A5070293139- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Digital Imaging for Blood Diseases
- Cancer Mechanisms and Therapy
- Bone Metabolism and Diseases
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Plant Ecology and Taxonomy Studies
- vaccines and immunoinformatics approaches
- Plant Ecology and Soil Science
- Monoclonal and Polyclonal Antibodies Research
- Botany and Plant Ecology Studies
- FOXO transcription factor regulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Inflammatory mediators and NSAID effects
- Cell death mechanisms and regulation
- Natural product bioactivities and synthesis
Institut Pasteur de Tunis
2012-2018
Tunis El Manar University
2014-2016
Tuberculosis, a human infectious disease caused by Mycobacterium tuberculosis (M.tb), is still major cause of morbidity and mortality worldwide. The success M.tb as pathogen relies mainly on its ability to divert the host innate immune responses. One way which maintains persistent infection in "silent" granuloma inhibit inflammation induce an immunoregulatory phenotype macrophages (Ms). However, effectors governing switch Ms from pro-inflammatory M1 anti-inflammatory M2 remain be...
Early secreted antigenic target 6 kD a ( ESAT ‐6) and culture filtrate protein 10 CFP ‐10) are complex proteins by Mycobacterium tuberculosis that play major role in the pathogenesis of tuberculosis. However, studies focusing on biological functions ‐6 led to discordant results remains controversial. In present study, we aim address potential explanation for this discrepancy highlight physiological impact two conformational states ‐6. Analysis recombinant form native gel electrophoresis,...
Enhanced apoptosis of BCG-infected macrophages has been shown to induce stronger dendritic cell-mediated cross-priming T cells, leading higher protection against tuberculosis (TB). Uncovering host effectors underlying BCG-induced may then prove useful improve BCG efficacy through priming macrophage apoptosis. Her we report that BCG-mediated human relies on FOXO3 transcription factor activation. induced a significant THP1 (TDMs) and monocytes (MDMs)-derived when high moi was used, as by...