A5072230359- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Reproductive System and Pregnancy
- Bone Metabolism and Diseases
- Pharmacological Effects of Natural Compounds
- Health and Medical Research Impacts
- Anesthesia and Neurotoxicity Research
- Multiple Sclerosis Research Studies
- Neuroendocrine regulation and behavior
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Neuroscience and Neuropharmacology Research
- Musculoskeletal pain and rehabilitation
- Cancer, Stress, Anesthesia, and Immune Response
- Cytokine Signaling Pathways and Interactions
- Pelvic and Acetabular Injuries
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- Hematological disorders and diagnostics
Kuwait University
2012-2024
American University of Kuwait
2024
Conference Board
2017
Pregnant women with MS experience fewer relapses, especially during the third trimester. In this study, we explore cellular and molecular events that bring about protective effect of late pregnancy on course de/remyelination in rats. Using cellular, molecular, ultrastructural methods, explored remyelination response to a focal demyelination corpus callosum pregnant, virgin, postpartum We further role GABA
To determine prevalence and risk factors of pregnancy-related lumbopelvic pain (PRLPP) in women Kuwait.The study was designed as a multisite, cross-sectional design which self-administered surveys were distributed. Setting Participants. Public locations health care facilities Kuwait. Pregnant (400) invited to participate.Demographics, history PRLPP, for location pain, absenteeism due LPP, management previous functional disability PRLPP.Two hundred eighty questionnaires returned. Mean age...
Abstract Aim Experimental studies have shown that the progesterone metabolite, allopregnanolone, is endowed with promyelinating effects. The mechanisms underlying these effects are not well understood. Therefore, we explored impact of allopregnanolone's synthetic analogue, ganaxolone, on remyelination and microglial activation following focal demyelination in corpus callosum ovariectomized rats. Methods Ovariectomized adult Sprague Dawley rats received a stereotaxic injection 2 µL 1%...
Experimental evidence has shown that the adrenal steroid hormone, androstenediol, dampens symptoms of demyelination. However, cellular and molecular effects androstenediol are not yet known. In present study, we investigated subcellular this hormone in a gliotoxin-induced demyelination model.Male Sprague Dawley rats received 2 μl either saline or gliotoxin ethidium bromide (EB, 0.04%) into corpus callosum. These daily subcutaneous injections oil (5 mg/kg). Their brains were collected at 2,...
Aims: We have previously shown that the neurosteroid androstenediol promotes remyelination following gliotoxin-induced demyelination. However, impact of this on axonal recovery is not yet known. In present study, we investigated integrity a focal demyelination in corpus callosum. Methods: A 2μl solution either ethidium bromide (0.04%) or pyrogen-free saline were stereotaxically injected into callosum Sprague Dawley rats. Each these two rat groups was divided subgroups and received daily...
<b><i>Background/Aims:</i></b> Prenatal exposure to lipopolysaccharide (LPS) dampens hippocampal neurogenesis. This effect is associated with increased anxiety-like behavior in adult offspring. Furthermore, blocking serotonin transporters (SERT) promotes Previous studies were performed largely males. Therefore, we explored the impact of prenatal LPS on neurogenesis, SERT expression hippocampus, and female rats during prepubertal adulthood stages....
Maternal immune activation (MIA) during pregnancy leads to long-lasting effects on brain development and function. Several lines of evidence suggest that the maternal inflammatory cytokine interleukin (IL)-6 plays a crucial role in MIA adult offspring. IL-6 is naturally produced absence any underlying activation. The objective this study was assess whether occurring has plasticity Therefore, pregnant rats were given either an IL-6-neutralizing antibody (IL-6Ab) or vehicle third week...
Summary Aim Brain inflammation is associated with several brain diseases such as multiple sclerosis (MS), a disease characterized by demyelination. Whether prenatal immune challenge affects demyelination‐induced in the white matter during adulthood unclear. In present study, we used well‐established experimental model of focal demyelination to assess whether inflammation. Methods Pregnant rats were injected either lipopolysaccharide (100 μg/kg, ip) or pyrogen‐free saline. A 2 μL solution...
sion.Quantification of neurons stained with NeuN and cresyl violet showed a significant increase in the number anterior posterior horns spinal cord rats from L + TQ group comparison to LO (p < 0.001).Additionally, immunohistochemical examination sections revealed that increased expression GAP-43 Bcl-2 0.001) reduced Bax 0.001).Conclu- sions: We conclude has protective effects on horn motor after peripheral nerve lesion.It may be because antioxidant antiapoptotic TQ.
spring when compared to that seen in female offspring regardless of early-life challenge.There was no apparent effect prenatal exposure LPS on serotonin the raphe nucleus.Interestingly, significantly reduced hippocampal neurogenesis 2-month-old offspring.Such not observed male offspring.Moreover, immune challenge increased expression levels 5HT transporter within hippocampus both and rat offspring.Conclusions: Collectively, these data suggest selectively alters offspring, an accompanied by...