A5039828858- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Magnetism in coordination complexes
- Synthetic Organic Chemistry Methods
- Ferrocene Chemistry and Applications
- Lanthanide and Transition Metal Complexes
- Microbial Natural Products and Biosynthesis
- Catalytic Cross-Coupling Reactions
- Histone Deacetylase Inhibitors Research
- Lysosomal Storage Disorders Research
- Sphingolipid Metabolism and Signaling
- Crystallography and molecular interactions
- Marine Sponges and Natural Products
- Synthesis and Biological Activity
- biodegradable polymer synthesis and properties
- Catalytic Alkyne Reactions
- Chemical Synthesis and Analysis
- Carbon dioxide utilization in catalysis
- MXene and MAX Phase Materials
- Protein Degradation and Inhibitors
- Carbohydrate Chemistry and Synthesis
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
University of Bayreuth
2016-2020
Platinum(<sc>ii</sc>) complexes bearing two different,<italic>cis</italic>-oriented, N-heterocyclic carbene ligands are readily accessible for catalysis or as selective, pleiotropic anticancer agents.
New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages varying length to oxazole-bridged combretastatin A-4 analogous caps. While their antiproliferative and microtubule disrupting effect was most pronounced for derivatives with short spacers, HDAC inhibition strongest those longer spacers. These findings further supported computational methods such as structure-based docking experiments...
We report 15 new Cu(ii) complexes with tridentate NNO β-acylenamino ligands derived from 2-picolylamine and bearing up to three alkyl, alkoxy, alkoxycarbonyl, or (pseudo)halide substituents. The structures of nine were elucidated by single crystal X-ray diffraction analysis. Complexes an unsubstituted pyridine ring crystallised a square pyramidal coordination sphere, whereas substitution the led planar sphere around metal centre. solution properties characterised UV-Vis spectroscopy cyclic...
A series of new organometallic PtII complexes the type [Pt(C^N)Cl(DMSO)] (C^N=N,N-dimethyl-1-(2-aryl)methanamine-κ2 C2,N; aryl=phenyl 2 a, biphenyl b, p-terphenyl c, naphthyl d, anthracenyl e, or pyrenyl f) have been synthesized to explore influence aromaticity on their anticancer activity. The best performers, b and are more active than cisplatin (CDDP) in epithelial ovarian carcinoma cells A2780, with d having a higher selectivity factor CDDP all tested cell lines. In addition, compounds...
Ten novel N-heterocyclic carbene gold(I) complexes derived from lepidiline A (1,3-dibenzyl-4,5-dimethylimidazolium chloride) are reported here with full characterisation and biological testing. (1,3-Dibenzyl-4,5-diphenylimidazol-2-ylidene)gold(I) chloride (NHC*-AuCl) (1) was modified by substituting the for following: cyanide (2), dithiocarbamates (3–5), p-mercaptobenzoate derivatives (12–14) N-acetyl-l-cysteine (15–17). All were synthesised in good yields of 57–78%. Complexes 2, 12, 13, 14...
Eleven complexes of [(1,3-dialkylbenzimidazol-2-ylidene)LnCl3-n]Pt(n-1)+, with Ln = DMSO (8), Ph3P (9), (Ph3P)2 (10), and alkyl Me (a), Et (b), Bu (c), octyl (d), were synthesised tested for cellular accumulation, cytotoxicity, interference the tumour cell cycle, interaction DNA. The delocalised lipophilic cationic bisphosphane 10 on average found to be more cytotoxic in MTT assays against a panel seven cancer lines than neutral monophosphane 8 9. uptake 10, at least into HCT116 colon...
Abstract The synthesis of bio‐based and biodegradable plastics is a hot topic in research due to growing environmental problems caused by omnipresent plastics. As result, polylactide, which has been known for years, seen tremendous increase industrial production. Nevertheless, the manufacturing process using toxic catalyst Sn(Oct) 2 very critical. an alternative, five zinc acetate complexes have synthesized with Schiff base‐like ligands that exhibit high activity ring‐opening polymerization...
A series of ferrocene‐substituted derivatives ( 2a , 2b 2c 2d 2e 2f 2g ) the known drug 3,3′‐diindolylmethane DIM were prepared and tested for their in vitro antitumor activity. The (featuring indole moiety), 2‐methylindole moiety) 5‐nitroindole growth‐inhibiting at lower concentrations than various tumor cells including pancreas cancer (BcPC‐3), three DIM‐resistant cell lines (518 A2, KB‐V1/Vbl, HT‐29), triple‐negative breast (MDA‐MB‐231) prostate (PC‐3). Derivatives most active compounds...
The luminescent chalcone gold(I) conjugates [Au(PPh3)(AN3E)]PF6(1) and [Au(SIMes)(AN3E)]PF6 (2) (AN3E = (E)-3-(9-anthracenyl)-1-(4-pyridyl)propenone; SIMes N,N'-dimesitylimidazolidin-2-ylidene; Mes 2,4,6-trimethylphenyl)) were prepared characterized; complex 1 was also characterized by X-ray crystallography. In MTT assays against a panel of three human colon, melanoma breast cancer cell lines both complexes antiproliferative with low micromolar IC50 values. It is noteworthy that HCT116p53-/-...
PhICl<sub>2</sub> oxidises <italic>cis</italic>-/<italic>trans</italic>-[Pt<sup>II</sup>Cl<sub>2</sub>(NHC)<sub>2</sub>] complexes to stable, cancer-selective, cytotoxic <italic>cis</italic>-/<italic>trans</italic>-[Pt<sup>IV</sup>Cl<sub>4</sub>(NHC)<sub>2</sub>] while H<sub>2</sub>O<sub>2</sub> or NaOCl give [Pt<sup>IV</sup>Cl<sub>4−n</sub>(OH)<sub>n</sub>(NHC)<sub>2</sub>] that decompose.
<italic>cis</italic>-[Bis(1,3-dibenzylimidazol-2-ylidene)Pt<sup>II</sup>Cl(L)] complexes target mitochondria regardless of charge and size ligands L, yet show different anticancer effects.
New osmium(<sc>ii</sc>) complexes with an uncoordinated ester group for functionalization that are able to decrease the levels of intracellular ROS.