A5058285169- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Plant Disease Resistance and Genetics
- Chromosomal and Genetic Variations
- Plant Reproductive Biology
- Plant Virus Research Studies
- Plant nutrient uptake and metabolism
- Genomics and Chromatin Dynamics
- Plant-Microbe Interactions and Immunity
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA and protein synthesis mechanisms
- Marine and coastal plant biology
- RNA Research and Splicing
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Reproductive biology and impacts on aquatic species
- Silicon Effects in Agriculture
- MicroRNA in disease regulation
- Plant Gene Expression Analysis
- Plant Pathogens and Resistance
- Plant responses to elevated CO2
- Nuclear Structure and Function
- Skin Protection and Aging
- Acne and Rosacea Treatments and Effects
- Ubiquitin and proteasome pathways
James Hutton Institute
2024
University of Dundee
2024
Max Planck Institute for Biology
2023-2024
Max Planck Institute for Developmental Biology
2018-2024
University of Cambridge
2015-2023
Sainsbury Laboratory
2014-2019
University of Tübingen
2018
Chemical Genomics Centre
2018
Max Planck Society
2018
European Committee for Standardization
2018
Plant survival under environmental stress requires the integration of multiple signaling pathways into a coordinated response, but molecular mechanisms underlying this are poorly understood. Stress-derived energy deprivation activates Snf1-related protein kinases1 (SnRK1s), triggering vast transcriptional and metabolic reprogramming that restores homeostasis promotes tolerance to adverse conditions. Here, we show two clade A type 2C phosphatases (PP2Cs), established repressors abscisic acid...
The inverse correlation between skin pigmentation and latitude observed in human populations is thought to have been shaped by selective pressures favoring lighter facilitate vitamin D synthesis regions far from the equator. Several candidate genes for shown exhibit patterns of polymorphism that overlap geospatial variation color. However, little work has focused on estimating time frame over which changed intensity selection acting different genes. To provide a temporal framework evolution...
Temperature is a key environmental variable influencing plant growth and survival. Protection against high temperature stress in eukaryotes coordinated by heat shock factors (HSFs), transcription that activate the expression of protective chaperones such as HEAT SHOCK PROTEIN 70 (HSP70); however, pathway which sensed integrated with other signals into adaptive responses not well understood. Plants are exposed to considerable diurnal variation temperature, we have found there thermotolerance...
In many eukaryotes, genetic sex determination is not governed by XX/XY or ZW/ZZ systems but a specialized region on the poorly studied U (female) V (male) chromosomes. Previous studies have hinted at existence of dominant male-sex factor chromosome in brown algae, group multicellular eukaryotes distantly related to animals and plants. The nature this has remained elusive. Here, we demonstrate that an HMG-box gene acts as male-determining mirroring role genes play animals. Over billion-year...
ABSTRACT In many animals and flowering plants, sex determination occurs in the diploid phase of life cycle with XX/XY or ZW/ZZ chromosomes. However, early diverging plants most macroalgae, is determined by female (U) male (V) chromosomes a haploid called gametophyte. Once U V unite at fertilization to produce sporophyte, no longer occurs, raising key questions about fate sporophyte phase. Here, we investigate genetic molecular interactions UV both phases brown alga Ectocarpus. We reveal...
Intron splicing increases proteome complexity, promotes RNA stability, and enhances transcription. However, introns the concomitant need for extend time required gene expression can cause an undesirable delay in activation of genes. Here, we show that plant microRNA processing factor SERRATE (SE) plays unexpected pivotal role regulation intronless Arabidopsis SE associated with more than 1000, mainly intronless, genes a transcription-dependent manner. Chromatin-bound liaised paused...
The SnRK1 protein kinase, the plant ortholog of mammalian AMPK and yeast Snf1, is activated by energy depletion caused adverse environmental conditions. Upon activation, triggers extensive transcriptional changes to restore homeostasis promote stress tolerance survival partly through inhibition anabolism activation catabolism. Despite identification a few bZIP transcription factors as downstream effectors, mechanisms underlying gene regulation, in particular repression SnRK1, remain mostly...
SignificanceParamutation involves the transfer of a repressive epigenetic mark between silent and active alleles. It is best known from exceptional non-Mendelian inheritance conspicuous phenotypes in maize but also other plants animals. Recent genomic studies, however, indicate that paramutation may be less exceptional. consequence wide-cross hybridization contribute to quantitative trait variation or unstable crops. Using sulfurea (sulf) locus tomato, we demonstrate self-reinforcing...
Abstract The alternation between multicellular haploid gametophytes and diploid sporophytes is a defining feature of most plant algal life cycles. In such organisms, male female sexes are determined in the gametophyte with (U) or (V) sex chromosome. Once U V chromosomes unite at fertilisation, determination no longer occurs, raising key questions about fate UV sporophyte stage cycle. Here, we unravel genetic molecular interactions by assessing transcriptional chromatin states across cycle...
Abstract The decision of whether to grow and proliferate or restrict growth develop resilience stress is a key biological trade-off. In plants, constitutive results in increased sensitivity environmental 1,2 . underlying mechanisms controlling this are however not well understood. We used temperature as cue discover regulators process it both enhances development rates within specific range also at extremes. found that the conserved chromatin-associated protein DEK plays central role...
Abstract Nuclear three dimensional (3D) folding of chromatin structure has been linked to gene expression regulation and correct developmental programs, but little is known about the 3D architecture sex chromosomes within nucleus, how that impacts their role in determination. Here, we determine sex-specific organization model brown alga Ectocarpus at 2 kb resolution, by mapping long-range chromosomal interactions using Hi-C coupled with Oxford Nanopore long reads. We report interphase...
Abstract Sex chromosomes are unique genomic regions displaying structural and evolutionary features that distinguish them markedly from autosomes. Although nuclear three dimensional (3D) folding of chromatin structure is im-portant for gene expression regulation correct developmental programs, very little known about the 3D architecture sex within nucleus, how impacts their function in determination. Here, we determine sex-specific organization model brown alga Ectocarpus at 2 kb resolution,...
Diagnóstico de equilíbrios entre Património, habitação e
Abstract Paramutation involves the transfer of a repressive epigenetic mark from silent allele to an active homologue and, consequently, non-Mendelian inheritance. In tomato sulfurea ( sulf ) paramutation is associated with high level CHG hypermethylation in region overlapping transcription start site SlTAB2 gene that affects chlorophyll synthesis. The CCG sub-context under-represented at this relative CTG or CAG implicating CHROMOMETHYLTRANSFERASE3 (CMT3) locus. Consistent interpretation,...