A5070945140- Chemical Synthesis and Analysis
- Dental Health and Care Utilization
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Trace Elements in Health
- Molecular Sensors and Ion Detection
- Protein Structure and Dynamics
- Chemical and Physical Properties in Aqueous Solutions
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Crystallography and molecular interactions
- Dental Anxiety and Anesthesia Techniques
- Metal complexes synthesis and properties
- Analytical Chemistry and Chromatography
- Dental Research and COVID-19
- Advanced Proteomics Techniques and Applications
- Protein Hydrolysis and Bioactive Peptides
- Cholesterol and Lipid Metabolism
University of Debrecen
1998-2024
The Cd(II)-, Pb(II)-, Ni(II)- and Zn(II)-complexes of small terminally protected peptides containing CXXX, XXXC, XCCX, CXn C (n=1-3) sequences have been studied with potentiometric, UV/Vis CD spectroscopic techniques. cysteine thiolate group is the primary binding site for all metal ions, but presence a histidyl or aspartyl side chain in molecule contributes to stability complexes. For two-cysteine (S- ,S- ) coordinated species are formed physiological pH range increases...
Abstract Copper(II) complexes of the N‐terminal peptide fragments tau protein have been studied by potentiometric and various spectroscopic techniques (UV‐vis, CD, ESR ESI‐MS). The octapeptide Tau(9‐16) (Ac−EVMEDHAG−NH 2 ) contains H14 residue native protein, while Tau(26‐33) (Ac−QGGYTMHQ−NH its mutants Tau(Q26K‐Q33K) (Ac−KGGYTMHK−NH Tau(Q26K‐Y29A‐Q33K) (Ac−KGGATMHK−NH include H32 residue. To compare binding ability in a single molecule decapeptide Ac−EDHAGTMHQD−NH (Tau(12‐16)(30‐34)) has...
Nickel(II) and zinc(II) complexes of various peptide fragments tau protein have been investigated by potentiometric, UV-Vis, CD ESI-MS techniques. The peptides include the native fragment tau(9-16) (Ac-EVMEDHAG-NH2), Gln/Lys Tyr/Ala mutated (Ac-KGGYTMHK-NH2 Ac-KGGATMHK-NH2) tau(26-33). Similar to copper(II) a chimeric containing both His14 His32 residues in one molecule (Ac-EDHAGTMHQD-NH2) were also studied. metal binding ability R3 domain was studied using tau(326-333) (Ac-GNIHHKPG-NH2),...
For NH<sub>2</sub>-HAVAHHH-NH<sub>2</sub>peptide the coordination to internal histidines is preferred for copper(<sc>ii</sc>), while it opposite nickel(<sc>ii</sc>).
Abstract Introduction Dental care avoidance affects individuals' oral health status. There is limited literature examining the context of dental behavior. Aim The aim study to examine attitudes toward services among adults. Methods Overall, 16 patients participated in semi‐structured interviews. interviews were analyzed using inductive thematic analysis. Through independent reviews themes that comprise patients' experience, a consensus was established researchers. Results Ten major...