A5109568959- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Health, Environment, Cognitive Aging
- Risk Perception and Management
- Chemical Safety and Risk Management
- Nitric Oxide and Endothelin Effects
- Blood disorders and treatments
- Pesticide Exposure and Toxicity
- Kawasaki Disease and Coronary Complications
- Vasculitis and related conditions
- Neuroscience and Neuropharmacology Research
- Global Public Health Policies and Epidemiology
- Coccidia and coccidiosis research
- Dye analysis and toxicity
- Cell death mechanisms and regulation
- Folate and B Vitamins Research
- Biomedical Text Mining and Ontologies
- Mycotoxins in Agriculture and Food
- Sulfur Compounds in Biology
- Radioactivity and Radon Measurements
- Coronary Artery Anomalies
Environmental Protection Agency
2007-2024
National Center for Environmental Assessment (EPA)
2019-2023
United States Department of Health and Human Services
2022
Research Triangle Park Foundation
2020
National Institutes of Health
2004-2006
National Institute of Infectious Diseases
2003-2005
AdventHealth Orlando
2003-2004
University of South Florida
2003
Naphthalene is a polycyclic aromatic hydrocarbon that has been associated with health effects, including cancer. As the state of science on naphthalene toxicity continues to evolve, updated reference value(s) may be required support human risk assessment.We present systematic evidence map studies could used derive for naphthalene.Human and animal effect physiologically based pharmacokinetic (PBPK) models were identified from literature search populations, exposures, comparators, outcomes...
Systematic review tools that provide guidance on evaluating epidemiology studies are receiving increasing attention and support because their application facilitates improved quality of the review, consistency across reviewers, transparency for readers. The U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) Program has developed an approach systematic evidence health effects from chemical exposures includes structured approaches literature search screening,...
Abstract We have established an animal model of coronary arteritis which is histopathologically similar to that observed in cases Kawasaki disease (KD), a well‐known childhood vasculitis syndrome. Coronary this mouse has been induced by intraperitoneal injection Candida albicans ‐derived substances (CADS). Arteritis varied strain with the highest incidence 71.1% (27/38) found C3H/HeN mice, but absent CBA/JN mice (0%, 0/27), suggesting association genomic background develop disease. The...
Septin 3 is a novel member of the septin subfamily GTPase domain proteins that was recently identified in human neuronal cells. These are involved vesicle trafficking, neurite outgrowth, and neurofibrillary tangle formation; however, expression functional role normal tissues as an etiological agent neurological disorders currently unclear. To further characterize these parameters, present study analyzed three isoforms (A, B, C) fetal adult brains polymorphism exon 11 microsatellite control,...
Systematic evidence maps (SEMs) are increasingly used to inform decision-making and risk management priority-setting serve as problem formulation tools refine the focus of questions that get addressed in full systematic reviews. Within U.S. Environmental Protection Agency (EPA) Office Research Development (ORD) Integrated Risk Information System (IRIS), SEMs have been data gaps, determine need for updated assessments, assessment priorities, development study evaluation considerations, among...
Poly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30), also termed as poly(ADP-ribose) synthetase, is a key enzyme in the recognition and repair of damaged DNA. Several conditions (e.g., ischemia-reperfusion or chemical-induced injury) have been shown to overactivate PARP-1, causing neurodegeneration necrotic apoptotic cell death from NAD+ ATP depletion. In contrast, inhibitors PARP-1 neuroprotective effect by ameliorating this response. The purpose study was determine effects three routinely...
BackgroundEnvironmental health and other researchers can benefit from automated or semi-automated summaries of data within published studies as summarizing study methods results is time resource intensive. Automated be designed to identify extract details interest pertaining the design, population, testing agent/intervention, outcome (etc.). Much reported across existing publications lack unified structure, standardization machine-readable formats may presented in complex tables which serve...
Animal models suggest that a deficiency in myeloperoxidase (MPO; EC 1.11.1.7), lysosomal hemoprotein involved host defense, may be associated with decreased level of immunity. A nonsynonymous mutation, resulting an arginine to cysteine substitution (Arg499Cys or R499C), has been identified the exon 9 genetic coding region Japanese patient complete MPO deficiency. Genetic analysis revealed mRNA could correctly transcribed then further translated into peptide sequence. However, Western blot...
Adult male ICR mice were treated by intraperitoneal injection with 250 mg/kg of bodyweight commercial malathion (a dose corresponding to 1/12 the LD50). After 6 h, acetylcholinesterase (AChE) activity in blood, liver, and six brain regions was determined. A statistically significant inhibition observed whole blood (23%), liver (21%), and, particular, central nervous system; greatest degree AChE cerebellum (45%), followed hippocampus (29%). There no change caudate putamen, frontal cortex,...
Myeloperoxidase (MPO; EC 1.11.1.7) is a lysosomal hemeprotein that plays an important role in the host defense mechanism against microbial diseases. This neutrophil disorder, characterized by lack of MPO, may result weakened activity. Complete MPO deficiency has been postulated to be originate from genomic mutation. Recently, two Japanese patients were reported with deficiency. Both had base substitutions exon 9 region gene; close proximity functionally residue, His502. Genomic DNA 387...
Systematic review (SR) methods are relied upon to develop transparent, unbiased, and standardized human health chemical assessments. The expectation is that these assessments will have discovered evaluated all of the available information in a trackable, reproducible manner inherent SR principles. challenge assessment development relies on mostly literature-based data using manual approaches not scalable. Various tools increased efficiency by implementing semi-automated (human loop) for...
ISEE-184 Objective: The Integrated Risk Information System (IRIS) is a public use electronic database (www.epa.gov/iris) developed by the US Environmental Protection Agency. It currently receives more than 250,000 Web-page hits per month from and private sector users in over 100 countries. This searchable of 545 chemicals includes qualitative quantitative health effects information pertaining to hazard identification dose-response components risk assessment process. Our objective was...
with data on MS genetic epidemiology in other populations [7], and (4) the same set can serve as basis for molecular studies aimed at correlating clinical phenotypes to etiological polymorphisms.
Introduction: Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants found in the environment. Endometriosis, an estrogen-dependent gynecological disease, affects about 15% women reproductive age. Previous studies have suggested associations between PCB levels and occurrence endometriosis. Aim: To systematically evaluate available epidemiologic literature investigating potential exposure Methods: We did title abstract search searched for containing using specific...