A5101611547- Peptidase Inhibition and Analysis
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Catalytic C–H Functionalization Methods
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Alzheimer's disease research and treatments
- Protein Kinase Regulation and GTPase Signaling
- Synthesis and Characterization of Pyrroles
- Synthesis of Indole Derivatives
- Asthma and respiratory diseases
- Catalytic Cross-Coupling Reactions
- Biopolymer Synthesis and Applications
- IL-33, ST2, and ILC Pathways
- Genetics, Bioinformatics, and Biomedical Research
- DNA and Nucleic Acid Chemistry
Guangzhou Medical University
2025
Gannan Medical University
2020-2024
Abstract A facile and efficient method for the synthesis of trifluoromethylated carbinols has been developed from imidazo[1,2-a]pyridines trifluoroacetaldehyde. The direct C(sp2)–H hydroxytrifluoromethylation is successfully implemented at room temperature using HFIP as solvent through dehydrative cross-coupling process, which displays a broad substrate scope functional group tolerance. Furthermore, gram-scale synthetic transformation experiments have also demonstrated, indicate its...
Propofol, a quick‑acting systemic anesthetic agent widely used in general anesthesia, can alleviate airway T-helper 2 (TH2) inflammation. Group innate lymphoid cells (ILC2s) are newly discovered group of and play key roles allergic rhinitis (AR). We aimed to investigate the regulation ILC2s treated with propofol its possible mechanisms mouse model. An ovalbumin (OVA)-sensitized challenged model was established. Nasal lavage fluid (NLF) tissue samples were collected for detection inflammatory...
A facile, transition-metal-free, HFIP-promoted method for the synthesis of triarylmethanes through direct Friedel-Crafts reactions imidazo[1,2-a]pyridines with chlorohydrocarbon derivatives has been described, which allows efficient containing in good to satisfactory yields at room temperature. This transformation features simple operation, excellent functional group tolerance, and a broad substrate scope.
A facile and efficient method for synthesis of trifluoromethylated carbinols has been developed from imidazo[1,2-a]pyridines trifluoroacetaldehyde/ketone derivatives. The reaction proceeded well at room temperature using HFIP as solvent through dehydrative cross-coupling process. This conversion displays a broad substrate scope functional group tolerance with satisfactory to excellent yields. Furthermore, gram-scale synthetic transformation experiments have also demonstrated.