A5028117057- Memory and Neural Mechanisms
- Posttraumatic Stress Disorder Research
- Anesthesia and Neurotoxicity Research
- Schizophrenia research and treatment
- Traumatic Brain Injury Research
- Psychoanalysis and Psychopathology Research
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychosomatic Disorders and Their Treatments
- Grief, Bereavement, and Mental Health
- Health, Medicine and Society
- Traumatic Brain Injury and Neurovascular Disturbances
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sleep and Wakefulness Research
- Neurology and Historical Studies
- Pain Management and Placebo Effect
- Hearing Loss and Rehabilitation
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Homicide, Infanticide, and Child Abuse
- Sleep and Work-Related Fatigue
- Historical and Scientific Studies
Aix-Marseille Université
2015-2021
Centre National de la Recherche Scientifique
2015-2021
Laboratoire de Neurosciences Cognitives
2019-2021
Institut de Neurosciences de la Timone
2013-2018
Hôpital d'Instruction des Armées Sainte-Anne
2013-2017
Institut de Médecine Tropicale du Service de Santé des Armées
2014
Hôpital de Jolimont
1988
Objective Psychosocial trauma during childhood is associated with schizophrenia vulnerability. The pattern of grey matter decrease similar to brain alterations seen in schizophrenia. Our objective was explore the links between trauma, morphology and symptoms. Method Twenty‐one patients stabilized atypical antipsychotic monotherapy 30 healthy control subjects completed study. Anatomical MRI images were analysed using optimized voxel‐based morphometry ( VBM ). Childhood assessed Trauma...
Abstract Converging evidence points to a link between anxiety proneness and altered emotional functioning, including threat‐related biases in selective attention higher susceptibility emotionally ambiguous stimuli. However, during these complex situations, it remains unclear how trait affects the engagement of prefrontal control system particularly anterior cingulate cortex (ACC), core region at intersection limbic systems. Using an conflict task functional magnetic resonance imaging (fMRI),...
Objective: Neurobiological models of Posttraumatic Stress Disorder (PTSD) implicate fear processing impairments in the maintenance disorder. Eye Movement Desensitization and Reprocessing (EMDR) is one most efficient psychotherapies to treat PTSD. We aimed at exploring brain mechanisms circuitry involved PTSD patients' symptom remission after EMDR therapy.Method: Thirty-six participants were randomly assigned either group receiving therapy or Wait-List (WL) supportive therapy. Participants...
Recent studies suggest that Posttraumatic Stress Disorder (PTSD) might be associated with dysfunctional reward circuitry. However, further research is needed to understand the key role of system in PTSD symptomatology.Twenty participants and 21 Trauma-Exposed matched Controls (TECs) completed Monetary Incentive Delay (MID) task during an MRI session. Reaction times (RTs) hit rates were recorded. Brain activity was investigated anticipation outcome monetary gains losses.During loss, had...
Introduction: The inability to extinguish a conditioned fear is thought be at the core of post-traumatic stress disorder. Eye movement desensitization and reprocessing therapy has been efficacious for disorder, but brain mechanisms underlying effect are still unknown. eye seems rely on simultaneous association bilateral alternating stimulation recall traumatic memory. To shed light how functions, we aimed highlight structures activated by during extinction its recall. Methods: We included 38...
Disruption of fear conditioning, its extinction and retrieval are at the core Posttraumatic Stress Disorder (PTSD). Such deficits, especially delay, disappear after Alternating Bilateral Stimulations (BLS) during Eye Movement Desensitization Reprocessing (EMDR) therapy. An animal model recovery, based on auditory cued conditioning learning, recently showed that BLS facilitate retrieval. Our goal was to determine if these previous results found in animals can be reproduced humans. Twenty-two...
We recently reported an improvement of precuneus PET metabolism after EMDR therapy in military participants suffering from PTSD. The aim the present study was to investigate metabolic changes connectivity these such treatment. Fifteen with PTSD performed a brain 18F-FDG-PET sensitized by virtual reality exposure war scenes, before and Inter-regional correlation analysis through SPMT maps at whole-brain level (p < 0.005 for voxel, p 0.05 cluster). A decrease observed between two significant...
