A5101495017- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Hepatitis C virus research
- Metal complexes synthesis and properties
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Photodynamic Therapy Research Studies
- Liver Disease Diagnosis and Treatment
- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Luminescence and Fluorescent Materials
- Ferrocene Chemistry and Applications
- Systemic Lupus Erythematosus Research
- Dendrimers and Hyperbranched Polymers
- Lanthanide and Transition Metal Complexes
- Sports and Physical Education Studies
- Advanced Nanomaterials in Catalysis
- Magnetism in coordination complexes
- Salivary Gland Disorders and Functions
- Renin-Angiotensin System Studies
- Heat Transfer and Optimization
- Genetic Associations and Epidemiology
- ATP Synthase and ATPases Research
- Physical Education and Pedagogy
- Autophagy in Disease and Therapy
Universidad de Murcia
2018-2024
Universidad de Valladolid
2020-2024
Instituto Murciano de Investigación Biosanitaria
2020-2022
Biomedical Research Institute
2018-2020
Hospital General Universitario De Valencia
2001-2019
Rede de Química e Tecnologia
2019
Universidad de Las Palmas de Gran Canaria
2002
Photodynamic therapy (PDT) represents a promising approach for cancer treatment. However, the oxygen dependency of PDT to generate reactive species (ROS) hampers its therapeutic efficacy, especially against hypoxic solid tumors. In addition, some photosensitizers (PSs) have dark toxicity and are only activatable with short wavelengths such as blue or UV-light, which suffer from poor tissue penetration. Herein, we developed novel hypoxia-active PS operability in near-infrared (NIR) region...
Despite the potential of photodynamic therapy (PDT) in cancer treatment, development efficient and photostable photosensitizing molecules that operate at long wavelengths light has become a major hurdle. Here, we report for first time an Ir(III)-phthalocyanine conjugate (
Photodynamic therapy (PDT) for cancer treatment has drawn increased attention over the last decades. Herein, we introduce a novel family of low-molecular-weight coumarins as potential PDT anticancer tools. Through systematic study with library 15 compounds, have established detailed structure–activity relationship rationale, which allowed selection three lead compounds exhibiting effective in vitro activities upon visible-light irradiation both normoxia and hypoxia (phototherapeutic indexes...
Photodynamic therapy holds great promise as a non-invasive anticancer tool against drug-resistant cancers. However, highly effective, non-toxic, and reliable photosensitizers with operability under hypoxic conditions remain to be developed. Herein, we took the advantageous properties of COUPY fluorophores cyclometalated Ir(III) complexes develop novel PDT agents based on Ir(III)-COUPY conjugates aim exploring structure–activity relationships. The structural modifications carried out within...
Translation is the most energy-consuming activity within cells. Due to metabolic demands and high proliferation, cancer cells require elevated rates of protein synthesis, thus providing a therapeutic window selectively eliminate them. Among potential anticancer agents, metallodrugs have arisen as an important class chemotherapeutics due variety possible molecular architectures multiple coordination redox states these compounds can achieve. Inorganic medicinal drug discovery has experimented...
Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some the "Achiles' heels" photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with aim developing novel nanoPDT agents. The synthesis coumarin-loaded NCs involved nanoemulsification suitable prepolymer in presence without needing external surfactants, and resulting small...
Abstract Oncosis (from Greek ónkos , meaning “swelling”) is a non-apoptotic cell death process related to energy depletion. In contrast apoptosis, which the main form of induced by anticancer drugs, oncosis has been relatively less explored but holds potential overcome drug resistance phenomena. this study, we report novel rationally designed mitochondria-targeted iridium(III) complex ( OncoIr3 ) with advantageous properties as bioimaging agent. exhibited potent activity in vitro against...
Despite the potential of photodynamic therapy (PDT), this oxygen-dependent oncological treatment is greatly restricted in clinic by well-known hypoxic feature solid tumors. Here we provide new insights...
Hepatitis C virus (HCV) is a major cause of liver disease worldwide and potential substantial morbidity mortality in the future. HCV characterized by high level genetic heterogeneity. Although homologous recombination has been demonstrated many members family Flaviviridae, to which belongs, there are only few studies reporting on natural populations HCV, suggesting that these events rare vivo. Furthermore, have focused between different genotypes/subtypes but no reports extent intra-genotype...
Ruthenium(II) complexes containing diimine ligands have contributed to the development of agents for photoactivated chemotherapy. Several approaches been used obtain photolabile Ru(II) complexes. The two most explored use monodentate and incorporation steric effects between bidentate Ru(II). However, introduction electronic in has less explored. Herein, we report a systematic experimental, theoretical, photocytotoxicity study novel series Ru1–Ru5 general formula [Ru(phen)2(N∧N′)]2+, where...
Background. We compared the prognostic value of liver biopsy (LB) and FIB-4 index in patients with human immunodeficiency virus (HIV)/hepatitis C (HCV) coinfection.
