A5078637418- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Fatty Acid Research and Health
- Ocular Surface and Contact Lens
- Proteoglycans and glycosaminoglycans research
- advanced mathematical theories
- Glaucoma and retinal disorders
- Cancer, Hypoxia, and Metabolism
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- NF-κB Signaling Pathways
- Analytical Chemistry and Chromatography
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Adenosine and Purinergic Signaling
- Seaweed-derived Bioactive Compounds
- Advanced Glycation End Products research
- Stress Responses and Cortisol
- Crystallization and Solubility Studies
- Mathematical Dynamics and Fractals
- Metabolism and Genetic Disorders
Lomonosov Moscow State University
2016-2025
Peoples' Friendship University of Russia
2019-2025
St Petersburg University
2024
Moscow State University
2012-2023
Rusal (Russia)
2022
Pirogov Russian National Research Medical University
2017-2018
Otto-von-Guericke University Magdeburg
2014-2015
Russian State Hydrometeorological University
2010
Kazan Federal University
1996
Hyaluronic acid (HA), a major glycosaminoglycan of the extracellular matrix, has cell signaling functions that are dependent on its molecular weight. Anti-inflammatory effects for high-molecular-weight (HMW) HA and pro-inflammatory low-molecular-weight (LMW) were found various myeloid cells, including microglia. Astrocytes cells ectodermal origin play pivotal role in brain inflammation, but link between with different weights an inflammatory response these is not clear. We tested LMW HMW rat...
Peroxisome proliferator-activated receptors (PPAR)-α and -γ in astrocytes play important roles inflammatory brain pathologies. Understanding the regulation of both activity expression levels PPARs is an neuroscience issue. Toll-like receptor (TLR) agonists are stimuli that could modulate PPAR, but mechanisms their control poorly understood. In present study, we report lipopolysaccharide, peptidoglycan, flagellin, which TLR4, TLR1/2, TLR5, respectively, exert time- nuclear factor...
Although many neurological and psychiatric disorders reveal clear sex-dependent variations, the molecular mechanism of this process is not enough. Astrocytes are involved in response neural tissue to injury inflammation, produce steroid hormones, sense presence. To explore hypothesis that astrocytes may participate sex-mediated differences inflammatory responses, we have examined whether male female primary rat show different responses lipopolysaccharide (LPS) as a toll-like receptor 4...
The involvement of oxylipins, metabolites polyunsaturated fatty acids, in cancer pathogenesis was known long ago, but only the development high-throughput methods get opportunity to study oxylipins on a system level. aimed elucidate alterations oxylipin metabolism as characteristics breast patients. We compared ultra-high-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) profile signatures blood plasma 152 healthy volunteers (HC) and 169 patients with different stages (BC). To...
Ocular inflammation contributes to the pathogenesis of blind-causing retinal degenerative diseases, such as age-related macular degeneration (AMD) or photic maculopathy. Here, we report on inflammatory mechanisms that are associated with induced by bright visible light, which were revealed while using a rabbit model. Histologically and electrophysiologically noticeable retina is preceded accompanied oxidative stress inflammation, evidenced granulocyte infiltration edema in this tissue, well...
Inflammatory activation of astroglia adds to the pathology various neurological diseases. Astrocytes respond microglia-derived cytokines such as interleukin-1α (IL-1α) with enhanced inflammatory signaling. This provokes pro-inflammatory gene expression of, among others, eicosanoid-generating enzyme prostaglandin endoperoxide synthase 2 (Ptgs2). Whereas metabolic regulation innate immune cell responses is intensely studied, pathways related how metabolism modulates signaling in astrocytes are...
Neuroinflammation is a key process of many neurodegenerative diseases and other brain disturbances, astrocytes play an essential role in neuroinflammation. Therefore, the regulation astrocyte responses for inflammatory stimuli, using small molecules, potential therapeutic strategy. We investigated potency peroxisome proliferator-activated receptor (PPAR) ligands to modulate stimulating effect lipopolysaccharide (LPS) primary rat on (1) polyunsaturated fatty acid (PUFAs) derivative...
