A5004108516- Advanced Radiotherapy Techniques
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Radiation Therapy and Dosimetry
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Radiation Detection and Scintillator Technologies
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Radiopharmaceutical Chemistry and Applications
- Radiation Effects and Dosimetry
- Lymphoma Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging and Analysis
- Ultrasound and Hyperthermia Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Lung Cancer Treatments and Mutations
- Nuclear Physics and Applications
- Statistical Methods in Clinical Trials
- Glioma Diagnosis and Treatment
- Atomic and Subatomic Physics Research
- Head and Neck Cancer Studies
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2015-2025
Fondazione Ricerca Molinette
2022
University of Turin
2006-2016
Piedmont Reference Center for Epidemiology and Cancer Prevention
2016
Azienda Ospedaliero Universitaria San Giovanni Battista
2004-2011
Ospedale degli Infermi
1992-1994
The Gafchromic™ EBT was recently introduced in film dosimetry for external beam therapy (EBT). high spatial resolution, weak energy dependence, and near‐tissue equivalence of films make them suitable measurement dose distributions radiotherapy, especially intensity‐modulated radiation (IMRT). Starting with a sensitometric curve uncertainty relative to the flatbed scanner, goal this study find an efficient method correcting light scattering, compare distribution supplied by obtained 2D...
The objective of this study was to assess the utility CT-MRI image fusion software and compare both prostate volume localization with CT MRI studies. We evaluated differences in clinical volumes patients undergoing three-dimensional conformal radiation therapy for localized cancer. After several tests performed ensure quality software, eight suffering from adenocarcinoma were submitted studies treatment position within an immobilization device before start radiotherapy. target (CTV)...
The aim was to retrospectively investigate correlations between potential predictive parameters and the occurrence of radiation-induced lung injury in patients with primary or secondary tumours treated stereotactic body radiation therapy (SBRT). Sixty (63 tumours) underwent SBRT, a dose 45 Gy 3 fractions over 5 days 26 single fraction. following were tested for correlation Radiation Therapy Oncology Group (RTOG) toxicity score: planning target volume (PTV), tumour location, vs. metastatic...
Growth hormone-releasing hormone (GHRH) antagonists exert antitumor functions in different experimental cancers. However, their role combination with radiotherapy non-small cell lung cancer (NSCLC) remains unknown. Therefore, we investigated the radiosensitizing effect of GHRH NSCLC. A549 and H522 NSCLC lines were exposed to ionizing radiation (IR) MIA-602 MIA-690, either individually or combination. Cell viability proliferation evaluated by MTT, BrdU, flow cytofluorimetry, clonogenic...
Purpose: Patient-specific quality assurance in volumetric modulated arc therapy (VMAT) brain stereotactic radiosurgery raises specific issues on dosimetric procedures, mainly represented by the small radiation fields associated with lack of lateral electronic equilibrium, need detectors and high dose delivered (up to 30 Gy). GafchromicTM EBT2 EBT3 films may be considered dosimeter choice, authors here provide some additional data about uniformity correction for this new generation...
To investigate whether the incorporation of 18FDG-PET into automatic treatment planning process may be able to decrease dose active bone marrow (BM) for locally advanced anal cancer patients undergoing concurrent chemo-radiation (CHT-RT).Ten with were selected. Bone within pelvis was outlined as whole outer contour pelvic bones or employing identify BM osseous structures. Four solutions employed different optimization approaches toward marrow. Plan A used iliac crests per RTOG 05-29 trial;...
To investigate the efficacy of a schedule low-dose radiotherapy (LDRT) with 4 Gy (2 x 2) in cohort unselected MALT or MZL patients.We retrospectively collected all patients receiving LDRT, either for cure palliation, stage I-IV histologically proven between 2016 and 2020. Response to LDRT was evaluated Lugano criteria. Local control (LC), distant relapse-free survival (DRFS), progression-free (PFS) overall (OS) were stratified treatment intent (curative vs palliative) estimated by...
We investigated the role of selective avoidance haematopoietically active pelvic bone marrow (BM), with a targeted intensity-modulated radiotherapy (IMRT) approach, to reduce acute hematologic toxicity (HT) in anal cancer patients undergoing concurrent chemo-radiation. designed one-armed two-stage Simon’s design study test hypothesis that BM-sparing IMRT would improve by 20% rate G0–G2 (vs. G3–G4) HT, from 42% RTOG 0529 historical data 62% (α = 0.05; β 0.20). A minimum 21/39 (54%)...
Aims and background Brachytherapy for prostate cancer by means of permanently implanted 125 I sources is a well established procedure. An increasing number patients all over the world are treated with this modality. When technique was introduced at our institution, radiation protection issues relative to were investigated in order comply international recommendations national regulations. Particular attention paid need patient shielding after discharge from hospital. Methods The effective...
The aim of this study was to evaluate various approaches for assessing patient organ doses resulting from radiotherapy cone-beam CT (CBCT), by the use thermoluminescent dosimeter (TLD) measurements in anthropomorphic phantoms, a Monte Carlo based dose calculation software, and different indicators as presently defined.Dose evaluations were performed on CBCT Elekta XVI (Elekta, Crawley, UK) protocols anatomical regions. first part focuses using pcxmc software (pcxmc 2.0, STUK, Helsinki,...