A5044193643- Advanced biosensing and bioanalysis techniques
- Electrochemical Analysis and Applications
- Fluorine in Organic Chemistry
- Synthesis and Biological Evaluation
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- Molecular Junctions and Nanostructures
- X-ray Diffraction in Crystallography
- Analytical Chemistry and Sensors
- Chemical Reaction Mechanisms
- MicroRNA in disease regulation
- Retinal Development and Disorders
- Phenothiazines and Benzothiazines Synthesis and Activities
- Retinal Diseases and Treatments
- Advanced Biosensing Techniques and Applications
- RNA Interference and Gene Delivery
- Chemical synthesis and pharmacological studies
- Synthesis and Biological Activity
- Retinoids in leukemia and cellular processes
- Carbohydrate Chemistry and Synthesis
- Antioxidant Activity and Oxidative Stress
- Bee Products Chemical Analysis
- Skin Protection and Aging
- Healthcare and Venom Research
- Diatoms and Algae Research
International Medical University
2017-2022
University of Ulster
2018
University of Bath
2013-2017
Northumbria University
2010-2016
You Sheng Chonga, Chun Wai Maib http://orcid.org/0000-0001-6532-184X, Chee Onn Leongc http://orcid.org/0000-0002-6353-9703 & Lai Wongb* http://orcid.org/0000-0003-0236-1275a School of Medicine, International Medical University, Kuala Lumpur, Malaysia; b Department Pharmaceutical Chemistry, Pharmacy, c Life Sciences, Malaysia
Coffee is rich in antioxidant and has been shown to confer various health benefits. Here, we investigated the effect of single-dose coffee consumption healthy human subjects. About 30 volunteers were recruited given a serving sugar free black coffee. Urine fecal samples collected analyzed. Significant changes urinary metabolites relating coffee, gut microbial host energy metabolisms observed post-coffee consumption. Clear sex differences also metabolic profiles pre- Sex richness composition...
Abstract A one-pot synthesis of the trisubstituted imidazole derivatives from α-acetoxy-α-chloro-β-keto-esters, aldehydes, and ammonium acetate has been developed.
MicroRNAs (miRNAs) in blood can act as fingerprints to many diseases including cancer. However, detection of low levels these miRNAs demands for very sensitive techniques. Despite reports available miRNA detection, the methodologies have drawbacks such complexity, use expensive enzymes, etc. We here report a new and simple electrochemical method detect by exploiting intrinsic charges oligonucleotides amplification with positively charged gold nanoparticles (AuNPs). Electrochemical impedance...
Alkynes can be produced by treating some α-bromo ketones with arylsulfonylhydrazines. The reaction is acid-catalysed and mesitylsulfonylhydrazine was the most efficient hydrazine reagent examined. mechanism of has not been elucidated although it shown to proceed via an mesitylsulfonylhydrazone.
Treatment of methyl 2‐aryl‐1,2,3,4‐tetrahydroisoquinoline‐3‐carboxylates 5 with N ‐bromosuccinimide followed by heating in the presence an acid catalyst resulted formation corresponding 2‐aryl‐1,2‐dihydroisoquinoline‐3‐carboxylates 10 via oxidation–dehydration sequence.
A reversed-phase high performance liquid chromatography analytical method with variable wavelength detection was developed for the simultaneous of caffeine and phenolphthalein in weight reducing supplements.Chromatographic separation achieved a C18 column using gradient elution methanol an ammonium acetate buffer (pH 5; 25 mM), detector set at 254 nm.The validated according to The International Conference on Harmonisation Technical Requirements Registration Pharmaceuticals Human Use...
To compare the effect of vegetable oils on uptake lutein and zeaxanthin by adult retinal pigment epithelial (ARPE)-19 cells in vitro.ARPE-19 were cultured Dulbecco's Modified Eagle Medium-F-12 supplemented with 10% foetal bovine serum 1% penicillin-streptomycin a humidified 5% CO2 incubator maintained at 37°C. Cells treated 247 µmol/L lutein, 49 (v/v) either coconut oil, corn peanut olive sunflower soybean castor or linseed oil for 48h. Lutein concentration quantified high performance liquid...