A5001742229- Stress Responses and Cortisol
- Nerve injury and regeneration
- Neuroendocrine regulation and behavior
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Circadian rhythm and melatonin
- Peripheral Nerve Disorders
- Nerve Injury and Rehabilitation
- Antioxidant Activity and Oxidative Stress
- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Signaling Pathways in Disease
- Birth, Development, and Health
- Axon Guidance and Neuronal Signaling
- Viral gastroenteritis research and epidemiology
- Cell death mechanisms and regulation
- Nutrition, Genetics, and Disease
- Virus-based gene therapy research
- Memory and Neural Mechanisms
- Muscle Physiology and Disorders
- Protease and Inhibitor Mechanisms
Cincinnati Children's Hospital Medical Center
2012-2017
University of Cincinnati
2017
University of Cincinnati Medical Center
2012-2015
Vanderbilt University
2010
University of Kansas Medical Center
2007
To maintain well-being, all organisms require the ability to re-establish homeostasis in presence of adverse physiological or psychological experiences. The regulation hypothalamic-pituitary adrenal (HPA) axis during stress is important preventing maladaptive responses that may increase susceptibility affective disorders. Corticotropin-releasing hormone (CRH) a central HPA pathway and has been implicated stress-induced psychiatric disorders, reproductive cardiac function, as well energy...
The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components amygdalar circuits, which control appropriate fear responses. Despite this, molecular processes guiding ITC development remain poorly understood. Here we establish zinc finger transcription factor Tshz1 as a marker ITCs during their migration from dorsal lateral ganglionic eminence through maturity. Using germline and conditional knock-out (cKO) mouse models, show that is required for proper...
Early-life stress (ELS) leads to sustained changes in gene expression and behavior, increasing the likelihood of developing a psychiatric disorder adulthood. The neurobiological basis for later-in-life psychopathology is relatively unknown. current study used mouse model ELS, achieved by daily maternal separations during first 2 weeks postnatal life, test role amygdalar glucocorticoid receptor (GR) function mediating persistent increase risk-taking behaviors. ELS produced decrease GR mRNA...
Abstract The extracellular matrix surrounding the neuromuscular junction is a highly specialized and dynamic structure. Matrix metalloproteinases are enzymes that sculpt matrix. Since synaptic activity critical to structure function of this synapse, we investigated whether changes in levels could alter Metalloproteinases at junction. In particular, focused on Metalloproteinase 3 (MMP3), since antibodies MMP3 recognize molecules frog junction, cleaves number basal lamina molecules, including...
Glucocorticoid receptors (GR) in the paraventricular nucleus of hypothalamus (PVN) are important regulators negative feedback regulation hypothalamic-pituitary-adrenal (HPA) axis. Previous evaluation endogenous PVN GR function adult mice demonstrated that with loss exon 3 (Sim1Cre-GRe3Δ) have a hyperactive HPA axis, growth impairment and metabolic disruptions. Here, we hypothesized lack inhibition axis through GR, as early life, will developmental-stage-specific consequences....