A5051356666- Lipid Membrane Structure and Behavior
- Pharmacological Effects of Natural Compounds
- Free Radicals and Antioxidants
- Analytical Chemistry and Chromatography
- Neurological Disorders and Treatments
- Food Chemistry and Fat Analysis
- Surfactants and Colloidal Systems
- Chemical synthesis and alkaloids
- Natural product bioactivities and synthesis
- Microencapsulation and Drying Processes
- Proteins in Food Systems
- Medicinal plant effects and applications
- Nanoparticle-Based Drug Delivery
- Silicon Nanostructures and Photoluminescence
- Scientific Research and Studies
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Adsorption, diffusion, and thermodynamic properties of materials
- Magnolia and Illicium research
- Alcoholism and Thiamine Deficiency
- Nanowire Synthesis and Applications
- Chemical synthesis and pharmacological studies
- Ginkgo biloba and Cashew Applications
- Food Industry and Aquatic Biology
Voronezh State University
2016-2023
Introduction. Microencapsulation is one of the promising areas for obtaining new dosage forms. The peculiarity microencapsulated forms that substance protected from effects various environmental factors can cause their destruction (acidity gastric juice, effect food, joint intake other drugs, diseases gastrointestinal tract, etc.). This method used groups such as antibiotics, nootropics, vitamins, probiotics, anticonvulsants, enzymes. Particular attention should be paid to antibacterial...
Currently the most prospective way in pharmacotherapy is obtaining of nanoparticles involving pharmaceutical substances. Application porous inorganic materials on basis silicon among main features solving this problem. The present work concerned with problem deposition drug nootropic activity – vinpocetine into silicon. Silicon were obtained by electrochemical anodic etching Si plates. process was studied dependence time. As a result investigations it found that infrared transmission spectra...
Микрокапсулы в настоящее время нашли применение различных отраслях.Микрокапсулы с витаминами, эфирными и жирными маслами входят состав косметических средств (кремов, гелей, сывороток).Микрокапсулированные пробиотики используются кормах кормовых добавках ветеринарии.Важная область применения микрокапсулирования фармации -совмещение общей дозировке лекарственных веществ, несовместимых при смешении свободном виде.Цель работы -сравнительный анализ термодинамических характеристик высвобождения...
Introduction. The scientific and practical interest in the problem of microencapsulation remains high, as evidenced by extensive literature on this subject. choice a film former carrier active substance is determined its required release rate latter, which depends largely physical properties latter. Biodegradable polymers, sodium alginate gelatin, are often used coating. aim research comparative analysis thermodynamic characteristics vinpocetine from microcapsules containing shell, into...
The aim of the investigation is to study morphological, technological and biopharmaceutical properties alginate-chitosan microcapsules with Vinpocetine. Materials Methods : Alginate-chitosan different concentrations sodium alginate (0.5%, 1%, 1.5%, 2%, 2.5% 3%) a medium viscosity chitosan solution (0.25-0,5%), as well not treated chitosan, were obtained. surface morphology was studied by methods atomic-powered microscopy use an NT-MDT Corporation probe scanning microscope (model Solver P47...
Computer modeling is currently a promising technique used in pharmaceutical technologies to develop drug compositions. Molecular dynamics has provided space and time resolutions unavailable during experiments thus greatly extended the capabilities of chemistry some other areas. stimulations are very important for development solid dispersions. The purpose this study simulate molecular release desloratadine from alloys containing polyvinylpyrrolidone-10000 into dissolution medium. was...
Дезлоратадин, лекарственный препарат с доказанной антигистаминной активностью, в настоящее время на фармацевтическом рынке представлен лекарственных формах: таблетки, раствор и сироп. Существенным фактором, ограничивающим разработку новых средств дезлоратадина, является его низкая растворимость воде. Весьма актуальным направлением фармацевтической технологии связи этим являются исследования по созданию форм направленные повышение растворимости воде, том числе основе твердых дисперсий. В...
In the experimental investigations using dispersion technique microcapsulated drug formulation of vinpocetine was obtained in a system «liquid-liquid». The process release substance from microcapsules studied vitro dependence on size formulation, composition shell and medium where were obtained. Optimal selected for elaborated formulation. Fused beeswax cocoa butter ratio 3:2 found to be most rational with purified water 2% solution Na-CM cellulose applied as medium. Keywords:...
Nowadays cardiovascular diseases are the main cause of death among population around word. The development new drugs, giving a possibility to normalize blood pressure, is promising direction in field pharmacy and medicine. Now inhibitors angiotensinconverting enzyme (ACE) widely adopted for treatment hypertension chronic heart failure. principle action ACE based on blocking conversion angiotensin I into II, which mediates vasodilation. aim work selection methods lisinopril interaction with...
Microencapsulation is a method of obtaining traditional materials in unique form that able to protect substances from the effects environmental factors cause their decomposition.This used medicine and pharmacy, where drugs enzymes are encapsulated biodegradable microcapsules.The aim study was possibility use sodium alginate for microencapsulation vinpocetine on basis comparative analysis thermodynamic characteristics concerned with efficiency release into water ethanol.The following methods...
An important task in technology of chemical-pharmaceutical preparations is the improvement drug formulations, development new alternative delivery methods for biologically active substances as well changes systems components.A search and implementation nano-size formulations related to nootropic series fact an actual medicine.Correct interpretation experimental data study reactant release from such nanoparticles impossible without comprehension physico-chemical processes occurring at...
In the present work investigations were performed concerned with determination of optimal ratio vinpocetine and polyethylene glycol within a solid dispersion (1:2 or 1:5) according to simulation results in framework molecular dynamics associated release reactant into aqueous medium. For from its alloy technique coarse-grained force field Martini 2.2 was applied use Gromacs 2018 computer program. Results demonstrated that at pH 6.8 facilitated solubilization thus considerably enhanced...
Introduction. Currently, there is a large number of antibacterial medications for the treatment infectious diseases on pharmaceutical market. Fluoroquinolones, being an important group among these medications, have wide spectrum action and are active against multiresistant bacteria, one which ofloxacin. Ofloxacin characterized by low solubility belongs to second class according biopharmaceutical classification so it advisable use method introducing into solid carriers increase...
Introduction. Liposomal preparations have a number of advantages: they protect the cells body from toxic effects drugs; prolong action drug introduced into body; medicinal substances degradation; contribute to manifestation targeted specificity due selective penetration blood tissues; change pharmacokinetics drugs, increasing their pharmacological efficacy; allow you create water-soluble form substances, thereby bioavailability. In this work, studies were carried out develop methodology for...
Introduction . Liposomal preparations have the following advantages: they protect body cells from toxic effects of drugs; prolong action drug introduced into body; medicinal substances degradation; promote manifestation targeted specificity due to selective penetration blood tissues; change pharmacokinetics drugs, increasing their pharmacological effectiveness; allow you create a water-soluble form number substances, thereby bioavailability. The development liposomal forms vinpocetine is...
Purpose of investigation: simulation vinpocetine release from sodium alginate with a chitosan shell into solvents. Data obtained in the computing experiment demonstrate that mean values Van-der-Waals energy interaction between and solvent acidic medium is less than neutral one ethanol. Moreover, only slight was observed unlike