A5051931687- Cardiovascular Issues in Pregnancy
- Gestational Diabetes Research and Management
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- High Altitude and Hypoxia
- Pregnancy-related medical research
- Birth, Development, and Health
- Cardiovascular and exercise physiology
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Pregnancy and preeclampsia studies
- Pulmonary Hypertension Research and Treatments
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Infant Development and Preterm Care
- Cardiovascular Syncope and Autonomic Disorders
- Maternal and Perinatal Health Interventions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Maternal Mental Health During Pregnancy and Postpartum
- Ovarian function and disorders
- Artificial Intelligence in Healthcare and Education
- Maternal and fetal healthcare
- Mobile Health and mHealth Applications
- Bariatric Surgery and Outcomes
- Meta-analysis and systematic reviews
University of Alberta
2018-2023
Women and Children’s Health Research Institute
2018-2021
Cardiff Metropolitan University
2013-2020
St Thomas' Hospital
2020
King's College London
2020
Committee on Publication Ethics
2020
Introduction: Depression and anxiety affect one in seven women during the perinatal period, are associated with increased risk of preterm delivery, reduced mother-infant bonding, delays cognitive/emotional development infant. With this survey we aimed to rapidly assess influence COVID-19 pandemic subsequent physical distancing/isolation measures on mental health activity pregnant postpartum women. Methods: Between April 14 – May 8, 2020, recruited who were or within first year after delivery...
Patients with mild chronic obstructive pulmonary disease (COPD) have an elevated ventilatory equivalent to CO2 production ( V̇E / V̇CO2 ) during exercise, secondary increased dead space ventilation. The reason for the is unclear, although microvascular dysfunction and corresponding capillary hypoperfusion a potential mechanism. Despite emerging evidence that COPD associated dysfunction, limited research has focused on experimentally modulating microvasculature exercise in COPD. present study...
What is the central question of this study? Herein, a methodological overview our research team's (Global REACH) latest high altitude expedition to Peru provided. main finding and its importance? The experimental objectives, organization, measurements key cohort data are discussed. select presented in manuscript demonstrate haematological differences between lowlanders Andeans with without excessive erythrocytosis. also that exercise capacity was similar study groups at altitude. forthcoming...
In the general population, functional hemodynamic testing, such as that during submaximal aerobic exercise and isometric handgrip, cold pressor test, has long been utilized to unmask abnormalities in cardiovascular function. During pregnancy, testing places additional demands on an already stressed maternal system. Dysfunctional responses tests early pregnancy may predict development of hypertensive disorders develop later gestation. For each above tests, these recommendations provide a...
High-altitude (>2,500 m) exposure results in increased muscle sympathetic nervous activity (MSNA) acclimatizing lowlanders. However, little is known about how altitude affects MSNA indigenous high-altitude populations. Additionally, the relationship between and blood pressure regulation (i.e., neurovascular transduction) at unclear. We sought to determine 1) effects neurocardiovascular transduction 2) whether differences exist low- Measurements of (microneurography), mean arterial (MAP;...
In an anaesthetised animal model, independent stimulation of baroreceptors in the pulmonary artery elicits reflex sympathoexcitation. humans, arterial pressure is positively related to basal muscle sympathetic nerve activity (MSNA) under conditions where elevated evident (e.g. high altitude); however, a causal link not established. Using novel experimental approach, we demonstrate that reducing lowers MSNA healthy humans. This response distinct from negative feedback mediated by aortic and...
ABSTRACT Introduction Postmenopausal women have lower resting cardiac function than premenopausal women, but whether the menopause influences maximal output and hence exercise capacity is unclear. It possible that postmenopausal achieve similar improvements in aerobic (V˙O 2max ) with training via different regional left ventricular muscle (“LV mechanics”), as suggested by vitro animal studies. The aim of this study was to investigate effects on LV mechanics adaptations training. Methods...
What is the central question of this study? Does chronic mountain sickness (CMS) alter sympathetic neural control and arterial baroreflex regulation blood pressure in Andean (Quechua) highlanders? main finding its importance? Compared to healthy highlanders, basal vasomotor outflow lower, muscle nerve activity similar, supine heart rate lower cardiovagal gain greater mild CMS. Taken together, these findings reflect flexibility integrative that may be important when viscosity volume are...
ABSTRACT Objective To evaluate left ventricular (LV) mechanics in the second trimester of healthy pregnancy and to determine influence underpinning hemodynamics (heart rate (HR), preload afterload) on LV during gestation. Methods This was a cross‐sectional study 18 non‐pregnant, 14 nulliparous pregnant (22–26 weeks' gestation) 13 primiparous postpartum (12–16 weeks after delivery) women. All women had uncomplicated, singleton gestations. Cardiac structure function were assessed using...
The high-altitude maladaptation syndrome known as chronic mountain sickness (CMS) is characterized by polycythemia and associated with proteinuria despite unaltered glomerular filtration rate. However, it remains unclear if indigenous highlanders CMS have altered volume regulatory hormones. We assessed NH 2 -terminal pro-B-type natriuretic peptide (NT pro-BNP), plasma aldosterone concentration, renin activity, kidney function (urinary microalbumin, rate), blood volume, estimated pulmonary...
Early acclimatization to high altitude is characterized by various respiratory, hematological, and cardiovascular adaptations that serve restore oxygen delivery tissue. However, less understood about renal function the role of (RDO 2 ) during acclimatization. We hypothesized 1) RDO would be reduced after 12 h exposure (high day but restored sea level values 1 wk 7) 2) associated with reactivity, an index acid-base compensation at altitude. Twenty-four healthy lowlander participants were...