A5086650674- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Vascular Procedures and Complications
- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Connective tissue disorders research
- Peripheral Artery Disease Management
- Vasculitis and related conditions
- Wine Industry and Tourism
- Cardiac tumors and thrombi
- Eicosanoids and Hypertension Pharmacology
- Entomological Studies and Ecology
- Renal and Vascular Pathologies
- Hormonal Regulation and Hypertension
- Inflammatory mediators and NSAID effects
- Central Venous Catheters and Hemodialysis
- Abdominal vascular conditions and treatments
- Muscle and Compartmental Disorders
- Orthopaedic implants and arthroplasty
- Cardiac Valve Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Nutrition and Health Studies
Hospital de Sant Pau
2012-2024
Institut de Recerca Sant Pau
2023-2024
Centro de Investigación Biomédica en Red
2021-2024
Universitat Autònoma de Barcelona
2002-2023
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2023
Institut d'Investigacions Biomèdiques de Barcelona
2013-2023
Universitat de Barcelona
2020
Instituto de Cardiología y Cirugía Cardiovascular
2002
ABSTRACT Clinical management of abdominal aortic aneurysm (AAA) is currently limited to elective surgical repair because an effective pharmacotherapy still awaited. Inhibition histone deacetylase (HDAC) activity could be a promising therapeutic option in cardiovascular diseases. We aimed characterise HDAC expression human AAA and evaluate the potential class I IIa inhibitors model angiotensin II (Ang II)-infused apolipoprotein-E-deficient (ApoE−/−) mice. Real-time PCR, western blot...
We investigated the prostaglandin (PG)E2 pathway in human abdominal aortic aneurysm (AAA) and its relationship with hypervascularization. analyzed samples from patients undergoing AAA repair comparison those healthy multiorgan donors. Patients were stratified according to maximum diameter: low diameter (LD) (<55 mm), moderate (MD) (55-69.9 high (HD) (≥70 mm). was characterized by abundant microvessels media adventitia perivascular infiltration of CD45-positive cells. Like endothelial cell...
Summary Abdominal aortic aneurysm (AAA) is a common disease with significant heritability. In this study, we performed genome-wide association meta-analysis from 14 discovery cohorts and uncovered 144 independent associations, including 97 previously unreported loci. A polygenic risk score derived was able to explain AAA beyond clinical factors. Genes at loci indicate involvement of lipid metabolism, vascular development remodeling, extracellular matrix dysregulation inflammation as key...
Advanced biomechanical models can provide additional information concerning rupture risk in abdominal aortic aneurysms (AAA). Here we evaluated the predictive value of finite element analysis (FEA) to assess AAA risk.In a case-control study, compared FEA parameters group symptomatic (sAAA) patients, considered as high group, with asymptomatic patients (aAAA).We included 15 sAAA and 28 aAAA matched for age- maximum diameter diagnosed infrarenal non-ruptured at our center between 2009 2013....
A variety of disorders are known to be related with aortic geometry, among them abdominal aneurysm (AAA). This work aims present the main determinants diameter in a new cohort families at high risk AAA. The Triple-A Genomic Analysis (TAGA) study comprises 407 individuals 12 families. Each family was collected through proband We calculated heritability and genetic correlations between clinical parameters. genome-wide linkage scan performed based on 4.6 million variants. predictive model...
ABSTRACT Background Abdominal aortic aneurysms (AAA) are focal dilatations of the abdominal aorta. They normally asymptomatic and progressively expand, increasing their risk rupture. Rupture an AAA is associated with high mortality rates, but mechanisms underlying initiation, expansion rupture not yet fully understood. This study aims to characterize identify new genes pathophysiology through differential expression analyses between dilated non-dilated tissue samples, different diameters....
Background Abdominal aortic aneurysms (AAAs) are focal dilatations of the abdominal aorta that expand progressively, increasing their risk rupture. Rupture an AAA is associated with high mortality rates, but mechanisms underlying initiation, expansion, and rupture AAAs not yet fully understood. We aimed to characterize pathophysiology identify new genes initiation progression. Methods Results This study used RNA sequencing data on 140 samples, becoming largest set for differential expression...
BACKGROUND: Due to population aging and the spread of endovascular techniques for aortic diseases, there has been an increase in older intervened. Objectively assessing patient’s global status becomes mandatory advanced ages, as impaired functional frailty are associated with higher postoperative mortality rates. The aim this paper is evaluate impact a systematic geriatric preoperative assessment on outcomes interventions.METHODS: All patients above 60 years old surgical indication disease...
Introduction: Iliac artery endofibrosis (IAE) is an uncommon disease, poorly studied pathology with devastating effects and different therapeutic approaches affecting young people who practise intensive sports, especially cyclists.The evolution of the process not only depends on diagnosis action, but also acceptance attitude patient subsequent professional guidance.Case description: This case description a triathlon athlete that had one previous iliac surgical revascularization for IAE was...
We present the case of a patient with chronic type B aortic dissection previous iliac to visceral debranching graft and thoracoabdominal endograft who, because Ib endoleak diameter enlargement, required complex solution involving placement thoracic endovascular inside Dacron 180° curved shape in three-stage surgery. At 9 months follow-up, he had no evidence I endoleaks, decreased.
Background: The risk of Abdominal Aortic Aneurysms (AAA) rupture is associated with aneurysm size and growth rate. There substantial variation in rates between individuals. present study aims to provide a global description per intervals AAA diameter for individuals the Spanish population, understand possible causes rate variability, assess practitioners on safe follow-up visits patients.
Background: Abdominal aortic aneurysms (AAA) are focal dilatations of the abdominal aorta. They normally asymptomatic and expand progressively, increasing their risk rupture. Rupture an AAA is associated with high mortality rates, but mechanisms underlying initiation, expansion rupture not yet fully understood. This study aims to characterize pathophysiology identify new genes initiation expansion.
<h3>Background</h3> Giant cell arteritis (GCA) typically affects cranial vessels, but it can also affect large vessels in a high percentage of patients. Vascular inflammation the aorta and/or its main branches cause complications morbidity and mortality such as aneurysms, dissection, thrombosis require aortic surgery. The analysis different clinical imaging patterns patients with GCA aortitis their relationship prognosis needs more investigation. Early identification highest risk could help...