Abstract Eye movement desensitization and reprocessing (EMDR) is a psychotherapy for the treatment of posttraumatic stress disorder (PTSD). It still unclear whether symptoms remission through EMDR therapy associated with beneficial effect on one PTSD symptoms, sleep disturbance. Our objective was therefore to study parameters before after symptom in soldiers PTSD. The control group consisted 20 healthy active duty military men who slept lab standard polysomnography (PSG) two sessions...
Post-Traumatic Stress Disorder (PTSD) affects nearly 10% of soldiers leaved waging war. So far, there is no standard treatment for PTSD. The selective serotonin reuptake inhibitors (SSRIs) are considered the first-line pharmacological However, response rates rarely exceed 60% and less than 20-30% patients achieve full remission. Excessive brain responsiveness to norepinephrine appears play a significant role in onset A active alpha- 1 adrenergic receptor antagonist used treat benign...
Introduction La réponse normale ou pathologique à la peur peut être étudiée par un protocole de conditionnement et son extinction. Nous avons étudié les mécanismes cérébraux centraux réponses l’aide du modèle que constitue l’État Stress Post-Traumatique (ESPT), extinction en IRM fonctionnelle (IRMf). Notre hypothèse est si ce mécanisme conditionnement/extinction central dans l’ESPT, alors après disparition des symptômes, anomalies fonctionnelles structures impliquées (amygdale cortex...
L'état de stress post-traumatique (ESPT) dans le DSM5 est inclu l'ensemble trauma and stress-related disorders. L'ESPT interroge sur les mécanismes réponses à la peur ; comment un événement vie peut-il mettre mal ce système inné ? Ces pathologiques sont-elles préexistantes Sont-elles réversibles après traitement Dès 1927, Pavlov démontrait l'existence d'un réflexe appris suite protocole conditionnée. Depuis, centraux normaux ou sont étudiés l'aide conditionnement et son extinction. Celui-ci...
Pour les vétérans, commémorations sont un temps de reconnaissance publique et fraternité, mais pas d’apaisement. Elles peuvent même être particulièrement douloureuses chez celui pour qui événements la guerre prégnants comme au premier jour : chaque année, l’horreur lui est rappelée on attend qu’il témoigne ce a vécu, lutte oublier. ces vétérans blessés psychiques, autre peut tenir lieu commémoration l’expertise médicale. Dans moment, c’est à leur singularité que le médecin va s’intéresser.
Introduction Une controverse existe concernant la nature et l’origine des réductions de densité matière grise (dMG) dans l’État Stress Post-Traumatique (ESPT). Ces atrophies pourraient être facteurs vulnérabilité pour le développement l’ESPT [2] ou bien conséquence symptômes liés au traumatisme [1]. Le but cette étude a été d’étudier question. Notre hypothèse est que les principales décrites littérature évolueront avec l’amélioration une semaine 6 mois après thérapie désensibilisation...
In the United States of America, lifetime prevalence post-traumatic stress disorder (PTSD) varies between 8 and 11 %. The pathophysiology PTSD is complex, involving prefrontal cortex, limbic system which amygdala locus coeruleus. We don't have a specific treatment for this pathology but just symptomatic treatment. present review analyzes results referenced outcome studies in Medline. efficacity prazosin, an alpha-1 adrenergic antagonistis evidence to deregulation. Confirm hypothesis...
Introduction L’étude des facteurs de vulnérabilité à la schizophrénie est un enjeu majeur psychiatrie actuelle [3]. Nous avons donc réalisé une étude dans l’objectif d’expliciter les liens existant entre traumatismes subis l’enfance et anomalies anatomiques observées schizophrénie. Patients méthode Au total 26 sujets schizophrènes stabilisés par rispéridone ou aripiprazole depuis au moins 6 semaines 31 volontaires sains appariés ont été inclus. La sévérité infantiles a évaluée avec Childhood...