William H. Smith

ORCID: 0000-0003-0226-1979
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About
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Research Areas
  • Cardiac Imaging and Diagnostics
  • Advanced Radiotherapy Techniques
  • Radiation Dose and Imaging
  • Advances in Oncology and Radiotherapy
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Advanced MRI Techniques and Applications
  • Prostate Cancer Diagnosis and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Pancreatic and Hepatic Oncology Research
  • Economic and Financial Impacts of Cancer
  • Prostate Cancer Treatment and Research
  • Head and Neck Cancer Studies
  • Cardiovascular Function and Risk Factors
  • Medical Imaging Techniques and Applications
  • Cardiac Valve Diseases and Treatments
  • Cancer Immunotherapy and Biomarkers
  • Orthopedic Infections and Treatments
  • Cardiac Arrhythmias and Treatments
  • Bacterial Identification and Susceptibility Testing
  • Gastric Cancer Management and Outcomes
  • Hannah Arendt's Political Philosophy
  • Diversity and Career in Medicine
  • Philosophy, Ethics, and Existentialism
  • Cerebral Venous Sinus Thrombosis
  • Diet and metabolism studies

Royal Adelaide Hospital
2011-2025

The University of Adelaide
2025

Icahn School of Medicine at Mount Sinai
2015-2023

Mount Sinai Hospital
2020

University of California, Davis
2011-2017

Film Independent
2017

Seattle University
2010-2017

Nottingham University Hospitals NHS Trust
2014

Nottingham City Hospital
1981-2014

Intuitive Surgical (Switzerland)
2013

Elevated blood branched-chain amino acids (BCAA) are often associated with insulin resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or incomplete BCAA oxidation. White adipose tissue (WAT) has become appreciated as potential player in whole body metabolism. We tested if expression of the mitochondrial oxidation checkpoint, α-ketoacid dehydrogenase (BCKD) complex, is obese WAT regulated by metabolic signals. BCKD protein (E1α subunit) was...

10.1152/ajpendo.00630.2012 article EN AJP Endocrinology and Metabolism 2013-03-20

Ipratropium bromide was given to patients admitted hospital with acute asthma. A cumulative-dose-response technique in six showed that 500 micrograms by nebuliser produced a maximal increase peak expiratory flow rate. This dose of ipratropium included regimen which it either two hours before or after nebulised salbutamol 22 patients. on admission as effective salbutamol. The drugs sequence greater bronchodilatation than used alone, and the mean rate rose 96% four hours. Thus giving addition...

10.1136/bmj.282.6264.598 article EN BMJ 1981-02-21

The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, proper ECM remodeling is critical to support WAT malleability accommodate changes energy storage needs. Obesity adipocyte hypertrophy place a strain on machinery, which may promote disordered altered integrity could proinflammatory cell stress signals. To explore these questions, new methods were developed quantify omental subcutaneous tensile strength collagen...

10.1152/ajpendo.00476.2013 article EN AJP Endocrinology and Metabolism 2013-12-04

Declining inspiratory muscle function and structure systemic low-level inflammation oxidative stress may contribute to morbidity mortality during normal ageing. Therefore, we examined the effects of training (IMT) in older adults on stress, reexamined reported positive IMT respiratory strength, endurance, spirometry, exercise performance, physical activity levels (PAL), quality life (QoL).Thirty-four healthy (68 ± 3 yr) with fitness were divided equally into a pressure-threshold or...

10.1249/mss.0000000000000474 article EN Medicine & Science in Sports & Exercise 2014-08-12

10.1097/00000441-195007000-00002 article EN The American Journal of the Medical Sciences 1950-07-01

Forty-three patients with chronic wrist pain have been investigated prospectively magnetic resonance imaging and arthroscopy. Pathology within the joint was detected in 30 cases 32 The sensitivity specificity of compared arthroscopy were 0.8 0.7 for triangular fibrocartilage complex pathology, 0.37 1.0 scapholunate ligament 0 0.97 lunotriquetral ligament. It is concluded that unhelpful investigation suspected carpal instability. In analysis complex, results should be interpreted caution.

10.1016/s0266-7681(97)80431-7 article EN Journal of Hand Surgery (European Volume) 1997-12-01

99mTc-labeled methoxyisobutyl isonitrile (99mTc-sestamibi) is a myocardial perfusion agent that clears slowly from the myocardium. This study evaluates early and late distributions of 99mTc-sestamibi 201Tl in presence low-flow ischemia to determine whether demonstrates rest "redistribution."Low-flow was produced 18 anesthetized, open-chest dogs by partial occlusion left anterior descending coronary artery. Dogs were injected intravenously with 99mTc-sestamibi, 301Tl, radiolabeled...

