A5031083278- RNA modifications and cancer
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Vascular Procedures and Complications
- Helicobacter pylori-related gastroenterology studies
- Central Venous Catheters and Hemodialysis
- Cancer Mechanisms and Therapy
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Cardiac Arrhythmias and Treatments
- Liver Disease Diagnosis and Treatment
- Abdominal vascular conditions and treatments
- Cancer Cells and Metastasis
- Machine Learning in Bioinformatics
- Liver Disease and Transplantation
- Cancer therapeutics and mechanisms
- Cardiomyopathy and Myosin Studies
- Glycosylation and Glycoproteins Research
- Mechanisms of cancer metastasis
- Hedgehog Signaling Pathway Studies
- Synthesis and biological activity
Beijing University of Technology
2010-2024
The University of Texas Medical Branch at Galveston
2018-2024
Sun Yat-sen University
2009-2024
Sun Yat-sen Memorial Hospital
2009-2024
Boston Children's Hospital
2020-2023
Harvard University
2020-2023
Ganzhou People's Hospital
2021-2023
Guangdong Provincial People's Hospital
2022-2023
Corteva (United States)
2023
Second Affiliated Hospital of Xi'an Jiaotong University
2022
AIM:To make a retrospective analysis of endoscopy findings and clinicopathologic characteristics colonic schistosomiasis in order to further improve our understanding the disease decrease its misdiagnosis. METHODS:Endoscopy 46 intestinal patients were retrospectively analyzed.All underwent colonoscopy all biopsy specimens stained with hematoxylin eosin observed under light microscope. RESULTS:Of patients, 1 was diagnosed as acute schistosomal colitis, 16 chronic colitis 29 active according...
Abstract High-quality reference genome assemblies, representative of global heterotic patterns, offer an ideal platform to accurately characterize and utilize genetic variation in the primary gene pool hybrid crops. Here we report three platinum grade de-novo , near gap-free, chromosome-level assemblies from active breeding germplasm pearl millet with a high degree contiguity, completeness, accuracy. An improved Tift (Tift23D 2 B 1 -P1-P5) assembly has contig N50 ~ 7,000-fold (126 Mb)...
Carcinoma progression is associated with the loss of epithelial features and acquisition a mesenchymal phenotype, process known as epithelial‑mesenchymal transition (EMT). Resveratrol, natural polyphenolic compound found in grapes, berries peanuts, has wide range pharmacological properties, including anti‑tumor metastasis properties. The underlying mechanism through which resveratrol inhibits prostate cancer (PCa) not yet fully understood; however, it thought to be disruption EMT. In present...
RNA splicing is an important processing step required by multiexon protein-coding mRNAs and some noncoding RNAs. Precise for maintaining gene cell function; however, mis-spliced transcripts can lead to loss- or gain-of-function effects in human diseases. Mis-spliced RNAs induced mutations the dysregulation of regulators may result frameshifts, nonsense-mediated decay (NMD), inclusion/exclusion exons. Genetic animal models have characterised multiple factors cardiac development function....
Cisplatin has been hypothesized to induce nephrotoxicity through triggering the apoptosis of tubular cells; however, drug remains widely administered for treatment tumors. Recently, mesenchymal stem cells (MSCs) have demonstrated protect kidney from adverse effects induced by cisplatin. The aim present study was investigate mechanisms underlying protective human adipose‑derived MSCs (AD‑MSCs) on function and cells. Sprague‑Dawley rats were divided into three groups, which included healthy...
beta-Hydroxyisovalerylshikonin (beta-HIVS), which was isolated from the plant, Lithospermium radix, inhibited growth of various lines cancer cells derived human solid tumors at low concentrations between 10(-8) and 10(-6) M. When HL-60 were treated with M beta-HIVS for 3 h, characteristic features apoptosis, such as DNA fragmentation, nuclear activation caspase-3-like activity, observed. The most effect remarkable morphological changes induced upon treatment beta-HIVS, visualized on staining...
Recent studies report that microRNA‐519a (miR‐519a) is a novel oncomir, which facilitates the onset and progression of human cancers. However, clinical significance miR‐519a its functional role underlying mechanisms in hepatocellular carcinoma (HCC) are poorly investigated. In present study, elevated expression was observed HCC tissues compared with adjacent non‐tumor tissues. The increased level significantly correlated adverse features including hepatitis B virus (HBV) infection, large...
Alternative splicing (AS) contributes to the diversity of proteome by producing multiple isoforms from a single gene. Although short-read RNA-sequencing methods have been gold standard for determining AS patterns genes, they difficulty in defining full-length mRNA assembled using different exon combinations. Tropomyosin 1 (TPM1) is an actin-binding protein required cytoskeletal functions non-muscle cells and contraction muscle cells. Tpm1 undergoes regulation generate versus TPM1 with...
RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it unclear whether RBFOX2 other roles RNA processing that can influence gene expression muscle cells, contributing disease. Here, we employ both 3ʹ-end and nanopore cDNA sequencing reveal previously unrecognized for maintaining polyadenylation (APA) signatures myoblasts. RBFOX2-mediated APA modulates mRNA levels and/or isoform of collection genes, including contractile mitochondrial...
Background: Our previous study identified a novel microRNA, miR-4673, which is upregulated in A549 cells exposed to paclitaxel (PTX). In this study, we investigated the role of miR-4673 PTX-induced cytotoxicity. Methods: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, apoptosis 5,5’,6,6’-Tetrachloro-1,1’,3,3’-tetraethyl-imidacarbocyanine iodide (JC-1) staining and 2’,7’-Dichlorofluorescein (DCFH) were used evaluate cell viability, apoptosis, mitochondrial membrane...
Background: Recent researches and relevant patents have been reported to prove the significant value of Caveolin-1 (Cav-1) in cancer diagnosis treatment. Objective: Our study aimed role Cav-1 gastric progression investigate relationship between Cav-1/E-cadherin expression clinical status cancer. Method: Immunohistochemistry was applied detect E-cadherin a tissue microarray. Real-time PCR used further mRNA tumor-derived peritumoral tissues different cell lines. The analyzed by Western Blot...
Sweroside is an active ingredient of iridoid glycoside isolated from the flower buds Lonicera japonica THUNB. A quantitative HPLC-UV method was developed for monitoring sweroside in rat plasma, urine, feces and bile. The successfully applied a basic pharmacokinetic study. obtained data pharmacokinetics were to evaluate oral bioavailabilities ingredients purified herbal extracts (IGEs-1). absolute bioavailability estimated Fsweroside 0.31% FIGEs-1 0.67%. majority excreted revealed one reason...