- Neonatal Respiratory Health Research
- Cystic Fibrosis Research Advances
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Tracheal and airway disorders
- Asthma and respiratory diseases
- Child and Adolescent Health
- Respiratory and Cough-Related Research
- DNA Repair Mechanisms
- Antibiotic Resistance in Bacteria
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Delphi Technique in Research
- Smoking Behavior and Cessation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical studies and practices
- Esophageal and GI Pathology
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Carcinogens and Genotoxicity Assessment
- Folate and B Vitamins Research
- Airway Management and Intubation Techniques
Nottingham University Hospitals NHS Trust
2015-2024
Queen's Medical Centre
2012-2024
University of Liverpool
2021
Alder Hey Children's Hospital
2021
Liverpool Women's Hospital
2021
Methodist Hospital
2020
Cornell University
2020
Cigna (United States)
2020
Houston Methodist
2020
Methodist Hospital
2020
Tracheomalacia and tracheobronchomalacia may be primary abnormalities of the large airways or associated with a wide variety congenital acquired conditions. The evidence on diagnosis, classification management is scant. There no universally accepted severity. Clinical presentation includes early-onset stridor fixed wheeze, recurrent infections, brassy cough even near-death attacks, depending site severity lesion. Diagnosis usually made by flexible bronchoscopy in free-breathing child but...
We report a case of hypersensitivity pneumonitis (HP) in young person secondary to vaping. He presented with putative diagnosis asthma and required extracorporeal membrane oxygenationbecause intractable respiratory failure. developed critical illness steroid myopathy prolonged rehabilitation. Our patient fulfils diagnostic criteria for HP e-cigarettes positive exposure history, deterioration after skin prick testing, specific serum IgM antibodies against the implicated liquid raising...
Background Ataxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition children A-T. We hypothesised that A-T have progressive growth gastrostomy tube feeding (percutaneous endoscopic gastrostomy, PEG) favourable management option good nutritional outcomes. Methods Data were collected prospectively on weight, height body mass index...
Background and aims Ataxia telangiectasia (A-T) is a rare progressive, multisystem genetic disease. Families of children with ultra-rare diseases often experience significant diagnostic delays. We reviewed the process for A-T in order to identify causes delay an attempt facilitate earlier identification future. Methods A retrospective case note review 79 at National Paediatric clinic seen since May 2009. Data were collected on nature age initial symptoms, first presentation, measurement...
Bronchopulmonary dysplasia (BPD), also known as chronic lung disease of prematurity or neonatal disease, is a major cause respiratory illness in premature babies. Newborn babies survive at gestational ages 23 to 26 weeks, earlier than when BPD was first described. New mechanisms injury have therefore emerged and the clinical pathological characteristics pulmonary involvement changed.Improved intensive care unit modalities increased survival rates; overall prevalence condition, however, has...
Abstract Background/Objectives Ataxia telangiectasia (A‐T) is a multiorgan disorder with increased vulnerability to cancer. Despite this cancer risk, there are no widely accepted guidelines for surveillance in people affected by A‐T. We aimed understand the current international practice regarding A‐T and agreed‐upon approaches develop Design/Methods used consensus development method, e‐Delphi technique, comprising three rounds. Round 1 consisted of Delphi questionnaire survey that collected...
We present the case of a young man with cystic fibrosis (CF) who presented massive haemoptysis. All management options were considered and treatment tranexamic acid was commenced. discuss for patients CF presenting haemoptysis underlying evidence base.
Students of mythology will recollect that the second Labour Hercules was to fight Lernaean Hydra, a nine-headed monster with endearing habit growing two ferocious heads replace each one cut-off. Autres temps—conventional cigarettes may be on way out as legislators (although some rather reluctantly) have tightened noose, rich yield health benefits for children,1 2 but new Hydra-head vaping and other means inhaling nicotine come scene. Far from being given treatment (a burning firebrand neck...