A5002190189- Pancreatic and Hepatic Oncology Research
- Renal Diseases and Glomerulopathies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Genetic Neurodegenerative Diseases
- Gastrointestinal disorders and treatments
- Gallbladder and Bile Duct Disorders
- Olfactory and Sensory Function Studies
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Mitochondrial Function and Pathology
- Cell Adhesion Molecules Research
- Colorectal and Anal Carcinomas
- Renal cell carcinoma treatment
- Genetic and Kidney Cyst Diseases
- Colorectal Cancer Screening and Detection
- Photochromic and Fluorescence Chemistry
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Neurogenesis and neuroplasticity mechanisms
- Gastrointestinal Tumor Research and Treatment
Kitasato University
2015-2024
Nakadōri General Hospital
2009-2023
Integrated Oncology (United States)
2021
Keio University
2021
Shinshu University
2021
Juntendo University
2021
RIKEN BioResource Research Center
2021
University of Tsukuba
2021
National Cancer Center Hospital East
2014-2017
Hokkaido University
1995-2015
Background and study aim Endoscopic submucosal dissection (ESD) is known as a curative treatment for colorectal superficial neoplasms. There however need more long-term clinical data to establish the full advantages of ESD regarding very low recurrence rates. The this retrospective was determine outcomes ESD. Methods A total 423 lesions treated by adenoma/dysplasia or adenocarcinoma between 1998 2008 at single high volume referral center were included. We conducted survey on patients with...
Identification of prognostic markers is important to establish a perioperative therapeutic strategy for resectable cholangiocarcinoma (CC). The aim this study was investigate whether serum carbohydrate antigen 19-9 (CA19-9) levels can predict survival patients who underwent surgical resection CC.The included 106 CC. Serum CA19-9 were measured preoperatively after biliary drainage and postoperatively about 4 weeks surgery. association clinicopathological factors (including levels) with...
In recent years, nonalcoholic fatty liver disease (NAFLD) after pancreatoduodenectomy (PD) has become increasingly problematic. Our aims were to clarify the relationship between NAFLD and postoperative pancreatic exocrine function identify risk factors for PD.Patients who underwent PD (n = 104) assessed with abdominal unenhanced computed tomography (CT) determine changes given a (13) C-labeled mixed triglyceride breath test measure function. The percent CO2 cumulative dose at 7 hr (% C cum...
Abstract Olfactory bulb (OB) interneurons are derived primarily postnatally from progenitors in the anterior subventricular zone (SVZa) and migrate to OB rostral migratory stream (RMS). Progenitors differentiate into phenotypically diverse granule periglomerular cells by as yet undefined mechanisms. To visualize spatiotemporal aspects of dopamine (DA) neuron differentiation, two independently transgenic mouse lines were analyzed with a 9‐kb tyrosine hydroxylase (TH) promoter drive either...
<b><i>Backgrounds/Aim:</i></b> Colorectal laterally spreading tumors (LSTs) are sometimes difficult to visualize even with image-enhanced endoscopy. &#947;-Glutamyl-transpeptidase (GGT) is a cell surface-associated enzyme that overexpressed in various types of human cancers. Furthermore, GGT expression higher colorectal cancer cells than normal mucosa. &#947;-Glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), an activatable fluorescent probe, nonfluorescent...
Patients with inflammatory bowel disease (IBD) who experience long-term chronic inflammation of the colon are at an increased risk developing colorectal cancer (CRC). Mitotic spindle positioning (MISP), actin-binding protein, plays a role in mitosis and positioning. MISP is found on apical membrane intestinal mucosa helps stabilize elongate microvilli, offering protection against colitis. This study explored tumorigenesis using database, human CRC cells, mouse model for colitis-induced...
Abstract The mechanisms underlying dopamine (DA) phenotypic differentiation in the olfactory bulb (OB) have not yet been fully elucidated and are subject of some controversy. OB DA interneurons destined for glomerular layer were shown to originate subventricular zone (SVZ) rostral migratory stream (RMS). current study investigated whether calcium/calmodulin‐dependent protein kinase IV (CaMKIV) either alone or together with Ets transcription factor ER81 was necessary determination during...
The aim of this study was to investigate the predictive and prognostic values intratumoural human equilibrative nucleoside transporter 1 (hENT1) ribonucleotide reductase subunit (RRM1) expression in advanced cholangiocarcinoma patients treated with adjuvant gemcitabine-based chemotherapy (AGC).Intratumoural hENT1 RRM1 levels were investigated immunohistochemically 127 who underwent surgical resection (68 AGC 59 without AGC). impacts on survival evaluated.High observed 86 (68%) 67 (53%)...