In the process of synthesis a new drug, as important drug itself is formulation used, because same compound can present very different efficacy depending on how it administered. this work, we demonstrate antitumor capacity octahedral organoruthenium complex, [Ru(ppy-CHO)(phen)2][PF6] affected by its encapsulation in types mesoporous silica nanoparticles. The interactions between Ru complex and matrix these are at two pHs (7.4 5.4, mimicking physiological endolysosomal acidic conditions,...
Half-sandwich ruthenium(ii) complexes [(η6-p-cymene)Ru(C^N)-(X)]0/+ (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy 1-ppz with non-coordinated CHO group as handle for further functionalization have been synthesized to achieve selective cytotoxicity cancer cells, the more potent compounds acting proteosynthesis inhibitors; this is new mode of action half-sandwich metal complexes.
The specific recognition of AT-rich DNA sequences opens up the door to promising diagnostic and/or therapeutic strategies against gene-related diseases. Here, we demonstrate that amphiphilic PtII complexes type [Pt(dmba)(N∧N)]NO3 (dmba = N,N-dimethylbenzylamine-κN, κC; N∧N dpq (3), dppz (4), and dppn (5)) recognize oligonucleotides over other types DNA, RNA, model proteins. crystal structure 4 shows presence significant π-stacking interactions a distorted coordination sphere d8 atom. Complex...
Polyurethane–polyurea hybrid nanocapsules can be used as efficient delivery systems of anticancer Ir( iii ) metallodrugs.
Summary. Hepatitis C virus (HCV) is a major health problem worldwide, infecting an estimated 170 million people. The high genetic variability of HCV contributes to the chronicity hepatitis C. Here, we report results from large‐scale sequence analysis 67 patients infected with genotype 1, 23 subtype 1a and 44 1b. Two regions genome were analysed in samples prior combined therapy alpha interferon plus ribavirin, one compressing hypervariable (HVR1, HVR2 HVR3) E2 glycoprotein another including...
Ru(<sc>ii</sc>) complexes exhibit phototherapeutic indexes higher than 750 in cancer HeLa cells with low nanomolar IC<sub>50</sub> values under doses of non-harmful green light and are active normoxia hypoxia conditions.
Cancer and antibiotic resistance are two global health threats that usually hamper clinical chemotherapeutic efficacy. Particularly for lung cancer, bacterial infections frequently arise thereby complicating the course of cancer treatment. In this sense, three new neutral luminescent cycloplatinated(II) photosensitizers type [Pt(dmba)(L)] (dmba = N,N-dimethylbenzylamine-κN,κC; L 2-(benzo[d]oxazol-2-yl)-phenolato-κN,κO 1, 2-(benzo[d]thiazol-2-yl)-phenolato-κN,κO 2,...
The luminescent chalcone gold(I) conjugates [Au(PPh3)(AN3E)]PF6(1) and [Au(SIMes)(AN3E)]PF6 (2) (AN3E = (E)-3-(9-anthracenyl)-1-(4-pyridyl)propenone; SIMes N,N'-dimesitylimidazolidin-2-ylidene; Mes 2,4,6-trimethylphenyl)) were prepared characterized; complex 1 was also characterized by X-ray crystallography. In MTT assays against a panel of three human colon, melanoma breast cancer cell lines both complexes antiproliferative with low micromolar IC50 values. It is noteworthy that HCT116p53-/-...
Hepatitis C virus (HCV) infection affects about 3 % of the human population. Phylogenetic analyses have grouped its variants into six major genotypes, which a star-like distribution and several minor subtypes. The most abundant genotype in Europe is so-called 1, with two prevalent subtypes, 1a 1b. In order to explain higher prevalence subtype 1b over 1a, large-scale sequence analysis (100 clones) has been carried out 25 patients both subtypes regions HCV genome: one comprising hypervariable...
Little is known about the potential effects of insertions and deletions (indels) on evolutionary dynamics hepatitis C virus (HCV). In fact, consequences indels antiviral treatment response are a field investigation completely unexplored. Here, an extensive sequencing project was undertaken by cloning serum samples from 25 patients infected with HCV subtype 1a 48 1b. For 23 patients, obtained after alpha interferon plus ribavirin were also available. Two genome fragments containing...
Novel Os(<sc>ii</sc>) arene complexes with a deprotonated ppy or ppy-CHO C^N ligand have been synthesized to selectively act on cancer cells as proteosynthesis inhibitors<italic>in vitro</italic>and exert antitumor activity<italic>in vivo</italic>in<italic>C. elegans</italic>models.
We present an analysis of the selective forces acting on two hepatitis C virus genome regions previously postulated to be involved in viral response combined antiviral therapy. One includes three hypervariable envelope E2 glycoprotein, and other encompasses PKR binding domain V3 NS5A region. used a cohort 22 non-responder patients therapy (interferon alpha-2a plus ribavirin) for which samples were obtained before initiation after 6 or/and 12 months treatment. A range 25-100 clones per...