A5042894759- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Noise Effects and Management
- Neural dynamics and brain function
- Neuroscience and Music Perception
- Speech and Audio Processing
- Hearing Impairment and Communication
- Tryptophan and brain disorders
- Multisensory perception and integration
- Advanced MRI Techniques and Applications
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Phonetics and Phonology Research
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Stress Responses and Cortisol
- Male Reproductive Health Studies
City University of Hong Kong
2018-2025
Miami University
2024
Institut Pasteur
2023
City University of Hong Kong, Shenzhen Research Institute
2021-2022
Spatial hearing in cochlear implant (CI) patients remains a major challenge, with many early deaf users reported to have no measurable sensitivity interaural time differences (ITDs). Deprivation of binaural experience during an critical period is often hypothesized be the cause this shortcoming. However, we show that neonatally deafened (ND) rats provided precisely synchronized CI stimulation adulthood can trained lateralize ITDs essentially normal behavioral thresholds near 50 μs....
Abstract Spatial hearing remains one of the major challenges for bilateral cochlear implant (biCI) users, and early deaf patients in particular are often completely insensitive to interaural time differences (ITDs) delivered through biCIs. One popular hypothesis is that this may be due a lack binaural experience. However, we have recently shown neonatally deafened rats fitted with biCIs adulthood quickly learn discriminate ITDs as well their normal litter mates, perform an order magnitude...
Although cochlear implants (CIs) provide valuable auditory information to more than one million profoundly deaf patients, these devices remain inadequate in conveying fine timing cues. Early patients particular struggle use interaural time differences (ITDs) for spatial hearing and scene analysis. Why CI experience limitations remains controversial. One possible explanation, which we investigate here, is that the stimulation by clinical CIs inappropriate, as it encodes temporal features of...
Bilateral cochlear implant (CI) patients face challenges in utilizing interaural time differences (ITDs). Our research on neonatally deafened (ND) CI rats revealed excellent ITD sensitivity even without early sensory input when CIs are synchronized. However, these exhibit abnormal temporal weighting functions (TWFs), showing reduced "onset dominance" to normal hearing (NH) subjects. This study explores the impact of experience with jittered binaural pulses perception ND rats. Neonatal rat...
Abstract Cochlear implants (CIs) have restored enough of a sense hearing to around one million severely impaired patients enable speech understanding in quiet. However, several aspects with CIs remain very poor. This includes limited ability CI make use interaural time difference (ITD) cues for spatial and noise reduction. A major cause this poor ITD sensitivity could be that current clinical devices fail deliver information manner is accessible the auditory pathway. processors measure...
Background/Objectives: Rodents provide a useful translational model of fear- and anxiety-related behaviors. Previously stressed animals exhibit physiological behavioral stress responses that parallel those observed in anxious humans. Patients diagnosed with post-traumatic disorder (PTSD) present spectrum debilitating anxiety symptoms result from exposure to one or more traumatic events, individuals exposed early adverse experiences women having increased vulnerability for diagnoses; however,...
Abstract Cochlear implants (CIs) can restore a high degree of functional hearing in deaf patients however spatial remains poor, with many early CI users reported to have no measurable sensitivity interaural time differences (ITDs) at all. Deprivation binaural experience during an critical period is often blamed for this shortcoming. However, we show that neonatally deafened rats provided precisely synchronized stimulation adulthood be trained localize ITDs essentially normal behavioral...
Introduction Cochlear implant (CI) patients show low sensitivity to interaural time differences (ITDs), which are important for spatial hearing. The lack of ITD in CI may be due technical limitations the CIs. In majority clinical processors, acoustic ITDs not encoded timing electrical stimulus pulses. Thus, only envelope (envITDs) provide reliable information. However, it is uncertain whether electrically stimulated auditory pathway can process envelopes with sufficient precision determine...
Einleitung Cochlea-Implantat (CI)-Patienten zeigen eine geringe Sensitivität für interaurale Laufzeitdifferenzen (ITDs), die wichtig Richtungshören sind. Grund fehlende ITD können technische Limitierungen, wie unzureichende binaurale Abstimmung der Stimulationspulse bei Mehrheit klinischer Prozessoren sein. Somit liefern nur Hüllkurven-ITDs (envITDs) zuverlässig verwertbare Informationen. Allerdings kann nicht mit Sicherheit angenommen werden, dass elektrisch stimulierte Hörbahn Hüllkurven...
Sound localization is one of the major challenges for bilateral cochlear implant (CI) users. Their ability to use binaural cues, especially interaural time differences (ITDs), falls below that normal hearing peers. Our recent study on neonatally deafened (ND), CI implanted rats has shown very good ITD sensitivity can be developed even in absence early sensory input if CIs are synchronized. Here, we investigate onset weighting between ND and (NH) across different pulse rates.
Schalllokalisation ist eine der größten Herausforderungen für Cochlea-Implantat (CI) Träger. Ein Grund die begrenzte Wahrnehmung binauraler Signale, insbesondere interauraler Zeitdifferenz (ITD). Unsere aktuelle Studie an neonatal ertaubten (ND), CI-versorgten Ratten hat gezeigt, dass auch ohne frühe Hörerfahrung sehr gute ITD Sensitivität entwickelt werden kann, wenn CIs synchronisiert sind. Wir untersuchen Gewichtung ITD-Sensitivität von und normal hörenden (NH) über verschiedene Pulsraten.
Abstract Background Spatial hearing remains one of the major challenges for bilateral cochlear implant (biCI) users, and early deaf patients in particular are often completely insensitive to interaural time differences (ITDs) delivered through biCIs. One popular hypothesis is that this may be due a lack binaural experience. However, we have recently shown neonatally deafened rats fitted with biCIs adulthood quickly learn discriminate ITDs as well their normal litter mates, perform an order...
Frühertaubte Cochlea-Implantat (CI) Patienten zeigen eine geringe Sensitivität für interaurale Laufzeitunterschiede (ITDs), welche wichtig ist Richtungshören und Sprachverständnis. Heutige CI Prozessoren weisen keine bilaterale Synchronisation auf, was bei elektrischer Stimulation des auditorischen Systems durch einen Zeitversatz zwischen den beiden zu inkonsistenter uninformativer ITD Präsentation führt. Wir untersuchen, ob unter asynchroner die Entwicklung von im hörunerfahrenen System...
Early deafened cochlear implanted (CI) patients exhibit poor sensitivity for interaural time differences (ITD), which play a major role in sound localisation and speech understanding. Current CI processors lack bilateral synchronisation. This results inconsistent uninformative ITD presentation when stimulating the auditory system electrically due to an offset between two clock times. Here, we investigate whether development of is impaired hearing inexperienced subjected asynchronous stimulation.