A5086830746- Chemical Synthesis and Analysis
- Trace Elements in Health
- Alzheimer's disease research and treatments
- Ferrocene Chemistry and Applications
- Mass Spectrometry Techniques and Applications
- Computational Drug Discovery Methods
- Drug Transport and Resistance Mechanisms
- Crystallography and molecular interactions
- Protein Structure and Dynamics
- Enzyme Structure and Function
- Coordination Chemistry and Organometallics
- Molecular Sensors and Ion Detection
- Prion Diseases and Protein Misfolding
- Peptidase Inhibition and Analysis
- RNA and protein synthesis mechanisms
- Redox biology and oxidative stress
- Metal complexes synthesis and properties
- Biochemical effects in animals
- Protein Hydrolysis and Bioactive Peptides
University of Debrecen
2013-2024
Abstract Copper(II) complexes of the N‐terminal peptide fragments tau protein have been studied by potentiometric and various spectroscopic techniques (UV‐vis, CD, ESR ESI‐MS). The octapeptide Tau(9‐16) (Ac−EVMEDHAG−NH 2 ) contains H14 residue native protein, while Tau(26‐33) (Ac−QGGYTMHQ−NH its mutants Tau(Q26K‐Q33K) (Ac−KGGYTMHK−NH Tau(Q26K‐Y29A‐Q33K) (Ac−KGGATMHK−NH include H32 residue. To compare binding ability in a single molecule decapeptide Ac−EDHAGTMHQD−NH (Tau(12‐16)(30‐34)) has...
The novel synthesized cysteine peptides form stable zinc(<sc>ii</sc>) and cadmium(<sc>ii</sc>) complexes; the specific sequence makes possible metal induced amide deprotonation.
The coordination features of the copper(<sc>ii</sc>) complexes with a Aβ(1–16)<sub>2</sub>dimeric model are reported for first time.
N-Terminally free but C-terminally amidated peptides Pen-SSACS-NH2 and CSSA-Pen-S-NH2 containing l-penicillamine (Pen) in sequence have been synthesized their nickel(ii), zinc(ii) cadmium(ii) complexes were studied by potentiometric spectroscopic measurements. This study is the first example of synthesis metal penicillamine a peptide constructed from natural amino acids. The data compared to those two cysteine counterparts, CSSACS-NH2. It was found that replacement l-cysteine with has...
Abstract Interactions between metal ions and proteins are considered reversible, such as the coordination of a ion to protein or enzyme, but irreversible processes like oxidative reactions, aggregation hydrolytic may occur. In presence Ni(II)‐ions selective hydrolysis peptides containing −SXH− −TXH− motif was observed. Since side chain histidine serves binding site for many native proteins, very often is present in sequence, study complex formation nickel(II) four were synthesised:...
Ratio of isomers 1 to nickel-ligand complexes formed in equimolar systems at pH 11 (left) and 7 (right) showing the influence an internal coordinating side chain.