A5010611247- Heart Rate Variability and Autonomic Control
- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac Arrest and Resuscitation
- Cardiac, Anesthesia and Surgical Outcomes
- Pain Mechanisms and Treatments
- High Altitude and Hypoxia
- Cardiovascular and exercise physiology
- Veterinary Pharmacology and Anesthesia
- Treatment of Major Depression
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intensive Care Unit Cognitive Disorders
- Medical Malpractice and Liability Issues
- Thermoregulation and physiological responses
- Airway Management and Intubation Techniques
- Blood Pressure and Hypertension Studies
- Radiation Therapy and Dosimetry
- Heart Failure Treatment and Management
- Family and Patient Care in Intensive Care Units
- Innovations in Medical Education
- Cardiovascular Issues in Pregnancy
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Enhanced Recovery After Surgery
- Surgical Simulation and Training
Worldwide Clinical Trials (United States)
2024-2025
Institute for Exercise and Environmental Medicine
2016-2024
The University of Texas Southwestern Medical Center
2013-2024
Presbyterian Hospital
2016-2024
Institut Mines-Télécom Business School
2020
Southwestern Medical Center
2020
Pain Management Institute
2020
Texas Health Dallas
2016-2019
Matsumoto Dental University
2016
Northern Arizona University
2016
Background: Chronotropic incompetence is common in heart failure with preserved ejection fraction (HFpEF) and associated impaired aerobic capacity. We investigated the integrity of cardiac β–receptor responsiveness, an important mechanism involved exertional increases HR, HFpEF control subjects. Methods: Thirteen carefully screened patients 13 senior controls underwent exercise testing graded isoproterenol infusion to quantify β–receptor–mediated HR responses. To limit autonomic neural...
Hadler, Rachel A. MD; Curry, Saundra E. Hendrix, Joseph M. MD, FASA; Michaelis, Maria Minzter, Beth FIPP; Pelletier, Pete West, James MA; Souter, Michael J. MBChB, FRCA; on behalf of the Committee Ethics American Society Anesthesiologists Author Information
The sympathetic response during the cold pressor test (CPT) has been reported to be greater in young blacks than whites, especially those with a family history of hypertension. Because blood pressure (BP) increases age, we evaluated whether elderly have activation CPT age-matched whites. BP, heart rate, cardiac output, and muscle nerve activity were measured supine baseline, 2-minute CPT, 3-minute recovery 47 (68±7 [SD] years) volunteers (12 35 whites). Baseline or did not differ between...
In this randomized, crossover, placebo-controlled trial, we found that tolerance to simulated hemorrhage was lower after low-dose morphine administration. Such reductions in hemorrhagic were observed without differences MSNA burst frequency responses between and placebo trials. These data, the first be obtained conscious humans, demonstrate reduces tolerance. Thus, is not an ideal analgesic for a hemorrhaging individual prehospital setting.
Key points Low dose ketamine is a leading medication used to provide analgesia in pre‐hospital and hospital settings. increasingly off‐label treat conditions such as depression. In animals, stimulates the sympathetic nervous system increases blood pressure, but these physiological consequences have not been studied conscious humans. Our data suggest that low administration blunts pain perception reduces muscle nerve activity burst frequency, responses during cold pressor test healthy These...
Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths. Ketamine, fentanyl, morphine are recommended analgesics for use in the prehospital (i.e., field) setting to reduce pain. However, it unknown whether any these hemorrhagic tolerance humans. We tested hypothesis that fentanyl (75 µg) (5 mg), but not ketamine (20 would simulated hemorrhage conscious Each three was evaluated independently among different cohorts healthy adults randomized, crossover (within...
This study aimed to assess the efficacy of acute subanesthetic dosages xenon inhalation cause erythropoiesis and determine effect chronic dosing on hematological parameters athletic performance. To effects, seven subjects breathed three concentrations xenon: 30% fraction inspired (FiXe) for 20 min, 50% FiXe 5 70% 2 min. Erythropoietin (EPO) was measured at baseline, during, after inhalation. eight min 7 consecutive days, EPO, total blood, plasma volume were measured. Phase II involved...
Our knowledge about how low-dose (analgesic) fentanyl affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it unknown if influences human responses during painful stimuli in humans. Therefore, we tested the hypothesis that reduces perceived pain and subsequent sympathetic humans an experimental noxious stimulus. Twenty-three adults (10 females/13 males; 27 ± 7 yr; 26 3 kg·m −2 , means SD) completed this randomized, crossover, placebo-controlled...
Previous work demonstrates augmented muscle sympathetic nerve activity (MSNA) responses to the cold pressor test (CPT) in older women. Given its interindividual variability, however, influence of baseline MSNA on CPT reactivity adults remains unknown. Sixty volunteers (60-83y; 30 women) completed testing where (microneurography), blood pressure (BP), and heart rate (HR) were recorded during a 2-min (~4°C). Participant data terciled by (n=10/group); comparisons made between high men (HM)...
Key points Haemorrhage is the leading cause of battlefield and civilian trauma deaths. Given that a haemorrhagic injury on almost always associated with pain, it paramount administered pain medication does not disrupt physiological mechanisms are beneficial in defending against insult. Current guidelines from US Army's Committee Tactical Combat Casualty Care (CoTCCC) for selection medications to haemorrhaging soldier based upon limited scientific evidence, clear majority supporting studies...
Our knowledge about how low-dose (analgesic) morphine affects autonomic cardiovascular regulation is primarily limited to animal experiments. Notably, it unknown if human responses during painful stimuli in conscious humans. Therefore, we tested the hypothesis that reduces perceived pain and subsequent sympathetic humans an experimental noxious stimulus. Twenty-nine participants (14 females/15 males; 29 ± 6 yr; 26 4 kg·m
Hemorrhage is a leading cause of battlefield and civilian trauma deaths. Several pain medications, including fentanyl, are recommended for use in the prehospital (i.e., field setting) hemorrhaging solider. However, it unknown whether fentanyl impairs arterial blood pressure (BP) regulation, which would compromise hemorrhagic tolerance. Thus, purpose this study was to test hypothesis that an analgesic dose tolerance conscious humans. Twenty-eight volunteers (13 females) participated...
This study aimed to quantify the sedative effects, detection rates, and cardiovascular responses xenon. On 3 occasions, participants breathed xenon (FiXe 30% for 20 min; FiXe 50% 5 70% 2 min) in a nonblinded design. Sedation was monitored by board-certified anesthesiologist. During xenon, were also verbally instructed operate manual value with time-to-task failure being recorded. Beat-by-beat hemodynamics measured continuously ECG, photoplethysmography, transcranial Doppler. Over 48 h...
Addressing two unique aims, we observed that sublingual sufentanil administration does not impair tolerance or cardiovascular responses to lower-body negative pressure (LBNP)-induced progressive central hypovolemia. Second, despite pain perception being reduced, did attenuate mean blood a cold pressor test (CPT).