A5011445826- Mental Health and Patient Involvement
- Healthcare Decision-Making and Restraints
- Neurobiology and Insect Physiology Research
- Psychiatric care and mental health services
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Interprofessional Education and Collaboration
- Healthcare innovation and challenges
- Employment and Welfare Studies
- RNA Research and Splicing
- Animal Behavior and Reproduction
- Homelessness and Social Issues
- Health disparities and outcomes
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Labor Movements and Unions
- Mental Health Treatment and Access
- Schizophrenia research and treatment
- Cellular Mechanics and Interactions
- Genomics and Chromatin Dynamics
- Family Caregiving in Mental Illness
- Mental Health and Psychiatry
- RNA and protein synthesis mechanisms
- Retinoids in leukemia and cellular processes
- Health Policy Implementation Science
- Mental Health Research Topics
- Community Health and Development
University of Central Lancashire
2015-2024
The Open University
2023
University of Stirling
2023
Edge Hill University
2023
Hesse (Germany)
2023
Austin Health
2020
Illinois Institute of Technology
2016
Faculty of 1000 (United States)
2015
Unison (United Kingdom)
2014
University of California, Berkeley
2010
Abstract In Western society, policy and legislation seeks to minimize restrictive interventions, including physical restraint; yet research suggests the use of such practices continues raise concerns. Whilst international agreement has sought define restraint, diversity in way which countries restraint remains disparate. Research date reported on statistics regarding how why it is used, staff service user perspectives about its use. However, there limited evidence directly exploring...
Abstract ultraspiracle (usp) encodes the Drosophila cognate of RXR, human retinoid X receptor. To examine how RXR subfamily members function in development, we have undertaken a phenotypic analysis usp mutants. is required at multiple stages development for functions that occur wide variety tissues, eye-antennal imaginal disc normal eye morphogenesis and somatic germline tissues adult females fertilization, eggshell embryonic development. An unusual sunken phenotype with marked...
Ataxin 1 (Atx1) is a foci-forming polyglutamine protein of unknown function, whose mutant form causes type spinocerebellar ataxia in humans and exerts neurotoxicity transgenic mouse fly expressing Atx1. In this study, we demonstrate that Atx1 interacts with the transcriptional corepressor SMRT (silencing mediator retinoid thyroid hormone receptors) histone deacetylase 3. binds chromosomes mediates repression when tethered to DNA. Interaction SMRT-related factors conserved feature Atx1,...
Abstract DNA from the scarlet (st) region of Drosophila melanogaster has been cloned by chromosome walking, using breakpoints a new X-ray-induced third inversion (In(3LR)st-a27) which breaks in (73A3.4) and rosy (87D13-14) regions. Two spontaneous mutants st(st1 stsp) contain insertions non-st located within 3.0 kb site breakpoint used to isolate gene, second 6.5 this site. However no changes detectable Southern blotting were found 5 st with cytologically normal chromosomes. A 2.3-kb...
The nucleotide sequences at the 5' end of one actin cDNA and six genomic clones from Dictyostelium have been determined. amino acid derived show strong conservation for seven genes relative to NH2-terminal region Physarum actin. AUG initiating codon is greater than 90% A+T residues in all genes.
Accessible summary What is known on the subject? Mental health nursing in UK and other countries faces an acute workforce crisis. Safe staffing levels are called for, some jurisdictions have been legislated for. The evidence base linking patient outcomes limited. Staffing implicated adverse experiences of service users staff within mental ward settings, they might contribute to violence aggression application restrictive practices, such as physical restraint but there limited research...
The mammalian receptor protein tyrosine kinase (RTK), Anaplastic Lymphoma Kinase (ALK), was first described as the product of t(2;5) chromosomal translocation found in non-Hodgkin's lymphoma. While mechanism ALK activation lymphoma has been examined, to date, no vivo role for this orphan insulin family RTK described.We describe here a novel Drosophila melanogaster RTK, DAlk, which we have mapped band 53 on right arm second chromosome. Full-length DAlk cDNA encodes phosphoprotein 200 kDa,...
A common feature of many human neurodegenerative diseases is the accumulation insoluble ubiquitin-containing protein aggregates in CNS. Although Drosophila has been helpful understanding several disorders, a loss-of-function mutation not identified that leads to CNS aggregates. The study mutations may identify unique components are associated with degenerative diseases. blue cheese (bchs) gene defines such novel pathway. bchs mutants have reduced adult life span age-dependent formation...
Few mutations link well defined behaviors with individual neurons and the activity of specific genes. In Drosophila , recent evidence indicates presence a doublesex -independent pathway controlling sexual behavior neuronal differentiation. We have identified gene, dissatisfaction ( dsf ), that affects sex-specific courtship neural differentiation in both sexes without an associated general behavioral debilitation. Male female mutant animals exhibit abnormalities behaviors, suggesting...
Seven-up (Svp), the Drosophila homolog of chicken ovalbumin upstream transcription factor (COUP-TF); Ultraspiracle (Usp), retinoid X receptor; and ecdysone receptor are all members nuclear/steroid superfamily. COUP-TF negatively regulates hormonal signaling involving in tissue culture systems. Here we demonstrate that Svp, like COUP-TF, can modulate Ultraspiracle-based both vitro vivo. Transfection assays CV-1 cells inhibit ecdysone-dependent transactivation by complex, a heterodimeric...