A5043112650- Gene Regulatory Network Analysis
- Cancer-related Molecular Pathways
- stochastic dynamics and bifurcation
- Computational Drug Discovery Methods
- Microtubule and mitosis dynamics
- Nonlinear Dynamics and Pattern Formation
- Bioactive Compounds and Antitumor Agents
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Hepatitis C virus research
- Molecular Communication and Nanonetworks
- Garlic and Onion Studies
- Phytochemicals and Antioxidant Activities
- Photoreceptor and optogenetics research
- Essential Oils and Antimicrobial Activity
- Marine and coastal ecosystems
- Spectroscopy and Quantum Chemical Studies
- thermodynamics and calorimetric analyses
- Ginger and Zingiberaceae research
- Morinda citrifolia extract uses
- Advanced Drug Delivery Systems
- Bioinformatics and Genomic Networks
- Parasitic Diseases Research and Treatment
- Botanical Research and Chemistry
University of Ha'il
2015-2025
Louisiana State University Health Sciences Center Shreveport
2017-2025
Comanche County Juvenile Bureau
2023
Memorial Hospital
2023
Weatherford College
2022
Fidal
2022
Texas Health Dallas
2020
Jamia Millia Islamia
2010-2019
Guy's and St Thomas' NHS Foundation Trust
2019
Jawaharlal Nehru University
2014-2015
The organic-inorganic hybrid compound (2-HAP)2[CoBr4], (2-HAP=2-protonated aminopyridinium cation) was characterized by various physicochemical techniques. Hirshfeld surfaces and 2D fingerprint plots reveal the intermolecular interactions accountable for generation of crystal packing. differential scanning calorimetric (DSC) disclosed three phase transitions at T1=61.9 °C, T2=107.6 °C T3=172 °C. electronic parameters such as frontier molecular orbitals, HOMO-LUMO energy electrochemical band...
In this study, the antioxidant and anti-inflammatory effects of Zingiber officinale roscoe Allium subhirsutum aqueous extracts were examined in a carrageenan-induced acute inflammation model. Some markers such as hematological parameters, fibrinogen C-reactive protein measured. Variables reflecting oxidative stress included thiobarbituric acid reactive substances (TBARS), advanced oxidation products (AOPP), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) determined...
Diabetes mellitus is a multifactorial disease that affects both developing and developed countries major public health concern. Many synthetic drugs are available in the market, which counteracts associated pathologies. However, due to propensity of side effects, there an unmet need for investigation safe effective drugs. This research aims find novel phytoconstituent having diminished action on blood glucose levels with least effects. Shikonin naturally occurring naphthoquinone dying...
Fighting against the emergent coronavirus disease (COVID-19) remains a big challenge at front of world communities. Recent research has outlined potential various medicinal herbs to counteract infection. This study aimed evaluate interaction artemisinin, sesquiterpene lactone extracted from Artemisia genus, and its derivatives with SARS-CoV-2 main protease. To assess their use COVID-19, interactions active principle severe acute respiratory syndrome 2 (SARS-CoV-2) protease (Mpro) was...
Abstract Background Invasive aspergillosis is a life-threatening infection that affects immunocompromised hosts. Cardiac involvement rare, but it associated with high-mortality rate. Most cases reported infective endocarditis secondary to Aspergillus. However, there limited data about non-valvular cardiac (NVCA). We performed systematic review and added one case seen at our institution highlight more on NVCA. PRISMA Flow Diagram NVCA Methods Three reviewers searched PUBMED EMBASE for all...
Abstract Background The concomitant use of vancomycin (Vanc) and piperacillin-tazobactam (Pip/Tazo) is one the most common combinations utilized in infectious disease field. But, studies have hinted at an increased risk nephrotoxicity. However, specific factors leading to development acute kidney injury (AKI) remain uncertain. In this study, we sought elucidate potential contributing AKI pts who received both Vanc Pip/Tazo Methods We performed a retrospective study adult admitted Ochsner LSU...
Background: Syzygium aromaticum is a tree whose aromatic dried flower buds are known as cloves. When it comes to phenolic chemicals, such flavonoids, hydroxybenzoic acids, hydroxycinnamic and hydroxyphenyl propane, clove major plant source of these substances. Finding out how effective antioxidants was the driving force behind this study’s GC-MS investigation computational discoveries. Methods: This inquiry into pods focused on chemical composition using technique, well its antioxidant...
Lung cancer is one of the leading causes cancer-related deaths worldwide. Non-Small Cell Cancer (NSCLC) represents a predominant subset lung cases with pressing need for innovative therapeutic strategies. Plumbagin, naturally occurring naphthoquinone, has been investigated its pharmacokinetic properties and potential anti-cancer effects, particularly against NSCLC. This study encompasses in-silico analysis plumbagin's profile, molecular interaction caspase-9 protein, subsequent dynamic...
Diabetes is a complicated multifactorial disorder in which the patient generally observes polyphagia, polydipsia, and polyuria due to uncontrolled growth blood sugar levels. For its management, pharmaceutical industry working day night find better drug with no or least toxicity. That's why nowadays more focused branch use herbal phytoconstituents for prevention. Shikonin naphthoquinone natural dye that isolated from plants of Boraginaceae family has proven role as an anti-cancer,...
Considering the urgency of COVID-19 pandemic, we developed a receptor-based pharmacophore model for identifying FDA-approved drugs and hits from natural products. The main protease (Mpro) was selected development model. consisted hydrogen bond acceptor, donor, hydrophobic features. These features demonstrated good corroboration with previously reported that used to validate present model, showing an RMSD value 0.32. virtual screening carried out using ZINC database. A set 208,000 extracted...
Introduction The Hail Desert Plant Database serves as an extensive repository that has been created to consolidate and systematize information concerning medicinal plants are native the arid region in Saudi Arabia. Materials Methods By conducting thorough literature mining from credible sources such scientific articles online databases, we systematically collected organized data on more than 200 desert plant species. This comprehensive dataset includes botanical characteristics,...
SARS-CoV-2 is a positive-stranded RNA virus that bundles its genomic material as messenger-sense in infectious virions and replicates these genomes through intermediates. Several virus-encoded nonstructural proteins play key role during the viral life cycle. Endoribonuclease NSP15 vital for replication cycle of virus, thus considered compelling druggable target. Here, we performed combination multiscoring virtual screening molecular docking library 1624 natural compounds (Nuclei Bioassays,...
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The nuclear matrix associated protein SMAR1 is sensitive to p53 and acts as a stress inducer well regulator in the regulatory network. Depending on amount of stimulates, it can drive dynamics system various dynamical states which correspond cellular states. behavior these found be multifractal, due mostly long range correlations large scale fluctuations imparted by stress. This fractal exhibited topological properties networks constructed from states, signature self-organization optimize...
We construct a stress p53-Mdm2-p300-HDAC1 regulatory network that is activated and stabilised by two proteins, p300 HDAC1. Different activation levels of observed due to these regulators during condition have been investigated using deterministic as well stochastic approach understand how the cell responds conditions. found help in adjusting p53 different conditions identified various oscillatory states, namely fixed point oscillations, damped oscillations sustain oscillations. On assessing...