A5011589878- Wireless Sensor Networks for Data Analysis
- Retinal Imaging and Analysis
- Medical Image Segmentation Techniques
- Infrared Thermography in Medicine
- Education, Psychology, and Social Research
- Non-Invasive Vital Sign Monitoring
- Osteoarthritis Treatment and Mechanisms
- Sensor Technology and Measurement Systems
- Glaucoma and retinal disorders
- ECG Monitoring and Analysis
- Advanced X-ray and CT Imaging
- Medical Imaging and Analysis
- Glycosylation and Glycoproteins Research
- Protein purification and stability
- Hops Chemistry and Applications
- Advanced Radiotherapy Techniques
- Fiscal Policy and Economic Growth
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Advanced MRI Techniques and Applications
- Advanced Scientific Research Methods
- Cardiovascular Health and Disease Prevention
- Advanced Chemical Sensor Technologies
- Image and Signal Denoising Methods
- Air Quality Monitoring and Forecasting
VSB - Technical University of Ostrava
2015-2024
UCB Pharma (Germany)
2023-2024
Prague University of Economics and Business
2005-2023
University of Ostrava
2018
Cybernetica (Estonia)
2018
Faculty (United Kingdom)
2018
University Hospital Ostrava
2013-2018
Technical University of Košice
2018
Nuclear Research Institute Rez (Czechia)
2009-2017
Forschungszentrum Jülich
2013-2017
Retinopathy of prematurity (ROP) represents a vasoproliferative disease, especially in newborns and infants, which can potentially affect damage the vision. Despite recent advances neonatal care medical guidelines, ROP still remains one leading causes worldwide childhood blindness. The paper presents unique dataset 6,004 retinal images 188 newborns, most whom are premature infants. is accompanied by anonymized patients' information from screening acquired at University Hospital Ostrava,...
Abstract The genetic code is universal, but recombinant protein expression in heterologous systems often hampered by divergent codon usage. Here, we demonstrate that reprogramming standardized multi‐parameter gene optimization software and de novo synthesis a suitable general strategy to improve expression. This study compares levels of 94 full‐length human wt sequence‐optimized genes coding for pharmaceutically important proteins such as kinases membrane E. coli . Fluorescence‐based...
Significance The QTY (glutamine, threonine, and tyrosine) code-designed detergent-free chemokine receptors may be useful in many applications. variants not only as reagents deorphanization studies but also for designing biologics to treat cancer autoimmune or infectious diseases. code allows membrane proteins systematically designed through simple, specific amino acid substitutions. is robust straightforward: It the simplest tool carry out protein design without sophisticated computer...
Retinopathy of prematurity (ROP) remains a significant cause childhood blindness despite advancements in neonatal care. Identifying the plus form ROP, characterized by dilated and tortuous blood vessels, is crucial for timely intervention. This study introduces an intelligent segmentation–classification system autonomous detection retinal vessels classification ROP form. Utilizing Clarity RetCam 3 images, our employs morphological image processing convolutional neural networks (CNNs)...
Slowpoke (Slo) potassium channels display extraordinarily high conductance, are synergistically activated by a positive transmembrane potential and intracellular Ca2+ concentrations important targets for insecticides antiparasitic drugs. However, it is unknown how these compounds modulate ion translocation whether there insect-specific binding pockets. Here, we report structures of Drosophila Slo in the Ca2+-bound Ca2+-free form complex with fungal neurotoxin verruculogen anthelmintic drug...
Vectorcardiography is an alternative form of ECG for measuring electrical activity the heart. It achieves higher sensitivity and provides cardiologist additional information that can contribute to early diagnosis. This study focused on proposal a methodology processing directly measured transformed VCG records by using Kors regression transformation. A total 16 features were extracted, while 12 showed relevant based statistical analysis method maximum relevance minimum redundancy. These...
Sucrose provides both sweetness and energy by binding to Venus flytrap domains (VFD) of the heterodimeric sweet taste receptor (T1R2/T1R3). In contrast, non-caloric sweeteners such as sucralose aspartame only bind one specific domain (VFD2) T1R2, resulting in high-intensity sweetness. this study, we investigate mechanism various steviol glycosides, artificial sweeteners, a negative allosteric modulator (lactisole) at four distinct sites: VFD2, VFD3, transmembrane 2 (TMD2), TMD3 through...
It was posited that functionalities of GPCRs require full-length sequences are negated by residue deletions. Here we report significantly truncated nfCCR5QTY and nfCXCR4QTY still bind native ligands. Receptor-ligand interactions were discovered from yeast 2-hybrid screening confirmed mating selection. Two (SZ218a, SZ190b) two (SZ158a, SZ146a) expressed in E. coli. Synthesized receptors exhibited α-helical structures bound respective ligands with reduced affinities. SZ190b SZ158a reconverted...
Standard solutions for handling a large amount of measured data obtained from intelligent buildings are currently available as software tools in IoT platforms. These optimize the operational and technical functions managing quality indoor environment factor real needs residents. The paper examines possibilities increasing accuracy CO₂ predictions Smart Home Care (SHC) using IBM SPSS to determine occupancy times monitored SHC room. processed were compared at daily, weekly monthly intervals...
Wearable devices are commonly used to monitor human movement since motor activity is a fundamental element in all phases of person's life. Patients with disorders need be monitored for prolonged period and the battery life can limit such goal. Here technique harvesting energy from body heat supply wearable investigated. A commercial flexible thermoelectric generator, equipped an accelerometer, placed on lower leg above ankle. The accelerometer serves detect diverse activities carried out by...
Wavelet transform (WT) is a commonly used method for noise suppression and feature extraction from biomedical images. The selection of WT system settings significantly affects the efficiency denoising procedure. This comparative study analyzed efficacy proposed on real 292 ultrasound images several areas interest. investigates performance different scaling functions two basic wavelet bases, Daubechies Symlets, their artificially corrupted by three kinds noise. To evaluate our extensive...
Prostate apoptosis response-4 (Par-4) was initially identified as a gene product up-regulated in prostate cancer cells undergoing apoptosis. In rat fibroblasts, coexpression of Par-4 and its interaction partner DAP-like kinase (Dlk, which is also known zipper-interacting protein [ZIPK]) induces relocation the from nucleus to actin filament system, followed by extensive myosin light chain (MLC) phosphorylation induction Our analyses show that synergistic proapoptotic effect Dlk/Par-4...