A5057713067- Posttraumatic Stress Disorder Research
- Substance Abuse Treatment and Outcomes
- Neurotransmitter Receptor Influence on Behavior
- Eating Disorders and Behaviors
- Migration, Health and Trauma
- Alcoholism and Thiamine Deficiency
- Treatment of Major Depression
- Schizophrenia research and treatment
- Obsessive-Compulsive Spectrum Disorders
- Personality Disorders and Psychopathology
- Resilience and Mental Health
- Alcohol Consumption and Health Effects
- Regulation of Appetite and Obesity
- Sleep and related disorders
- Tryptophan and brain disorders
- Suicide and Self-Harm Studies
- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Pain Management and Placebo Effect
- Nicotinic Acetylcholine Receptors Study
- Circadian rhythm and melatonin
- Anesthesia and Neurotoxicity Research
- Smoking Behavior and Cessation
VA Connecticut Healthcare System
2014-2024
Yale University
2014-2024
Mental Illness Research, Education and Clinical Centers
2008-2018
United States Department of Veterans Affairs
2014
National Institute on Alcohol Abuse and Alcoholism
2008-2013
University School
2012
Boston University
2010
Bridge University
1995
Toronto General Hospital
1993-1994
University of Toronto
1994
This study tracked the individual criteria of four DSM-IV personality disorders-borderline, schizotypal, avoidant, and obsessive-compulsive disorders-and how they change over 2 years. clinical sample patients with disorders was derived from Collaborative Longitudinal Personality Disorders Study included all participants borderline, or disorder for whom complete 24-month blind follow-up assessments were obtained (N=474). The authors identified rank-ordered each by their variation in...
Background Posttraumatic stress disorder (PTSD) is an important and timely clinical issue particularly for combat veterans. Few pharmacologic options are available to treat PTSD, among military personnel, they not based on rational neurobiology. The evidence noradrenergic dysregulation in PTSD strong, the alpha‐adrenergic agonist prazosin one of most promising medications sleep disturbances associated with as well symptoms both veterans civilians. Evidence also implicates pathophysiology...
Background The ethanol metabolites, ethyl glucuronide (EtG) and sulfate (EtS), are biomarkers of recent alcohol consumption that provide objective measures abstinence. Our goals to better understand the impact cutoff concentration on test interpretation, need for measuring both how best integrate results with self-reports in clinical trials. Methods Subjects (n = 18) were administered, 1 week apart, 3 doses calibrated achieve blood concentrations 20, 80, 120 mg/dl, respectively. Urinary...
Evidence indicates that feeding-related peptides, such as ghrelin, have a role in the rewarding properties of addictive substances like alcohol. Oral alcohol administration significantly suppresses ghrelin. This study was designed to evaluate effects two doses on ghrelin and examine if levels predict subjective Healthy social drinkers (N = 20) participated three, randomly assigned, counterbalanced laboratory sessions. During each session they received continuous IV infusion either placebo...
Objective: Existing evidence from anxiety disorder research indicates that social phobics (SP) with avoidant personality (AVPD) experience more and show impairment than patients SP alone. The purpose of this study was to examine whether in diagnosed AVPD, the co‐occurrence adds its severity. We hypothesized addition will not add severity AVPD Method: Two groups (AVPD = 224; AVPD/SP 101) were compared at baseline 2 years later on multiple demographic clinical variables. Results: Patients an...
Abstract Thirty-nine women who had miscarriages completed questionnaires within 3 months, and at 6 months 1 year following the miscarriage. Subjects Centre for Epidemiological Study Depression Scale (CES-D), Spanner Dyadic Adjustment (DAS), Rosenberg Self-Esteem Scale, Maffcr Feminine Identity two study questionnaires. Miscarriage a significant impact on most women's' lives over year, regardless of their age or presence other living children. scores were elevated after miscarriage, decreased...
Objective: Although disulfiram and naltrexone have been approved by the Food Drug Administration for treatment of alcoholism, no medications individuals with alcohol dependence comorbid psychiatric disorders. In particular, effect these on use outcomes specific symptoms is still unknown in patients most common co-occurring disorder, major depression. Method: Two hundred fifty-four a Axis I disorder were treated 12 weeks an outpatient medication study conducted at 3 Veterans clinics....
Background: The primary objective of this study was to determine whether healthy subjects without a history heavy alcohol use or family alcoholism exhibit concentration‐dependent analgesic effect ethanol. In preliminary fashion, we also compared sample group with strong positive for (FHP) test the secondary hypothesis that FHP individuals will be more sensitive effects who are negative (FHN). Methods: Forty‐one FHN and 19 participated. Test days included an ethanol high concentration...
Ghrelin, a feeding-related peptide mainly produced in the stomach, has been linked to reward mechanisms for food and drugs of abuse addition traits impulsivity. This study is secondary analysis an existing data set designed examine direct relationships between fasting ghrelin levels sensitivity/impulsivity healthy social drinkers.Participants (n = 20) were recruited from original examining subjective effects alcohol among drinkers. Fasting collected at baseline. Personality measures...
The study's objective was to determine the quality and severity of grief after spontaneous abortion statistically effect significant demographics social variables such as age, number previous losses perceived family support on experienced.Two hundred ninety-four women who had experienced a miscarriage within last year were participants. One seventy-five miscarried three months prior participation in study; one nineteen previously. Ninety-five percent approached consented participate....
Although there is good evidence of a relationship between certain personality factors (viz.neuroticism and hypochondriasis) in the reporting somatic symptoms-both clinical nonclinical research-the recognition moderating role individual differences frequency intensity side effect virtually absent from drug trial research. This study was double-blind moclobemide-versus-placebo trial, purpose which twofold: to investigate degree complaints sample healthy men women assess symptom reporting. no...
Pharmacologic and cognitive behavioral therapies have been advocated in the treatment of bulimia nervosa (BN). Brofaromine, a selective reversible inhibitor monoamine oxidase-A was selected for double-blind, placebo-controlled evaluation because previous demonstrated oxidase efficacy BN its safer adverse reaction profile. Thirty-six female patients who met DSM-III-R criteria were randomly assigned to drug group (N = 19) or placebo 17) an 8-week outpatient trial. Brofaromine produced...
Background Disulfiram and naltrexone were evaluated in treatment of individuals with co‐occurring alcohol dependence other Axis I disorders (e.g., Major Depression). We explored pharmacogenetic interactions genotyped subjects. Methods Alcohol dependent (AD) subjects received alone, placebo disulfiram or naltrexone. They for OPRM1 rs1799971 (Asn40Asp), DBH rs1611115 (C‐1021T). N = 107 male European‐American included. Results There no significant . interacted on the primary outcome abstinence...
Background Alcohol dependence ( AD ) and post‐traumatic stress disorder PTSD commonly co‐occur, the co‐occurrence is associated with worse prognosis than either absent other. Craving an important construct related to relapse, but relationship between symptoms, craving, relapse not well understood. Several studies have documented craving in individuals without comorbid , effect on those known. A small literature suggests that trauma imagery affects craving. This first study explore effects of...