A5103011931- Neonatal Respiratory Health Research
- Acoustic Wave Resonator Technologies
- Magneto-Optical Properties and Applications
- Congenital Diaphragmatic Hernia Studies
- Neuroscience of respiration and sleep
- Gyrotron and Vacuum Electronics Research
- Respiratory Support and Mechanisms
- Photonic and Optical Devices
- Nitric Oxide and Endothelin Effects
- Redox biology and oxidative stress
- Advanced Antenna and Metasurface Technologies
- Advanced Optical Sensing Technologies
- Infant Development and Preterm Care
- Microwave Engineering and Waveguides
- Glutathione Transferases and Polymorphisms
- Magnetic properties of thin films
- Drug-Induced Hepatotoxicity and Protection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sulfur Compounds in Biology
- Magnetic Properties and Applications
- Pulsed Power Technology Applications
- Advanced Fluorescence Microscopy Techniques
- Nuclear Physics and Applications
- Electromagnetic Launch and Propulsion Technology
- Virus-based gene therapy research
University of Glasgow
2022-2024
Baylor College of Medicine
1990-2023
University of Washington
2009-2023
University of Arizona
2022
Seattle Children's Hospital
2006-2020
Cold Regions Research and Engineering Laboratory
2019
U.S. Army Engineer Research and Development Center
2019
United States Army
2019
Manchester University NHS Foundation Trust
2018
Washington College
2018
The small-amplitude motions of a plane interface between two fluids stressed by an initially perpendicular electric field are investigated. modeled as Ohmic conductors and the convection surface charge caused dynamic interplay interfacial shear stresses viscous is highlighted. influence viscosity on instability growth rates in zero-shear stress limits perfectly conducting insulating interfaces described compared to cases involving electrical stresses. Detailed attention given having...
Regulation of the biliary excretion reduced glutathione (GSH) and disulfide (GSSG) responses to selected model toxins were examined in male Sprague-Dawley rats. In control phenobarbital-pretreated rats which intrahepatic concentration GSH was modulated by administration diethyl maleate or acetaminophen, consistently lower than, but directly proportional to, GSH. Furthermore, increments bile flow produced infusion sulfobromophthalein (BSP)-glutathione associated with increases GSH, suggesting...
Experiments were designed to test whether the protective effect of N-acetylcysteine against acetaminophen hepatotoxicity precedes arylation tissue or protection occurs after tissue. Investigation potential postarylation actions showed that was unable attenuate liver necrosis caused by several other hepatotoxins act through chemically reactive metabolites. Furthermore, varying time and route treatment indicated late mortality probably a consequence pharmacokinetic factors rather than...
Biological processes are fundamentally driven by complex interactions between biomolecules. Integrated high-throughput omics studies enable multifaceted views of cells, organisms, or their communities. With the advent new post-genomics technologies, becoming increasingly prevalent; yet full impact these can only be realized through data harmonization, sharing, meta-analysis, and integrated research. These essential steps require consistent generation, capture, distribution metadata. To...
Bronchopulmonary dysplasia (BPD) is a chronic lung disease that affects prematurely born infants and appears to evolve in part from early inflammatory responses the lung. The have been associated with protein lipid oxidation tracheal aspirate fluids. present study was designed test hypothesis first week of life specific oxidations and/ or altered expressions proteins would be observed fluids who subsequently develop BPD. We obtained on Days 1, 3, 6 at ⩽ 29 wk gestation, incubated...
Bulky DNA adducts, previously termed type II I-compounds, are detected by 32P-postlabeling following treatment of with several Fenton-type oxygen radical-generating reagents, i.e., mixtures Fe(II) or Ni(II) and H2O2. In an attempt to characterize the chemical nature mechanism(s) formation these novel 16 single-stranded deoxyribooligonucleotides (20- 21-mers) known sequence were oxidized H2O2, products analyzed 32P-postlabeling. Eight adducts obtained reproducibly oxidation test...
Oxidative modification of LDL may be important in the initiation and/or progression atherosclerosis, but precise mechanisms through which low density lipoprotein (LDL) is oxidized are unknown. Recently, evidence for existence HOCl-oxidized human atherosclerotic lesions has been reported, and myeloperoxidase (MPO), thought to act production HOCl, identified lesions. In present report we describe formation 2,4-dinitrophenylhydrazine (DNPH)-reactive modifications apolipoprotein (apo) by...
The insertion loss for multibar magnetostatic-surface-wave (m.s.s.w.) transducers has been calculated from a 'small'-loss microstrip-transmission-line model. Experimental results 2-bar and 8-bar parallel-strip 4-bar π are in excellent agreement with theoretical predictions. parallel-strip-transducer delay line gives major bandpass response at 3.1 GHz, corresponding to an m.s.s.w. wavelength of 300 μm. is 11 dB, the 10 dB bandwidth 70 MHz adjacent sidelobes 16 down.
Lung injury caused by breathing enriched oxygen continues to be a major problem in clinical medicine. Experimentally, hyperoxic lung is characterized pulmonary edema and associated neutrophil accumulation. Although extensively investigated, the mechanisms for accumulation role of this remain controversial. Intercellular adhesion molecule-1 (ICAM-1) an molecule that when increased on endothelium inflammatory cytokines leads neutrophils inflamed transendothelial migration. The purpose study...
Pressures on academic faculty to perform beyond their role as educators has stimulated interest in complementary approaches resident medical education. While fellows are often believed detract from learning and experience, we describe our preliminary investigations utilizing clinical a positive force pediatric Our objectives were implement practical approach engage education, evaluate the impact of fellow-led education program fellow investigate if growth fellowship detracts procedural...
Recent developments in our ability to capture, curate, and analyze data, the field of data-intensive science (DIS), have indeed made these interesting challenging times for scientific practice as well policy making real time. We are confronted with immense datasets that challenge pool, transfer, analyze, or interpret observations. more data available than ever before, yet questions be answered well, no clear path answer them. excited by potential science-based solutions humankind's problems,...
Alkylation of DNA by acetaminophen metabolites has been reported previously, but received little attention, and the biological impact this alkylation is essentially unknown. In present study, apparent covalent binding to in male ICR mice was observed at levels 2.0 ± 0.4 18.5 5.5 pmol acetaminophen/mg liver 0.6 0.1 26.9 2.6 kidney with doses ranging from 10 400 mg/kg. Investigations reaction [3H]-N-acetyl-p-benzoquinone imine (NAPQI) or [ring-14C]NAPQI vitro yielded low alkylation. Greater...
Ion-implanted bars have been used in fabricating magnetostatic surface wave normal incidence reflective array filters at 3.0 GHz. A theory is presented, based on a dispersion relation derived from four layer model, and data taken agrees well with the theory. The ion-implanted provide solution to problems previously associated etched grooves metal bars.
A nondispersive, electronically tunable (165–180 ns) time delay unit based on magnetostatic wave (m.s.w.) propagation with 6% bandwidth at 3 GHz has been demonstrated. The is implemented by cascading surface and backward volume lines designed so that the dispersion slopes are equal opposite in slope over common operating bandwidth; this produces an element constant which can be adjusted a bias field variation of one lines.