A5077439318- Heat shock proteins research
- Protein Structure and Dynamics
- Muscle Physiology and Disorders
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Extracellular vesicles in disease
- Caveolin-1 and cellular processes
- Immune Response and Inflammation
- COVID-19 and Mental Health
- Genetic Neurodegenerative Diseases
- Microtubule and mitosis dynamics
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Diabetic Foot Ulcer Assessment and Management
- T-cell and B-cell Immunology
- Genetic and Kidney Cyst Diseases
- Cardiac Fibrosis and Remodeling
- Cardiomyopathy and Myosin Studies
- Regulation of Appetite and Obesity
- Pain Mechanisms and Treatments
- Sepsis Diagnosis and Treatment
- Erythrocyte Function and Pathophysiology
- Nuclear Structure and Function
University of California, San Diego
2010-2024
Jacobs (United States)
2023
VA San Diego Healthcare System
2019
Heat shock proteins (hsp) are well recognized for their protein folding activity. Additionally, hsp expression is enhanced during stress conditions to preserve cellular homeostasis. Hsp also detected outside cells, released by an active mechanism independent of cell death. Extracellular appear act as signaling molecules part a systemic response stress. do not contain consensus signal secretion via the classical ER-Golgi compartment. Therefore, they likely exported alternative requiring...
Sepsis is a major clinical challenge, with therapy limited to supportive interventions. Therefore, the search for novel remedial approaches of great importance. We addressed whether hyperbaric oxygen (HBOT) could improve outcome sepsis using an acute experimental mouse model. was induced in male CD-1 mice by cecal ligation and puncture (CLP) tailored result 80–90% mortality within 72 h insult. After CLP, were randomized into two groups receiving HBOT or not at different times after initial...
Abstract Humans and chimpanzees are more sensitive to endotoxin than mice or monkeys, but any underlying differences in inflammatory physiology have not been fully described understood. We studied innate immune responses Cmah−/− mice, emulating human loss of the gene encoding production Neu5Gc, a major cell surface sialic acid. CMP–N-acetylneuraminic acid hydroxylase (CMAH) occurred ∼2–3 million years ago, after common ancestor humans chimpanzees, perhaps contributing speciation genus Homo....
Compared to other primates, humans are exceptional long-distance runners, a feature that emerged in genus Homo approximately 2 Ma and is classically attributed anatomical physiological adaptations such as an enlarged gluteus maximus improved heat dissipation. However, no underlying genetic changes have currently been defined. Two three million years ago, exon deletion the CMP-Neu5Ac hydroxylase ( CMAH ) gene also became fixed our ancestral lineage. Cmah loss mice exacerbates disease severity...
The expression of N-glycolylneuraminic acid (Neu5Gc) and the cytotoxic T cell (CT) carbohydrate can impact severity muscular dystrophy arising from loss dystrophin in mdx mice. Here, we describe these two glycans skeletal muscles dogs humans with or without dystrophin-deficiency. Neu5Gc was highly reduced (>95%) muscle normal golden retriever crosses (GR, n = 3) (GRMD, 5) at multiple ages (3, 6 13 months) when compared to mouse muscle, however, overall sialic GR GRMD remained high all ages....
Caveolin-1 (Cav-1) is an integral membrane protein that plays important role in proliferative and terminally differentiated cells. As a structural component of Caveolae, Cav-1 interacts with signaling molecules via caveolin scaffolding domain (CSD) regulating cell signaling. Recent reports have shown negative regulator tumor metastasis. Therefore, we hypothesize inhibits migration through its CSD. HeLa cells were engineered to overexpress (Cav-1 OE), without functional CSD (∆CSD), or...
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. Management of the relied mainly on SARS-CoV-2 vaccines, while alternative approaches such as meditation, shown to improve immunity, have been largely unexplored. Here, we probe relationship between meditation disease directly test impact induction a blood environment that modulates viral infection. We found inverse correlation length practice infection well accelerated resolution symptomology those infected....
Heat shock proteins (hsp) are well recognized for their protein folding activity. Additionally, hsp expression is enhanced during stress conditions to preserve cellular homeostasis. Hsp also detected outside cells, released by an active mechanism independent of cell death. Extracellular appear act as signaling molecules part a systemic response stress. do not contain consensus signal secretion via the classical ER‐Golgi compartment. Therefore, they likely exported alternative requiring...
Compared to other primates, humans are exceptional long‐distance runners, a characteristic that emerged in genus Homo ~2 million years ago (mya), and is generally attributed anatomical physiological adaptations such as striding bipedalism improved heat dissipation. Deletion of critical exon the CMAH gene also became fixed 2–3 mya our ancestral lineage––eliminating enzymatic activity, which generates major cell surface sialic acid Neu5Gc, by adding one oxygen atom Neu5Ac precursor. Modeling...
In‐depth knowledge of individual patients' physiology impacts perioperative management, which also efficacy and safety surgical procedures. Exosomes are a new paradigm in cellular communication, cell stress, biomarker development that have only recently begun to be addressed the population. Exosomes, secreted by almost all cells, carry biologically active molecules including DNA, RNA, proteins, lipids, cytokines, growth factors metabolites. The role exosomes population is not well known may...
Caveolin‐1 is the integral membrane protein that plays an important role in structure and function of terminally differentiated cells. As a structural component caveolae, caveolin scaffolding domain (CSD) has been associated with many cellular signaling processes recent reports have implicated Cav‐1 as negative regulator tumor metastasis. We hypothesized may be inhibiting cell migration through its CSD. To assess this, HCT‐116 cells (which contain high endogenous Cav1) HT‐29 low were...