Mariia Zakharova

ORCID: 0000-0003-0206-0966
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About
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Research Areas
  • 3D Printing in Biomedical Research
  • Neuroscience and Neural Engineering
  • Congenital heart defects research
  • Systemic Lupus Erythematosus Research
  • Zebrafish Biomedical Research Applications
  • Barrier Structure and Function Studies
  • Rheumatoid Arthritis Research and Therapies
  • Orthopaedic implants and arthroplasty
  • Advanced Sensor and Energy Harvesting Materials
  • Proteoglycans and glycosaminoglycans research
  • Muscle activation and electromyography studies
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Knee injuries and reconstruction techniques
  • Microfluidic and Capillary Electrophoresis Applications
  • Silk-based biomaterials and applications
  • Fibromyalgia and Chronic Fatigue Syndrome Research
  • Cellular Mechanics and Interactions
  • Vector-borne infectious diseases
  • Electrospun Nanofibers in Biomedical Applications
  • Viral Infections and Immunology Research
  • Lubricants and Their Additives
  • Toxin Mechanisms and Immunotoxins
  • Axon Guidance and Neuronal Signaling
  • Osteoarthritis Treatment and Mechanisms
  • Fish Ecology and Management Studies

Max Planck University of Twente Center for Complex Fluid Dynamics
2020-2024

University of Twente
2020-2024

Institute of Nanotechnology
2020-2021

Max Planck Institute for Dynamics of Complex Technical Systems
2021

Chan Heart Rhythm Institute
2020

University of Edinburgh
2020

Sensors (United States)
2019

Russian Academy of Sciences
2009

Organ-on-chip devices are intensively studied in academia and industry due to their high potential pharmaceutical biomedical applications. However, most of the existing organ-on-chip models focus on proof concept individual functional units without possibility testing multiple experimental stimuli parallel. Here we developed a polydimethylsiloxane (PDMS) multiplexed chip with eight parallel channels branching from common access port through which all can be addressed simultaneously need for...

10.1039/d0lc00399a article EN cc-by Lab on a Chip 2020-01-01

Transepithelial/transendothelial electrical resistance (TEER) measurements can be applied in organ-on-chips (OoCs) to estimate the barrier properties of a tissue or cell layer continuous, non-invasive, and label-free manner. Assessing integrity vitro models is valuable for studying developing targeting drugs. Several systems measuring TEER have been shown, but each them having their own drawbacks. This article presents cleanroom-free fabrication method integration platinum electrodes...

10.1039/d0lc01289k article EN cc-by-nc Lab on a Chip 2021-01-01

Abstract Traditional Transwell inserts with track‐etched 10 μm thick polymer membranes have been intensively used for studying cellular barriers. However, their thickness hampers direct cell‐cell interaction between the adjacent cells which has shown to critically influence barrier formation. Therefore, here effect of reduced distance by using fivefold thinner (2 μm) optically transparent polydimethylsiloxane (PDMS) is studied and compared polycarbonate (PC) membranes. The authors validate...

10.1002/admt.202100138 article EN Advanced Materials Technologies 2021-08-21

Not only the flow of liquid through vasculature, but also external fluid flows can affect organization and maturation vessels.

10.1039/d4lc00311j article EN cc-by Lab on a Chip 2024-01-01

The impact of fluid flow shear stresses, generated by the movement blood through vasculature, on organization and maturation vessels is widely recognized. Nevertheless, it remains uncertain whether external flows outside vasculature in surrounding tissue can similarly play a role governing these processes. In this research, we introduce an innovative technique called superfusion-induced vascular steering (SIVS). SIVS involves controlled imposition patterns onto vascularized chick...

10.1101/2024.01.11.575208 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-01-14
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