Primary open-angle glaucoma (POAG) is characterized by degeneration of retinal ganglion cells associated with an increase in intraocular pressure (IOP) due to hindered aqueous humor (AH) drainage through the trabecular meshwork and uveoscleral pathway. Polyunsaturated fatty acids oxylipins are signaling lipids regulating neuroinflammation, neuronal survival AH outflow. Among them, prostaglandins have been previously implicated employed for its treatment. This study addressed role determining...
Background: Astrocytes play a key role in the inflammatory process accompanying various neurological diseases. Extracellular ATP accompanies processes brain, but its effect on lipid mediators (oxylipins) astrocytes remains elusive. Metformin is hypoglycemic drug with an anti-inflammatory that has been actively investigated context of therapy for neuroinflammation, mechanisms action are not fully elucidated. Therefore, we aimed to characterize effects markers and oxylipin profiles; determine...
Abstract Peroxisome proliferator‐activated receptor β/δ (PPARβ/δ) is a potential regulator of neuroinflammation. Toll‐like receptors (TLR) are innate immunity‐related inflammatory stimuli. In the present report, we evaluate molecular mechanisms regulation mRNA , protein, and transcriptional activity levels PPARβ/δ by agonists TLR4, TLR1/2, TLR5, using lipopolysaccharide (LPS), peptidoglycan, flagellin, respectively. We found that these stimuli increase in astrocytes. Expression separately...
An antidiabetic drug of the thiazolidinedione class, rosiglitazone (RG) demonstrates anti-inflammatory properties in various brain pathologies. The mechanism RG action cells is not fully known. To unravel mechanisms modulation toll-like receptor (TLR) signaling pathways, we compare primary rat neuron and astrocyte cultures stimulated with TLR4 agonist lipopolysaccharide (LPS) TLR3 poly I:C (PIC). Both TLR agonists induced tumor necrosis factor (TNFα) release astrocytes, but neurons. Neurons...
Functional phenotypes, which cells can acquire depending on the microenvironment, are currently focus of investigations into new anti-inflammatory therapeutic approaches. Glial cells, microglia, and astrocytes major participants in neuroinflammation, but their roles differ, as microglia mesodermal origin, while ectodermal origin. The inflammatory phenotype be modulated by ω-6- ω-3-polyunsaturated fatty acid-derived oxylipins, although data changes oxylipin profiles different cell adaptations...
Dry eye syndrome (DES) is characterized by decreased tear production and stability, leading to desiccating stress, inflammation corneal damage. DES treatment may involve targeting the contributing inflammatory pathways mediated polyunsaturated fatty acids their derivatives, oxylipins. Here, using an animal model of general anesthesia-induced DES, we addressed these characterizing changes in lipidome, correlation with pathophysiological biochemical signs disease. The decline was associated...
Age‐related impairment of coordination the processes maintaining mitochondrial homeostasis is associated with a decrease in functionality cells and leads to degenerative processes. mtDNA can be marker oxidative stress tissue degeneration. However, mechanism accumulation age‐related damage remains unclear. In present study, we analyzed several organs rats during aging possibility reversing these alterations by dietary restriction (DR). We showed that brain compartments (with exception...
Primary open-angle glaucoma (POAG) is a frequent blindness-causing neurodegenerative disorder characterized by optic nerve and retinal ganglion cell damage most commonly due to chronic increase in intraocular pressure. The preservation of visual function patients critically depends on the timeliness detection treatment disease, which challenging its asymptomatic course at early stages lack objective diagnostic approaches. Recent studies revealed that pathophysiology includes complex...
Wilson’s disease (WD) is a rare autosomal recessive metabolic disorder resulting from mutations in the copper-transporting, P-type ATPase gene ATP7B gene, but influences of epigenetics, environment, age, and sex-related factors on WD phenotype complicate diagnosis clinical manifestations. Oxylipins, derivatives omega-3, omega-6 polyunsaturated fatty acids (PUFAs) are signaling mediators that deeply involved innate immunity responses; regulation inflammatory responses, including acute chronic...