A5103253973- Health Systems, Economic Evaluations, Quality of Life
- Antibiotics Pharmacokinetics and Efficacy
- Functional Brain Connectivity Studies
- Pharmaceutical Economics and Policy
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Genomics and Rare Diseases
- Pharmaceutical industry and healthcare
- Parkinson's Disease Mechanisms and Treatments
- Pharmaceutical studies and practices
- Epilepsy research and treatment
- Neurological disorders and treatments
- Schizophrenia research and treatment
- Computational Drug Discovery Methods
- Botulinum Toxin and Related Neurological Disorders
- Brain Tumor Detection and Classification
- Neurological Disease Mechanisms and Treatments
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Alzheimer's disease research and treatments
- Pharmacogenetics and Drug Metabolism
- Antimicrobial Resistance in Staphylococcus
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Aix-Marseille Université
2016-2025
Inserm
2019-2025
Hôpital de la Timone
2005-2025
Institut de Neurosciences des Systèmes
2016-2025
Institut de Neurophysiopathologie
2023-2024
French Clinical Research Infrastructure Network
2020-2024
Centre National de la Recherche Scientifique
2012-2023
Institut National de Recherches Archéologiques Préventives
2007-2023
Archéologies et Sciences de l’Antiquité
2007-2023
Maison des Sciences de l'Homme Mondes
2012-2023
The effect of placing parallel lines on the walking surface parkinsonian gait was evaluated. To identify kind visual cues (static or dynamic) required for control locomotion, we tested two conditions: normal lighting and stroboscopic illumination (three flashes/s), latter acting to suppress dynamic completely. Sixteen subjects with idiopathic Parkinson's disease (nine males, seven females; mean age 68.8 years) same number age-matched controls (seven males; nine females, 67.5 were studied....
We studied the effects of intravenous immunoglobulin (IVIg) in 12 patients with motor neuron syndromes associated high titers anti-GM1 antibodies. Five had conduction blocks. The study design was a double-blind, placebo-controlled, crossover trial IVIg (0.4 g/kg body weight per day injected for 5 consecutive days). evaluated before and 5, 28, 56 days after drug administration using computerized analyzer muscle strength, Norris scale disability, nerve velocities blocks, measurements...
Though rare diseases affect fewer patients than common diseases, developing drugs for them is subject to the same principles. But constructing and leading clinical trials means also facing numerous difficulties which are more important in this field (methodology, little knowledge of disease’s evolution, choice judgment’s criteria, small population’s size, logistical matters...) However during last decade, France led several initiatives improve burden diseases. Centres Expertise were...
The cortico-limbic system is critically involved in emotional responses and resulting adaptive behaviors. Within this circuit, complementary regions are believed to be either the appraisal or regulation of affective state. However, respective contribution these bottom-up top-down mechanisms during emotion processing remains clarified. We used a new functional magnetic resonance imaging (fMRI) paradigm varying 3 parameters: valence, congruency, allocation attention, distinguish variation...
Drug repurposing is the process of identifying a new use for an existing drug or active substance in indication outside scope original indication. has important advantages including reduced development time and costs, potentially large societal healthcare cost savings. However, current generic research faces number challenges obtaining funds. Furthermore, regardless success trial, commercial parties often lack interest pursuing marketing authorisation financial reasons, academic researchers...
Abstract Purpose Doctor‐shopping (simultaneous use of several physicians by a patient) is one the most frequent ways diversion for prescription drugs. A specific method was used to assess evolution doctor‐shopping High Dosage Buprenorphine (HDB) in French region from 2000 2005 and impact monitoring program HDB implemented 2004. Methods Data eight periods (semesters years 2000, 2002, 2004, 2005) were extracted database. Three quantities (the delivered, prescribed, quantity) computed each...
Drug repurposing, the process of identifying new uses for existing drugs beyond their original indications, offers significant advantages in terms reduced development time and costs, particularly addressing unmet medical needs rare diseases. Artificial intelligence (AI) has emerged as a transformative force healthcare, by leveraging AI technologies, researchers aim to overcome some challenges associated with This review presents concrete case studies, well pre-existing platforms,...
Objective Psychosocial trauma during childhood is associated with schizophrenia vulnerability. The pattern of grey matter decrease similar to brain alterations seen in schizophrenia. Our objective was explore the links between trauma, morphology and symptoms. Method Twenty‐one patients stabilized atypical antipsychotic monotherapy 30 healthy control subjects completed study. Anatomical MRI images were analysed using optimized voxel‐based morphometry ( VBM ). Childhood assessed Trauma...
Abstract Converging evidence points to a link between anxiety proneness and altered emotional functioning, including threat‐related biases in selective attention higher susceptibility emotionally ambiguous stimuli. However, during these complex situations, it remains unclear how trait affects the engagement of prefrontal control system particularly anterior cingulate cortex (ACC), core region at intersection limbic systems. Using an conflict task functional magnetic resonance imaging (fMRI),...
Local anesthetic systemic toxicity (LAST) has been reported as a serious complication of local (LA) peripheral injection. The signs and symptoms LAST are highly variable, the challenge remains to confirm its diagnosis. In this context, determination LA plasma concentration appears valuable tool aims study were describe observed concentrations in patients suspected with their contribution diagnostic confirmation.We retrospectively for which at least one was determined diagnosis LAST. Data...
AbstractThe diagnosis constraint of acute stress disorder (ASD), consisting testing individuals in the month following trauma exposure, limits research on very early and initial stage disease. In this regard, work aims to explore cerebral mechanism ASD a population fire-fighters before after exposure. Thirty-six healthy non-traumatized male were explored by an fMRI emotional face-matching task evaluate substrate recognition. During two years follow-up, subjects traumatized, thus retested, as...
Owing to a similar cerebral neuro-anatomy, non-human primates are viewed as the most valid models for understanding cognitive deficits. This study evaluated psychomotor and mnesic functions of 41 young old mouse lemurs (Microcebus murinus). Psychomotor capacities anxiety-related behaviors decreased abruptly from middle late adulthood. However, Mnesic were not affected in same way with increasing age. While results spontaneous alternation task point progressive widespread age-related decline...