A5082643877- Cellular transport and secretion
- Neonatal Health and Biochemistry
- Advanced Memory and Neural Computing
- Retinal Development and Disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Receptor Mechanisms and Signaling
- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Nitric Oxide and Endothelin Effects
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Retinal Diseases and Treatments
- Protein Tyrosine Phosphatases
- Adenosine and Purinergic Signaling
Johns Hopkins University
2015-2023
Loss of a sensory modality leads to widespread changes in synaptic function across cortices, which are thought be the basis for cross-modal adaptation. Previous studies suggest that experience-dependent regulation spared cortices may mediated by cortical circuits. Here, we report loss vision, form dark exposure (DE) 1 week, produces laminar-specific excitatory and inhibitory circuits primary auditory cortex (A1) adult mice promote feedforward (FF) processing also strengthens intracortical...
In neurons, many membrane proteins, synthesized in cell bodies, must be efficiently delivered to axons influence neuronal connectivity, synaptic communication, and repair. Previously, we found that axonal targeting of TrkA neurotrophin receptors sympathetic neurons occurs via an atypical transport mechanism called transcytosis, which relies on interactions with PTP1B, a protein tyrosine phosphatase. Here, generated
NR2E3 is an orphan nuclear receptor whose loss-of-function causes abnormal retinal photoreceptor development and degeneration. However, despite that many receptors are regulated by binding of small molecule ligands, biological ligands regulating have not been identified. Identification endogenous ligand might reveal a previously unrecognized component contributing to maintenance. Here we report biliverdin, conserved green pigment from heme catabolism, regulates necessary for zebrafish...
The orphan nuclear receptor NR2E3 (also known as PNR) is a transcription factor important for retinal photoreceptor development and maintenance. Mutations in cause diseases vision loss human. However, despite the importance of ligand‐binding regulation receptors, endogenous ligand not yet known. Identification will provide better understanding on how are regulated. Here we report that biliverdin an biliverdin‐NR2E3 complex forms light‐sensitive system. Using gel‐filtration...
Summary In neurons, many membrane proteins, synthesized in cell bodies, must be efficiently delivered to axons influence neuronal connectivity, synaptic communication, and repair. Previously, we found that axonal targeting of TrkA neurotrophin receptors sympathetic neurons occurs via an atypical transport mechanism called transcytosis, which relies on interactions with PTP1B, a protein tyrosine phosphatase. Here, generated R685A mice, where receptor signaling is preserved, but its...