A5055318951- Genetic and phenotypic traits in livestock
- Genetic Mapping and Diversity in Plants and Animals
- Veterinary Equine Medical Research
- Human-Animal Interaction Studies
- Veterinary Orthopedics and Neurology
- Animal Genetics and Reproduction
- Genetic diversity and population structure
- Meat and Animal Product Quality
- Animal Behavior and Welfare Studies
- Allergic Rhinitis and Sensitization
- Ruminant Nutrition and Digestive Physiology
- Reproductive Physiology in Livestock
- Genetics and Plant Breeding
- Dermatology and Skin Diseases
- Animal Nutrition and Physiology
- Vector-Borne Animal Diseases
- Hip disorders and treatments
- Genetic Associations and Epidemiology
- Osteoarthritis Treatment and Mechanisms
- Cardiovascular Conditions and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiac Valve Diseases and Treatments
- Exercise and Physiological Responses
- Orthopaedic implants and arthroplasty
- Wheat and Barley Genetics and Pathology
University of Nottingham
2014-2023
Nottingham College
2022
Animal Health Trust
2007-2016
Royal Veterinary College
2016
University of Minnesota
2016
University of Cambridge
2002-2006
University of Liège
1999-2003
Roslin Institute
1997-1999
Abstract We herein report on our efforts to improve the mapping resolution of a QTL with major effect milk yield and composition that was previously mapped bovine chromosome 20. By using denser 20 marker map by exploiting linkage disequilibrium two distinct approaches, we provide strong evidence segment including gene coding for growth hormone receptor accounts at least part effect. sequencing individuals known genotype, identify an F Y substitution in transmembrane domain is associated...
Abstract Detecting genetic signatures of selection is great interest for many research issues. Common approaches to separate selective from neutral processes focus on the variance FST across loci, as does original Lewontin and Krakauer (LK) test. Modern developments aim minimize false positive rate increase power, by accounting complex demographic structures. Another stimulating goal develop straightforward parametric computationally tractable tests deal with massive SNP data sets. Here, we...
Abstract We herein report new evidence that the QTL effect on chromosome 20 in Finnish Ayrshire can be explained by variation two distinct genes, growth hormone receptor (GHR) and prolactin (PRLR). In a previous study Holstein–Friesian dairy cattle an F279Y polymorphism transmembrane domain of GHR was found to associated with milk yield composition. The result our multimarker regression analysis suggests segregate chromosomal region including PRLR. By sequencing coding sequences PRLR...
Detecting genetic signatures of selection is great interest for many research issues. Common approaches to separate selective from neutral processes focus on the variance FST across loci, as does original Lewontin and Krakauer (LK) test. Modern developments aim minimize false positive rate increase power, by accounting complex demographic structures. Another stimulating goal develop straightforward parametric computationally tractable tests deal with massive SNP data sets. Here, we propose...
Summary Many genomic methodologies rely on the presence and extent of linkage disequilibrium (LD) between markers genetic variants underlying traits interest, but LD in horse has yet to be comprehensively characterized. In this study, we evaluate decay a sample 817 Thoroughbreds. Horses were genotyped for over 50 000 single nucleotide polymorphism (SNP) across genome, with 34 848 autosomal SNPs used final analysis. Linkage disequilibrium, as measured by squared correlation coefficient ( r 2...
Abstract The genetic architecture of behavioral traits in dogs is great interest to owners, breeders, and professionals involved animal welfare, as well scientists studying the genetics (including human) behavior. component dog behavior supported by between-breed differences some evidence within-breed variation. However, it a challenge gather sufficiently large datasets dissect basis complex such behavior, which are both time-consuming logistically difficult measure, known be influenced...
Hip dysplasia remains one of the most serious hereditary diseases occurring in dogs despite long-standing evaluation schemes designed to aid selection for healthy joints. Many researchers have recommended use estimated breeding values (EBV) improve rate genetic progress from against hip and elbow (another common developmental orthopaedic disorder), but few empirically quantified benefits their use. This study aimed both determine recent trends dysplasia, evaluate potential improvements...
Inbreeding is inevitable in closed populations with a finite number of ancestors and where there selection. Therefore, management the rate inbreeding at sustainable levels required to avoid associated detrimental effects inbreeding. Studies have shown some pedigree dog breeds high burden inherited disease unrelated selection objectives, implying loss genetic diversity may be particular problem for dogs. Pedigree analysis all 215 currently recognised by UK Kennel Club over period 1980-2014...
Genetic relationships among 37 European cattle breeds were investigated using blood group and serum protein polymorphisms. The 18 859 animals included in the study represented a random sample from pedigree populations UK. Within‐breed variation was estimated by average heterozygosity number of alleles observed, breed evaluated genetic distance. Standard errors heterozygosity, distance obtained bootstrapping. significance differences tested an exact test differentiation. French, Italian...
Stress neuroendocrine systems (hypothalamic-pituitary-adrenal axis and sympathetic nervous system) were studied in 100 female pigs from each of the five main genetic lines used Europe for pork production: Piétrain, Large White, Landrace, Duroc Meishan. Levels cortisol catecholamines measured urine collected at farm, after transportation to slaughterhouse next morning before slaughter. With exception Piétrain line that showed intermediate levels despite its extreme leanness, a significant...
Hip dysplasia is an important and complex genetic disease in dogs with both environmental influences. Since the osteoarthritis that develops irreversible only way to improve welfare, through reducing prevalence, selection. This study aimed evaluate progress of selection against hip dysplasia, quantify potential improvements response via use information increases intensity, prepare for public provision estimated breeding values (EBV) UK. Data consisted 25,243 single records scores Labrador...
Canine hip dysplasia (CHD) is characterised by a malformation of the joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application marker-assisted selection, incorporating specific markers associated with disease, or genomic genome-wide markers, has potential dramatically improve results schemes. Our aims were identify regions its related traits using genome chromosome-wide analysis, study linkage...
Genomic methods have proved to be important tools in the analysis of genetic diversity across range species and can used reveal processes underlying both short- long-term evolutionary change. This study applied genomic investigate population structure inbreeding a common UK dog breed, Labrador Retriever.We found substantial within-breed differentiation, which was associated with role (i.e. working, pet, show) also coat colour black, yellow, brown). There little evidence geographical...
While susceptibility to hypersensitive reactions is a common problem amongst humans and animals alike, the population structure of certain animal species breeds provides more advantageous route better understanding biology underpinning these conditions. The current study uses Exmoor ponies, highly inbred breed horse known frequently suffer from insect bite hypersensitivity, identify genomic regions associated with type I IV reaction. A total 110 cases 170 controls were genotyped on 670K...
Canine atopic dermatitis (cAD) is one the most common and distressing skin disorders seen in dogs. It characterized by dysfunction barrier, with a complex pathogenesis combining both genetic environmental factors.To evaluate associations between factors case-control status two closely related, at-risk breeds, Labrador retriever golden retriever.Two thousand four hundred forty-five pet dogs, of which 793 were classed as cases (575 218 retrievers) 1,652 controls (1,120 532...