A5016787174- Appendicitis Diagnosis and Management
- Intestinal and Peritoneal Adhesions
- Omental and Epiploic Conditions
- Abdominal Surgery and Complications
- Opioid Use Disorder Treatment
- Sepsis Diagnosis and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Gallbladder and Bile Duct Disorders
- Poisoning and overdose treatments
- Immune Response and Inflammation
- Surgical Simulation and Training
- Analytical Chemistry and Chromatography
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal disorders and treatments
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Healthcare cost, quality, practices
- COVID-19 and healthcare impacts
- Diabetic Foot Ulcer Assessment and Management
- Gastrointestinal Tumor Research and Treatment
- Cardiac Arrest and Resuscitation
- Pleural and Pulmonary Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Advances in Oncology and Radiotherapy
- Zeolite Catalysis and Synthesis
United States Naval Hospital Okinawa
2020-2023
Naval Medical Center San Diego
2016-2022
Rady Children's Hospital-San Diego
2022
Harvey L. Neiman Health Policy Institute
2022
Sepsis is a major clinical challenge, with therapy limited to supportive interventions. Therefore, the search for novel remedial approaches of great importance. We addressed whether hyperbaric oxygen (HBOT) could improve outcome sepsis using an acute experimental mouse model. was induced in male CD-1 mice by cecal ligation and puncture (CLP) tailored result 80–90% mortality within 72 h insult. After CLP, were randomized into two groups receiving HBOT or not at different times after initial...
ABSTRACT Background The coronavirus disease 2019 (COVID-19) pandemic has had major clinical impact across the globe. Delayed presentation for medical emergencies been noted by community. There limited reporting on care emergent surgical conditions. We sought to describe effect of global and outcomes most common urgent general surgery process, acute appendicitis. Methods performed a retrospective review patients admitted United States Naval Hospital Okinawa during COVID-19 pandemic, from...
ABSTRACT Sepsis remains a major health problem at the levels of mortality, morbidity, and economic burden to care system, condition that is aggravated by development secondary conditions such as septic shock multiple-organ failure. Our current understanding etiology human sepsis has advanced, least in part, due use experimental animal models, particularly model cecum ligation puncture (CLP). Antibiotic treatment been commonly used this closely mirror patients. However, whether their may...
The omentum is a large mesenchymal fibro-fatty tissue with remarkable healing capability. It also rich in immune cells, including macrophages and lymphocytes, within particular structures named milky spots. Clinical observations indicate high incidence of peritonitis after the removal suggesting that it may play role sepsis. To test this possibility, male CD-1 mice underwent simultaneous omentectomy cecal ligation puncture (CLP), omentectomy-sham operation CLP alone, mortality was documented...
We describe the rare instance of concomitant biliary atresia and alpha-1-antitrypsin deficiency first documented successful portoenterostomy in this scenario. The potential for dual pathology must be recognized underscores that prompt diagnosis atresia, despite deficiency, is essential to afford longstanding native liver function.
Abstract Appendicoliths are commonly found obstructing the lumen of appendix at time appendectomy. To identify factors that might contribute to their formation we investigated composition appendicoliths using laser ablation inductively coupled plasma mass spectroscopy, gas chromatography, polarized light microscopy, X-ray crystallography and protein spectroscopy. Forty-eight elements, 32 fatty acids 109 human proteins were identified within appendicoliths. The most common elements in calcium...
Abstract Appendicoliths are commonly found obstructing the lumen of appendix at time appendectomy. To identify factors that might contribute to their formation we investigated composition appendicoliths using laser ablation inductively coupled plasma mass spectroscopy, gas chromatography, polarized light microscopy, X-ray crystallography, and protein spectroscopy. Forty-eight elements, 32 fatty acids, 109 human proteins were identified within appendicoliths. The most common elements in...