10.1161/01.cir.89.5.2332 article EN Circulation 1994-05-01

In Brief Objectives: To describe our initial experience with single-site robotic cholecystectomy (SSRC) and its applicability to a broad segment of patients. Background: At the initiation study, there were only 3 published reports on SSRC. These studies had limited inclusion criteria. We present technical aspects patient outcomes SSRC in broadly inclusive population. Methods: Prospective cohort study from January 2012 2013, which 95 patients underwent Procedural times, postoperative...

10.1097/sla.0000000000000295 article EN Annals of Surgery 2013-10-30

Magnetic resonance (MR) is well suited to imaging the pericardium. High resolution images synchronized with cardiac cycle can be obtained in any plane. The wide field of view allows additional anatomical and functional information from adjacent structures such as aorta, pleura, lungs mediastinum. MR particularly useful cases pericardial constriction without an associated effusion, patients complex or loculated effusions tumours. In this article we illustrate characteristic features a variety...

10.1259/bjr.74.880.740384 article EN British Journal of Radiology 2001-04-01

A real-time magnetic resonance imaging (MRI) acquisition sequence was evaluated for the assessment of left ventricular wall motion (WM) and thickening (WT). Ten normal volunteers 21 patients were studied. Short-axis cine images ventricle (LV) acquired with a fast gradient echo an ultrafast segmented echo-planar (EPI) sequence. Qualitative quantitative analysis WM WT performed on segmental basis. scores agreed between two methods in 691 724 segments (95.4%) good reproducibility. Quantitative...

10.1002/jmri.1146 article EN Journal of Magnetic Resonance Imaging 2001-06-26

The popularity of robotic surgery highlights the need for strategies to integrate this technique into surgical education. We present 5 year data cholecystectomy (RC) as a model training residents.Data were collected on all RC over 66 months. Duration docking robot (S2) and performing (S3), outcomes, recorded. used linear mixed effects investigate learning curves.Thirty-eight trainees performed 160 RCs, with most more than four. One case was aborted due haemodynamic instability, two converted...

10.1002/rcs.1554 article EN International Journal of Medical Robotics and Computer Assisted Surgery 2013-12-04

A study of the necropsy records Massachusetts General Hospital was made to find out number cases with adherent pericarditis. My attention attracted this condition, always difficult diagnosis, by presence extensive pericarditis in two which came quick succession endocarditis so that diagnosis not considered. Out 3,053 necropsies at hospital (1897-1913) there were 62 pericardial adhesions, complete or partial, present. It hoped a these would lead possibly more frequent perhaps explain cause...

10.1001/jama.1913.04350100017006 article EN Journal of the American Medical Association 1913-09-06

10.1097/00000441-191504000-00005 article EN The American Journal of the Medical Sciences 1915-04-01

The following method of staining sputum has grown out a study sputa extending over period three years.During this time most the cases pneumonia, and many bronchitis, entering Massachusetts General Hos- pital, have been studied with especial regard to bacteria present in such cases.Solutions needed : Aniline oil gentian violet.IKI solution, iodine 1, potassium iodide 2, water 300.Saturated aqueous solution eosin'e.Loefller's alkaline méthylène blue.Alcohol, 95%, 4 parts, ether 0 parts.95%...

10.1056/nejm190212181472501 article EN Boston Medical and Surgical Journal 1902-12-18

Background Idiopathic intracranial hypertension (IIH) is a rare condition that can lead to significant morbidity from visual loss. The cause of IIH unknown, but known be associated with obesity. Obese patients may at particularly high risk for suffering vision loss IIH. purpose the present study determine prevalence undiagnosed or asymptomatic papilledema in population morbidly obese individuals and if these should undergo routine screening papilledema. Methods Patients presenting UC Davis...

10.1097/wno.0b013e3182269910 article EN Journal of Neuro-Ophthalmology 2011-07-28

The etiologic relationship of certain forms budding fungi included under the general name of<i>Endomyces</i>has been described by Castellani,<sup>1</sup>who in 1912 called attention to a number chronic bronchial infections Ceylon which tubercle bacilli sputum were never demonstrated. Such sputum, however, constantly contained various yeastlike organisms he divided into several groups. Later,<sup>2</sup>however, enlarged this classification that produced bronchomycosis, and paper refers...

10.1001/jama.1930.02720010018006 article EN Journal of the American Medical Association 1930-07-05
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