A5041099702- Air Quality and Health Impacts
- Energy and Environment Impacts
- Heme Oxygenase-1 and Carbon Monoxide
- Epigenetics and DNA Methylation
- Adipose Tissue and Metabolism
- Veterinary Pharmacology and Anesthesia
- Pain Mechanisms and Treatments
- Histone Deacetylase Inhibitors Research
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Pain Management and Opioid Use
- Glaucoma and retinal disorders
- Health, Environment, Cognitive Aging
- Retinal Development and Disorders
- Childhood Cancer Survivors' Quality of Life
- Birth, Development, and Health
- Climate Change and Health Impacts
- Fire effects on ecosystems
Colorado State University
2024
Boise State University
2020-2023
Northeast Ohio Medical University
2022
Wildfires are now a common feature of the western US, increasing in both intensity and number acres burned over last three decades. The effects this changing wildfire smoke landscape critical public occupational health issue. While respiratory morbidity due to exposure is priority, evaluating molecular underpinnings that explain recent extrapulmonary observations necessary. Here, we use an Apoe
Background: Visual disturbances often precede cognitive dysfunction in patients with Alzheimer’s disease (AD) and may coincide early accumulation of amyloid-β (Aβ) protein the retina. These findings have inspired critical research on vivo ophthalmic Aβ imaging for biomarker detection but not fully answered mechanistic questions how retinal pathology affects visual signaling between eye brain. Objective: The goal this study was to provide a functional structural assessment eye-brain...
Abstract Wildfires have become common global phenomena concurrent with warmer and drier climates are now major contributors to ambient air pollution worldwide. Exposure wildfire smoke has been classically associated adverse cardiopulmonary health outcomes, especially in vulnerable populations. Recent work expanded our understanding of toxicology include effects on the central nervous system reproductive function; however, neurotoxic profile this toxicant remains ill-explored an occupational...
Due to the high prevalence of opioid prescription following orthopedic procedures, there is a growing need establish an animal model system evaluate effects opioids on bone remodeling. Rabbits have been employed as organisms in research they exhibit well-defined cortical remodeling similar humans. Existing rabbits has limited modes administration that are short-acting and require repeated application. Here, we present data from proof-of-principle longitudinal study employing two analgesic...
Wildfire events are increasing across the globe. The smoke generated as a result of this changing fire landscape is potentially more toxic than air pollution from other ambient sources, according to recent studies. This especially concerning for populations humans or animals that live downwind areas burn frequently, given exposure wildfire cannot be easily eliminated. We hypothesized significant indoor risk existed laboratory animal facilities located proximal fire-prone areas. Here, we...
With wildfires increasing in activity the Western United States and around world, there is an immediate need to understand toxic effects of smoke. This chapter will provide a background toxicology apply principle concepts such as dose, duration frequency help define potential smoke exposure. Characteristics that influence toxicity be discussed, which include particle size, source temperature mixture chemical constituents. An overview routes exposure, mechanisms action, toxicokinetics role...