Mloco from Wb/tc. Twelve males were tested [age = 19.4 +/- 1.4 (SD) yr, Wb 78.4 8.0 kg] horizontal treadmill walking (0.89, 1.34, 1.79 m/s) running...
Previous studies have indicated that values for mechanical efficiency during cycle exercise in prepubertal subjects are similar to those adults. Few directly compared these groups, however, and earlier reports did not consider the importance of assessing at relative intensities. Nineteen boys 21 college men underwent testing determination delta (the energy required increase workload), related both absolute work load intensity (percent VO2max). No significant differences either measures were...
What is the main observation in this case? The of case report that during pregnancy there a progressive sympatho-excitation basal conditions and under stress, which offset by concurrent reduction neurovascular transduction. Strong correlations between autonomic nervous system activity sex hormones (oestrogen progesterone), vasopressin aldosterone were found. insights does it reveal? Our findings suggest hormonal surges might be associated with central sympathetic activation.The adaptations...
Basic combat training (BCT) is a period of novel physical including load carriage resulting in higher risk stress fracture compared to any other time during military service. Prior trials reported 20% reduction incidence with Ca and vitamin D (Ca + D) supplementation (2000 mg Ca, 800 IU D), greater increases tibia vBMD BCT placebo. The primary objective this randomized, double-blind, placebo-controlled trial was determine the efficacy lower dose (1000 mg/d 1000 vit on PTH, bone biomarkers...
Abstract Aerobic exercise reduces circulating ionized Ca (iCa) and increases parathyroid hormone (PTH), but the cause consequences on handling are unknown. The objective of this study was to determine effects strenuous kinetics using dual stable isotopes. Twenty-one healthy women (26.4 ± 6.7 yr) completed a randomized, crossover entailing two 6-d iterations consisting either 60 min treadmill walking at 65% VO2max wearing vest weighing 30% body weight days 1, 3, 5 (exercise [EX]), or rest...
Abstract Acetaminophen (ACE) is a widely used analgesic and antipyretic drug with various applications, from pain relief to fever reduction. Recent studies have reported equivocal effects of habitual ACE intake on exercise performance, muscle growth, risks bone health. Thus, this study aimed assess the impact 6‐week, low‐dose regimen adaptations in exercising non‐exercising rats. Nine‐week‐old Wistar rats ( n = 40) were randomized an or control (no exercise) condition without (placebo). For...
Healthy, normotensive human pregnancies are associated with striking increases in both plasma volume and vascular sympathetic nerve activity (SNA). In nonpregnant humans, volume-regulatory factors including osmolality, vasopressin, the renin-angiotensin-aldosterone system have important modulatory effects on control of outflow. We hypothesized that pregnancy would be changes relationships between SNA (measured as muscle SNA) volume-regulating factors, renin activity, arginine vasopressin...