A5040052859- Osteoarthritis Treatment and Mechanisms
- Collagen: Extraction and Characterization
- Knee injuries and reconstruction techniques
- Inflammatory mediators and NSAID effects
- Total Knee Arthroplasty Outcomes
- Spine and Intervertebral Disc Pathology
- Lower Extremity Biomechanics and Pathologies
- Chemokine receptors and signaling
- Bone health and osteoporosis research
- Silk-based biomaterials and applications
- Automotive and Human Injury Biomechanics
State Research Institute Centre for Innovative Medicine
2020-2024
The present study aims to explore the stressed state of cartilage using various meniscal tear models. To perform this research, anatomical model knee joint was developed and nonlinear mechanical properties meniscus were verified. stress–strain curve obtained by testing fresh tissue specimens human a compression machine. results showed that more deteriorated had greater stiffness, but its integrity greatest impact on growth stresses. confirm this, cases radial, longitudinal, complex tears...
Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no effective treatments are currently available. Arterial hypertension is common comorbidity in OA patients, and antihypertensive drugs, such nifedipine (NIF), may affect course progression. The aim this preclinical study was to determine effect healthy cartilage, depending its route administration. In study, we used destabilization medial meniscus develop mouse model OA. Nifedipine applied per os or...
The investigation examines the transference of stiffness from intervertebral discs (IVDs) to lumbar body L1 vertebra and interactions among adjacent tissues. A computational model was developed, considering parameters such as cortical bone thickness, trabecular elasticity, nonlinear response nucleus pulposus external loading. dynamic analysis performed, revealing certain trends: a heightened annulus fibrosus correlates with significant reduction in vertebral body’s ability withstand At...