A5030743285- CRISPR and Genetic Engineering
- Plant and animal studies
- Insect and Pesticide Research
- Insect and Arachnid Ecology and Behavior
- Insect symbiosis and bacterial influences
- Evolution and Genetic Dynamics
- Insect behavior and control techniques
- Animal Genetics and Reproduction
- Insect Resistance and Genetics
Wageningen University & Research
2020-2024
University of Edinburgh
2020-2023
Roslin Institute
2020-2023
Abstract Invasive species are among the major driving forces behind biodiversity loss. Gene drive technology may offer a humane, efficient and cost-effective method of control. For safe effective deployment it is vital that gene both self-limiting can overcome evolutionary resistance. We present HD-ClvR in this modelling study, novel combination CRISPR-based drives eliminates resistance localises spread. As case we model grey squirrel ( Sciurus carolinensis ), which an invasive pest UK...
Gene drive technology has the potential to address major biological challenges. Well-studied homing suppression drives have been shown be highly efficient in Anopheles mosquitoes, but for other organisms, lower rates of conversion prevent elimination target population. To tackle this issue, we propose a gene design that two targets: site where takes place, and distant cleavage induces population suppression. We model find two-target system allows occur over much wider range efficiency....
Abstract Social insects are very successful invasive species, and the continued increase of global trade transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its range in Western Europe. As an apex insect predator, hornet poses a serious threat to honey bee industry endemic pollinators. Current suppression methods have proven too inefficient expensive limit spread. Gene drives might be effective...
Varroa mites (Varroa destructor) are the most significant threat to beekeeping worldwide. They directly or indirectly responsible for millions of colony losses each year. Beekeepers somewhat able control varroa populations through use physical and chemical treatments. However, these methods range in effectiveness, can harm honey bees, be physically demanding on beekeeper, do not always provide complete protection from varroa. More importantly, some have developed resistance available...
Abstract Gene drive technology has the potential to address major biological challenges, including management of disease vectors, invasive species, and agricultural pests. After releasing individuals carrying gene in target population, suppression drives are designed spread at a rapid rate carry recessive fitness cost, thus bringing about decline population size or even complete suppression. Well-studied homing have been shown be highly efficient Anopheles mosquitoes were successful...
Abstract Invasive species are among the major driving forces behind biodiversity loss. Gene drive technology may offer a humane, efficient and cost-effective method of control. For safe effective deployment it is vital that gene both self-limiting can overcome evolutionary resistance. We present HD-ClvR, novel combination CRISPR-based drives eliminates resistance localises spread. As case study, we model HD-ClvR in grey squirrel ( Sciurus carolinensis ), which an invasive pest UK responsible...
Varroa mites ( destructor ) are the most significant threat to beekeeping worldwide. They directly or indirectly responsible for millions of colony losses each year. Beekeepers somewhat able control populations through use physical and chemical treatments. However, these methods range in effectiveness, can harm honey bees, be physically demanding on beekeeper, do not always provide complete protection from Varroa. More importantly, some have developed resistance available acaricides....
Social insects are very successful invasive species, and the continued increase of global trade transportation has exacerbated this problem. The yellow-legged hornet, Vespa velutina nigrithorax (henceforth Asian hornet), is drastically expanding its range in Western Europe. As an apex insect predator, hornet poses a serious threat to honey bee industry endemic pollinators. Current suppression methods have proven too inefficient expensive limit spread. Gene drives might be effective tool...