Abstract Background The indicators for proper drain management following pancreaticoduodenectomy (PD) remain unclear. Our aim was to identify appropriate timing and safe after PD. Methods Prospectively collected data from 200 patients who underwent PD were evaluated. Postoperative clinical factors clinically relevant pancreatic fistulas (CR‐POPFs) of surgically placed drains analyzed retrospectively. Results CR‐POPFs occurred in 8% patients. By logistic regression analysis, one factor...
IL-36α, a member of the IL-1 family, is crucial mediator inflammatory responses. We previously found that IL-36α was overexpressed in injured distal tubules (DTs); however, its pathological function remains unclear. Herein, unilateral ureter obstruction (UUO) or folic acid (FA) injection performed mouse kidneys to assess role kidney injury. mRNA and protein expression significantly increased within 24 h after UUO. localized dilated DTs. correlated with progression tubulointerstitial cell...
The aim of this study was to determine the impact preoperative biliary drainage (PBD) on long-term survival in patients with pancreatic head carcinoma after surgical resection.Medical records 160 who underwent resection were reviewed retrospectively. Clinicopathological parameters including compared between did and not undergo PBD.Overall PBD (n = 93) significantly worse than that 67) by univariate analysis (P 0.030). However, multivariate revealed an independent prognostic factor for...
Study Design. A case report. Objectives. To report the of a child with os odontoideum associated cerebellar infarction and to discuss correlation between atlantoaxial instability vertebrobasilar artery insufficiency. Summary Background Data. Knowledge influence on insufficiency remains limited despite publication several reports. Methods. 5-year-old boy ataxic gait disturbance was hospitalized in pediatric ward. Magnetic resonance imaging revealed multiple infarctions, cerebral angiogram...
Tensin2 (Tns2) is thought to be a component of the cytoskeletal structures linking actin filaments with focal adhesions and known play role as an intracellular signal transduction mediator through integrin in podocytes, although mechanism by which it functions remains unclear. A Tns2-null mutation (nph) leads massive albuminuria following podocyte foot process effacement ICGN mice, origin mutation, DBA/2J (D2) but not C57BL/6J (B6) mice or 129+Ter/SvJcl (129T) mice. Elucidating reasons for...
Podocytes are terminally differentiated and highly specialized cells in the glomerulus, they form a crucial component of glomerular filtration barrier. The ICGN mouse is model dysfunction that shows gross morphological changes podocyte foot process, accompanied by proteinuria. Previously, we demonstrated proteinuria ICR-derived glomerulonephritis mice might be caused deletion mutation tensin2 (Tns2) gene (designated Tns2nph). To test whether this causes mutant phenotype, created knockout...
<b><i>Background:</i></b> Membranous proliferative glomerulonephritis (MPGN) is a major primary cause of chronic kidney disease (CKD). Podocyte injury crucial in the pathogenesis glomerular with proteinuria, leading to CKD. To assess podocyte injuries MPGN, pathological features spontaneous murine models were analyzed. <b><i>Methods:</i></b> The autoimmune-prone mice strains BXSB/MpJ-<i>Yaa</i> and...
Abstract γ‐Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from subventricular zone (SVZ), but role GABA in differentiation these has been largely unexplored. This study examines OB dopaminergic interneurons using neonatal forebrain organotypic slice cultures prepared transgenic mice expressing green fluorescent protein (GFP) under control tyrosine hydroxylase ( Th ) gene promoter GFP). KCl‐mediated depolarization...
Most mitochondrial diseases are hereditary and highly heterogeneous. Cattle born with the V79L mutation in isoleucyl-tRNA synthetase 1 (IARS1) protein exhibit weak calf syndrome. Recent human genomic studies about pediatric also identified mutations IARS1 gene. Although severe prenatal-onset growth retardation infantile hepatopathy have been reported such patients, relationship between IARS symptoms is unknown. In this study, we generated hypomorphic IARS1V79L mutant mice to develop an...
Circadian rhythms are endogenous oscillators that regulate 24 h behavioral and physiological processes. Our previous investigation demonstrated bromobenzene metabolite (4-bromocatechol: 4-BrCA) exhibited chronotoxicity (i.e., the nephrotoxicity induced by 4-BrCA was observed during dark phase, while not at light phase in mice). However, molecular mechanism is still unknown. The aim of present study to investigate cellular molecule(s) involved 4-BrCA-induced using mouse renal cortex tubular...