A5037469025- Monoclonal and Polyclonal Antibodies Research
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
- Biochemical and Molecular Research
- Corneal Surgery and Treatments
- Amino Acid Enzymes and Metabolism
- Ocular Surface and Contact Lens
- Ubiquitin and proteasome pathways
- Neuropeptides and Animal Physiology
- Advanced Drug Delivery Systems
- Alcoholism and Thiamine Deficiency
- Computational Drug Discovery Methods
- Biochemical Acid Research Studies
- Neuroscience and Neuropharmacology Research
- Histone Deacetylase Inhibitors Research
- Receptor Mechanisms and Signaling
Italian Institute of Technology
2019-2025
National Enterprise for NanoScience and NanoTechnology
2021-2025
National Research Council
2023
Scuola Normale Superiore
2021
University of Pisa
2016
Intranasal drug delivery is convenient and provides a high bioavailability but requires the use of mucoadhesive nanocarriers. Chitosan well-established polymer for applications can suffer from poor cytocompatibility stability upon administration. In this work, we present method to obtain stable cytocompatible crosslinked chitosan nanoparticles. We used 2,6-pyridinedicarboxylic acid as biocompatible crosslinker compared obtained particles with those prepared by ionotropic gelation using...
The trace amine-associated receptor 1 (TAAR1) is a G-protein-coupled receptors (GPCR) potently activated by variety of molecules besides amines (TAs), including thyroid hormone-derivatives like 3-iodothyronamine (T1AM), catechol-O-methyltransferase products 3-methoxytyramine, and amphetamine-related compounds. Accordingly, TAAR1 considered promising target for medicinal development. To gain more insights into physiological functions validation its therapeutic potential, we recently developed...
Open AccessExtended Abstract Novel Dual PDK1/AurK-A Inhibitors for Cancer Therapy: Med Chem Evolution and Crystallographic Investigation † by Simona Sestito 1, Sara Chiarugi 2, Eleonora Margheritis Massimiliano Runfola Simone Bertini Gianpiero Garau 2 Rapposelli 1,* 1 Department of Pharmacy, University Pisa, 56126 Italy BioStructures Lab, [email protected]—Istituto Italiano di Tecnologia, * Author to whom correspondence should be addressed. Presented at the 2nd Molecules Medicinal Chemistry...