A5054737064- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neural Networks and Applications
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
Moscow Institute of Physics and Technology
2018-2025
Semenov Institute of Chemical Physics
2023-2025
Moscow Power Engineering Institute
2023
Moscow Aviation Institute
2023
ABSTRACT Movement disorders such as Parkinson's disease (PD) and cervical dystonia (CD) are associated with abnormal neuronal activity in the globus pallidus internus (GPi). Reduced firing rate presence of spiking bursts typical for CD, whereas PD is characterized by high frequency tonic activity. This research aims to identify most important pallidal parameters classify these conditions. We analysed single unit externus (GPe) (GPi) 11 CD 10 patients who underwent standard‐of‐care DBS...
<title>Abstract</title> Purpose Nonlinear single unit activity (SUA) characteristics are the useful measures to reveal in-formation processing and transfer features associated with Parkinson’s disease (PD) in basal ganglia. Most of state-of-the-art approaches compute such parameters continuous discrete forms strongly dependent on SUA recording length, noise level input parameters. Due specificity data collection (mainly short recordings relatively low signal-to-noise ratio) new techniques...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a standard treatment for advanced Parkinson's disease (PD). The precise positioning electrode can significantly influence results DBS and overall improvement in quality life PD patients receiving this therapy. We hypothesize that single unit activity (SUA) features serve as valid marker optimal DBS-electrode insertion trajectory, leading to most favorable outcome STN-DBS surgery. analyzed spontaneous SUA data recorded during...
Movement disorders such as Parkinson's disease (PD) and cervical dystonia (CD) are associated with abnormal neuronal activity in the globus pallidus internus (GPi). Reduced firing rate presence of spiking bursts typical for CD, while PD is characterized by high frequency tonic activity. This research aims to identify most important pallidal parameters classify these conditions. We analyzed single unit external (GPe) internal (GPi) segments 11 CD 10 patients who underwent standard DBS...
Nonlinear single unit activity (SUA) characteristics are the useful measures to reveal information processing and transfer features associated with Parkinson&rsquo;s disease (PD) in basal ganglia. Most of state-of-the-art approaches compute such parameters continuous discrete forms strongly dependent on SUA recording length, noise level input parameters. Due specificity data collection (mainly short recordings relatively low signal-to-noise ratio) new techniques evaluate neuronal...
Abstract Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a standard treatment for advanced Parkinson's disease (PD). The precise positioning electrode can significantly influence results DBS and overall improvement in quality life PD patients receiving this therapy. We hypothesize that single unit activity (SUA) features serve as valid marker optimal DBS‐electrode insertion trajectory, leading to most favorable outcome STN‐DBS surgery. analyzed spontaneous SUA data recorded...
One of the most successful and promising treatments for Parkinson’s disease today is deep brain stimulation (DBS). Accurate localization area critical outcome surgical DBS electrode implantation in subthalamic nucleus (STN). To achieve this, microelectrode recording used during surgery to precisely locate STN borders [1], while test stimulations with a macroelectrode are widely employed enhance placement accuracy. Thus, through testing multiple trajectories, clinically effective one can be...