A5075647754- Electrochemical Analysis and Applications
- Analytical Chemistry and Sensors
- Pesticide Exposure and Toxicity
- Biochemical and Molecular Research
- Cholinesterase and Neurodegenerative Diseases
- Electrochemical sensors and biosensors
- Plant Toxicity and Pharmacological Properties
- DNA and Nucleic Acid Chemistry
- Natural product bioactivities and synthesis
- Synthesis and Characterization of Heterocyclic Compounds
- Environmental Toxicology and Ecotoxicology
- Advanced Chemical Sensor Technologies
- Biological Activity of Diterpenoids and Biflavonoids
- Analytical Chemistry and Chromatography
- Click Chemistry and Applications
- Metal complexes synthesis and properties
- Cancer therapeutics and mechanisms
- Botanical Research and Chemistry
- Insect and Pesticide Research
- Synthesis and biological activity
- HIV/AIDS drug development and treatment
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- Heme Oxygenase-1 and Carbon Monoxide
- Carbohydrate Chemistry and Synthesis
Charles University
2002-2025
Purdue University West Lafayette
2025
Czech University of Life Sciences Prague
2025
Vysoká Škola Zdravotníctva a Sociálnej Práce sv. Alžbety
2023
University of Pardubice
2009-2022
Institute of Geography of the Slovak Academy of Sciences
2022
Technical University of Košice
2022
Kuwait University
2008-2021
University of Strathclyde
2020
University of Veterinary Sciences Brno
2006-2014
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Highly sensitive label-free techniques of DNA determination are particularly interesting in relation to the present development sensors. We show that subnanomolar concentrations (related monomer content) unlabeled can be determined using copper solid amalgam electrodes or hanging mercury drop presence copper. is first treated with acid (e.g., 0.5 M perchloric acid), and acid-released purine bases directly by cathodic stripping voltammetry. Volumes 5−3 μL acid-treated easily analyzed, thus...
This is a review of electrodes based on nontoxic solid amalgams (MeSAE) (prepared by amalgamation soft metal powders) in connection with some other kinds voltammetric given. Information summarized various types MeSAEs (esp. AgSAE, CuSAE, AuSAE), pretreatment their surfaces, hydrogen overvoltage aqueous solutions, conditions for testing, electroanalytical parameters and use, compared the hanging mercury drop electrode (HMDE). Although amalgam do not reach quality HMDE, many cases they...
The aim of this study was to assess the effect cypermethrin [(R,S)-α-cyano-3-phenoxybenzyl (1RS)-cis,tra-3-(2,2-dichlorovinyl)-2,2-dimethyl cyclopropane carboxylate] on rainbow trout (Oncorhynchus mykiss). assessed basis results acute toxicity tests and comparison haematological, biochemical histopathological tissue examinations a control experimental group exposed Alimetrine 10 EM pesticide preparation (active substance 100 g/l cypermethrin). semistatical test lasting 96 h performed...
<i>Background:</i> Serum bilirubin is negatively associated with the development of coronary heart disease. In present study, we have focused on analysis intima-media thickness (IMT) common carotid artery in hyper- and normobilirubinemic subjects. <i>Methods:</i> The study was performed 111 men without manifested atherosclerosis. all subjects, complete biochemical tests were determined along examination IMT by ultrasound. <i>Results:</i> mean...
Abstract The preparation, activation and electrochemical pretreatment of electrodes based on nontoxic solid amalgams were described. Testing metal amalgam (MeSAEs) proved their broad applicability in many respects, e.g., as to the range working potentials level background currents, well comparable with those hanging mercury drop electrode (HMDE). A regeneration surfaces before each measurements could be simply automatized using a PC‐controlled system providing reasonable repeatability...
Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1) enzymes, both involved in homeostasis, play an important role the oxidative stress defense. The objective of our study was to assess effect promoter variations HMOX1 UGT1A1 genes serum on risk sporadic colorectal cancer (CRC). This exploratory case-control based 777 CRC patients 986 controls from Czech Republic. (GT)(n) (TA)(n) dinucleotide gene promoters, respectively, were determined by fragment analysis. In...
The preclinical study aimed to compare the healing of segmental bone defects treated with biodegradable hyaluronic acid and tricalcium phosphate-based hydrogel established autologous spongioplasty. Another aim was evaluate as a scaffold for osteoinductive growth factor morphogenetic protein-2 (BMP-2) stem cells. conducted in an vivo animal model. A standardized rabbit model 15 mm long defect left radius used. total 40 animals were divided into 5 groups 8 individuals. In KO- (negative...
Liquid mercury free polished silver solid amalgam electrode (p‐AgSAE) proved experimentally a suitable substitute for the hanging drop in cathodic stripping voltammetric (CSV) analyses of purine bases and acid treated DNA. The are done alkaline solution presence copper(II) ions. With p‐AgSAE using direct current voltammetry (DCV) limits detection as well two types DNA were on nanomol level. Low levels RSD (1–3%, n = 11) repeated measurements confirmed that used mode electrochemical...
At the beginning of 2020, world was swept with a wave new coronavirus disease, named COVID-19 by World Health Organization (WHO 2). The causative agent this infection is severe acute respiratory syndrome 2 (SARS-CoV-2). data available on one promising therapeutic agents—nucleotide analog remdesivir (Gilead Sciences number GS-5734)—were evaluated. These were concerned activation from prodrug to active molecule—triphosphate containing 1′-cyano group and modified nucleobase. This triphosphate...
Abstract The complexation of Cr(III) and Cr(VI) with diethylenetriaminepentaacetic acid (DTPA), the redox behavior these complexes their adsorption on mercury electrode surface were investigated by a combination electrochemical techniques UV/vis spectroscopy. A homogenous two‐step reaction was observed when mixing Cr(III), present as hexaquo complex, DTPA. first product, electroactive 1 : turns into an electroinactive form in second step. results indicate that product is presumably 2...
Mercury meniscus modified solid amalgam electrodes of silver and copper proved experimentally as acceptable substitutes for the hanging mercury drop electrode in highly sensitive cathodic stripping voltammetric analyses nucleic acids their components. Their surfaces can be simply reactivated electrochemically. The are best done weakly alkaline solutions, case copper(II) ions added to solution.