A5040809163- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Cardiovascular and exercise physiology
- Kidney Stones and Urolithiasis Treatments
- SARS-CoV-2 and COVID-19 Research
- Thermoregulation and physiological responses
- Pediatric Urology and Nephrology Studies
- Cardiovascular Health and Disease Prevention
- Rheumatoid Arthritis Research and Therapies
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Sports Performance and Training
- Exercise and Physiological Responses
- Obstructive Sleep Apnea Research
- Non-Invasive Vital Sign Monitoring
- Respiratory Support and Mechanisms
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Cardiovascular Syncope and Autonomic Disorders
Bangor University
2015-2024
Concept Life Sciences (United Kingdom)
2024
Mayo Clinic in Florida
2020-2023
Gateshead Health NHS Foundation Trust
2020-2022
Imperial College London
2022
Quadram Institute
2022
WinnMed
2020-2022
University of California Davis Medical Center
2022
Northwell Health
2022
University of California, Davis
2022
This paper aims to highlight the importance of exercise in patients with rheumatoid arthritis (RA) and demonstrate multitude beneficial effects that properly designed training has this population. RA is a chronic, systemic, autoimmune disease characterised by decrements joint health including pain inflammation, fatigue, increased incidence progression cardiovascular disease, accelerated loss muscle mass, is, "rheumatoid cachexia". These factors contribute functional limitation, disability,...
Hypoxia, a potent activator of the sympathetic nervous system, is known to increase muscle nerve activity (MSNA) peripheral vasculature native Lowlanders during sustained high altitude (HA) exposure. We show that arterial baroreflex control MSNA functions normally in healthy at HA, and upward resetting permits chronic activation basal vasomotor under this condition. The operating point resting outflow both are lower for highland Sherpa compared acclimatizing Lowlanders; these levels may...
Background: Residual fragments (RFs) after percutaneous nephrolithotomy (PCNL) have a significant impact on patients' quality of life and clinical course. There is paucity studies that evaluate the natural history RFs PCNL. The objective this study to compare rates reintervention, complications, stone growth, passage in patients with >4, ≤4, ≤2 mm Methods: Sites from Endourologic Disease Group for Excellence (EDGE) research consortium examined data PCNL 2015 2019 at least 1-year follow-up....
Heat acclimation induces adaptations that improve exercise tolerance in hot conditions. Here we report novel findings into the effects of ultra-marathon specific load increasing ambient conditions on indices heat acclimation. Six male ultra-endurance runners completed a standard pre-acclimation protocol at 20°C temperature (T amb), followed by consisting six 2 h running exercise-heat exposures (EH) 60% VO2max motorised treadmill an environmental chamber. Three EH were performed 30°C T amb,...
Objectives To compare the enucleation efficiency of Moses 2.0 with non‐Moses technology in patients undergoing holmium laser prostate (HoLEP). Patients and Methods A double‐blinded, randomised study HoLEP at Mayo Clinic Arizona, using Lumenis Pulse™ 120H system. were to either right lobe left non‐Moses, or opposite. The primary outcome was individual efficiency. Secondary outcomes included time, energy, haemostasis energies, fibre burn back. Two independent reviewers watched videos...
Cardio-respiratory fitness (CRF) is a widespread essential indicator in Sports Science as well Medicine. This study aimed to develop and validate prediction model for CRF based on 45 second self-test, which can be conducted anywhere. Criterion validity, test re-test was set up accomplish our objectives. Data from 81 healthy volunteers (age: 29 ± 8 years, BMI: 24.0 2.9), 18 of whom females, were used this against gold standard. Nineteen repeated twice order evaluate its repeatability....
What is the central question of this study? Herein, a methodological overview our research team's (Global REACH) latest high altitude expedition to Peru provided. main finding and its importance? The experimental objectives, organization, measurements key cohort data are discussed. select presented in manuscript demonstrate haematological differences between lowlanders Andeans with without excessive erythrocytosis. also that exercise capacity was similar study groups at altitude. forthcoming...
Cerebral blood flow is known to increase in response hypoxia and decrease with hypocapnia. It not known, however, whether these responses are altered high‐altitude dwellers who only chronically hypoxic hypocapnic, but also polycythaemic. Here we examined cerebral hypocapnia, separately together, Andean dwellers, including some chronic mountain sickness (CMS), which characterized by excessive polycythaemia. Studies were carried out at high altitude (Cerro de Pasco (CP), Peru; barometric...
