A5035116488- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Advanced ceramic materials synthesis
- Dental materials and restorations
- Orthopaedic implants and arthroplasty
- Periodontal Regeneration and Treatments
- T-cell and B-cell Immunology
- biodegradable polymer synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Chemical Synthesis and Characterization
- Oral and gingival health research
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Liver physiology and pathology
- Phytase and its Applications
- Organ Transplantation Techniques and Outcomes
- Thermal and Kinetic Analysis
- Immune Cell Function and Interaction
- Tissue Engineering and Regenerative Medicine
- Bone health and osteoporosis research
- Advanced materials and composites
- Nanoparticles: synthesis and applications
- Titanium Alloys Microstructure and Properties
Meiji University
2016-2025
Royal Society of Chemistry
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Pfizer (Japan)
2023
Fukuoka International University
2017
International University of Health and Welfare
2017
Argonne National Laboratory
2013-2015
Kanagawa Academy of Science and Technology
2011-2014
Tohoku University
1963-2013
Sci-Tec (United States)
2012
Abstract To prevent infections associated with medical implants, various antimicrobial silver-coated implant materials have been developed. However, these do not always provide consistent antibacterial effects in vivo despite having dramatic vitro, probably because the involve silver-ion-mediated reactive oxygen species generation. Additionally, silver application process often requires extremely high temperatures, which damage non-metal materials. We recently developed a bacteria-resistant...
Hydroxyapatite and β-tricalcium phosphate have been clinically applied as artificial bone materials due to their high biocompatibility. The development of bones requires the verification safety efficacy through animal experiments; however, from viewpoint welfare, it is necessary reduce number experiments. In this study, we utilized machine learning construct a model that estimates bone-forming ability bioceramics material fabrication conditions, properties, in vivo experimental conditions....
Abstract Whether Propionibacterium acnes ( P. ) causes surgical-site infections (SSI) after orthopedic surgery is controversial. We previously reported that we frequently find in intraoperative specimens, yet none of the patients have clinically apparent infections. Here, tracked for 6 months a mouse osteomyelitis model. inoculated with an implant into femur group; control group was treated bacteria but no implant. then observed over 6-month period using optical imaging system. During first...
Abstract Various silver-coated implants have been developed to prevent implant-associated infections and shown dramatic effects in vitro . However, the vivo results inconsistent. Recent studies showed that silver exerts antibacterial activity by mediating generation of reactive oxygen species presence oxygen. To maintain its , should remain an ionic state be stably bound implant surface. Here, we a novel bacteria-resistant hydroxyapatite film which is immobilized via inositol hexaphosphate...
By using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE), we investigated the difference in HLA class II molecule between HLA-Dw2 and Dw12, both of which are typed as HLA-DR2 serologically. The anti-HLA-DR framework monoclonal antibody (MoAb) HU-4 precipitated an alpha-chain two beta-chains human molecules from Dw2 Dw12 homozygous B lymphoblastoid cell lines. It was demonstrated clearly that (alpha 1) one (beta showed no mobility 2D-PAGE but another beta chain 2) distinct...
ABSTRACT Osteomyelitis remains a serious problem in the orthopedic field. There are only few animal models which quantity and distribution of bacteria can be reproducibly traced. Here, we established real-time quantitative mouse model osteomyelitis using bioluminescence imaging (BLI) without sacrificing animals. A bioluminescent strain Staphylococcus aureus was inoculated into femurs mice. The bacterial photon intensity (PI) then sequentially measured by BLI. Serological histological...
We developed a novel antibacterial implant by forming hydroxyapatite (HAp) film on polyetheretherketone (PEEK) substrate, and then immobilizing silver ions (Ag(+) ) the HAp based chelate-bonding ability of inositol phosphate (IP6). First, PEEK surface was modified immersion into concentrated sulfuric acid for 10 min. formed acid-treated via soft-solution process using simulated body fluid (SBF), urea, urease. After coating, specimens were immersed IP6 solution, followed nitrite solution at...
ABSTRACT To investigate the effects of crosslinker density on properties hydrogels, compression tests, scanning electron microscopy (SEM), differential calorimetry (DSC), and Raman measurements were performed poly‐ N , ‐dimethylacrylamide hydrogels. The results tests showed that Young's modulus increases as increases. understand mechanism change in mechanical properties, structures polymer networks water molecular vibrations analyzed using SEM, DSC, methods. From SEM images, it was found...
The Pirarubicin Monotherapy Study Group trial was a randomized Phase II study that evaluated the efficacy of intravesical instillation pirarubicin in prevention bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma. This conducted further analysis cohort, focusing on seeding cancer cells. Using data from trial, recurrence-free survival rates and factors associated with control group were analyzed. Of 36 patients group, 14 positive urine cytology had more...
Calcium-phosphate cement (CPC), commonly used as a bone graft substitute, sets hydroxyapatite (HAp) and remains in the body for extended periods. To enhance bioresorbabability, we developed chelate-setting tricalcium β-phosphate (β-TCP) using inositol phosphate (IP6) surface modification. By incorporating poly(lactic-co-glycolic acid) (PLGA) particles pore-forming agent calcium sulfate hemihydrate (CSH) to this CPC, created an organic/inorganic hybrid combining bioresorbability with...
Murine monoclonal antibodies (MoAb) to three distinct Ia-like molecules were studied for their inhibitory effects on antigen- and alloantigen-induced T cell proliferations. The MoAb classified into groups according the they recognized. Both group I reacting with DR III capable of inhibiting proliferative responses PPD- HSV-Ag-pulsed APC, autologous B-LCL, alloantigens. On th other hand, II MoAb, which reacted a determinant molecule carrying MB1 determinants, was only These results suggest...
A novel synthetic route to peptide-capped gold nanoparticles was demonstrated herein. Tetrachloroaurate ions were reduced with 2-[4-(2-hydroxyethyl)-1-piperazinyl]ethanesulfonic acid (HEPES) under extremely mild conditions (pH 7.2, ambient temperature) in the presence of cysteine-terminal desired peptides, so that spherical successfully synthesized. Model basic peptides containing Arg-Pro-Thr-Arg sequence, which is an essential motif specifically binds film surfaces composed isotactic...