A5092720998- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Neurogenesis and neuroplasticity mechanisms
- Graphene and Nanomaterials Applications
- EEG and Brain-Computer Interfaces
- Phagocytosis and Immune Regulation
Imperial College London
2023
UK Dementia Research Institute
2023
University of Edinburgh
2023
Synapse loss correlates with cognitive decline in Alzheimer's disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence any glial involvement removal AD remains to be established. Here we observe astrocytes and brains contain greater amounts of synaptic protein compared non-disease controls, that proximity amyloid-β plaques the APOE4 risk gene exacerbate this effect. In culture, primary phagocytose patient-derived synapses more...
Summary Synapse loss correlates with cognitive decline in Alzheimer’s disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence any glial involvement removal AD remains to be established. Here we observe astrocytes and brains contain greater amounts of synaptic protein compared non-disease controls, that proximity amyloid-β plaques the APOE4 risk gene exacerbate this effect. In culture, primary phagocytose patient-derived...
Abstract Background Large‐scale efforts to reverse or stop the progression of Alzheimer’s disease (AD) and associated cognitive decline have failed produce viable treatment options, highlighting need for new interventional strategies. A significant feature AD is aberrant changes in brain network activity dynamics, closely coupled with functional impairment pathophysiology deep structures, such as hippocampus. In this study, we are investigating effects multi‐session, non‐invasive temporal...