Orthostatic tolerance is a measure of the ability to prevent hypotension during gravitational stress. It known be dependent on degree vasoconstriction and magnitude plasma volume, but possible influence packed cell volume (PCV) unknown. High altitude residents have high haematocrits probably volumes. However, it not whether blood are affected, or their orthostatic different from low residents. In this study we determined PCV in group dwellers (HA), including subgroup highland with chronic...
Purpose . Exercise tests represent an important clinical tool to evaluate cardio-respiratory fitness and predict future adverse cardiovascular events. However, use of such in patients with rheumatoid arthritis (RA) is relatively uncommon despite well-established evidence that low exercise capacity high CVD mortality are features this disease. Therefore, study examined the validity reliability a sub-maximal step test for RA patients. Methods Thirty (24 females) (mean ± SD age<mml:math...
Abstract The central nucleus of amygdala (CeA) participates in cardiovascular regulation during emotional behaviour but it has not been established whether any these effects are mediated through its direct connections to blood pressure‐regulating neurones the rostral ventrolateral medulla (RVLM). RVLM contains barosensitive that maintain resting pressure via their projections sympathetic preganglionic thoracic spinal cord. In this study on rats, we used combined anterograde neuronal tracing...
High-altitude (>2,500 m) exposure results in increased muscle sympathetic nervous activity (MSNA) acclimatizing lowlanders. However, little is known about how altitude affects MSNA indigenous high-altitude populations. Additionally, the relationship between and blood pressure regulation (i.e., neurovascular transduction) at unclear. We sought to determine 1) effects neurocardiovascular transduction 2) whether differences exist low- Measurements of (microneurography), mean arterial (MAP;...
In an anaesthetised animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation. humans, arterial pressure is positively related to basal muscle sympathetic nerve activity (MSNA) under conditions where elevated evident (e.g. high altitude); however, a causal link not established. Using novel experimental approach, we demonstrate that reducing lowers MSNA healthy humans. This response distinct from negative feedback mediated by aortic and...
<h3>Background</h3> Standardised mortality ratios (SMR) are often used to depict cardiovascular care. Data missingness, data quality, temporal variation and case-mix can, however, complicate the assessment of clinical performance. <h3>Objectives</h3> To study Primary Care Trust (PCT) 30-day SMRs for STEMI NSTEMI whilst considering impact missing age, sex IMD score. <h3>Design</h3> Observational using from Myocardial Ischaemia National Audit Project (MINAP) database generate PCT SMR maps...
Peripheral chemoreflex mediated increases in both parasympathetic and sympathetic drive under chronic hypoxia may evoke bradyarrhythmias during apneic periods. We determined whether 1) voluntary apnea unmasks arrhythmia at low (344 m) high (5,050 altitude, 2) high-altitude natives (Nepalese Sherpa) exhibit similar cardiovagal responses 3) altitude are partially mediated. Participants were grouped as Lowlanders ( n = 14; age 27 ± 6 yr) Nepalese Sherpa 8; 32 11 yr). assessed 344 5,050 m,...
In contrast to the reflex vasodilatation occurring in response stimulation of baroreceptors aortic arch, carotid sinuses and coronary arteries, receptors wall pulmonary arteries results systemic vasoconstriction. It is rare for interventions activate only one reflexogenic region, therefore we investigated how these two types reflexes interact. anaesthetized dogs connected cardiopulmonary bypass, areas sinuses, arch artery were subjected independently controlled pressures. Systemic perfusion...
The University of British Columbia Nepal Expedition took place over several months in the fall 2016 and was comprised an international team 37 researchers. This paper describes objectives, study characteristics, organization management this expedition, presents novel blood gas data during acclimatization both lowlanders Sherpa. An overview framework for forthcoming publications is provided. expedition conducted 17 major studies with two principal goals—to identify physiological differences...
What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation blood pressure in Andean (Quechua) highlanders? main finding its importance? Compared to healthy highlanders, basal vasomotor outflow lower, muscle nerve activity similar, supine heart rate lower cardiovagal gain greater mild CMS. Taken together, these findings reflect flexibility integrative that may be important when viscosity volume are...