A5087529777- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Phagocytosis and Immune Regulation
- MicroRNA in disease regulation
- Primate Behavior and Ecology
- Axon Guidance and Neuronal Signaling
- Erythrocyte Function and Pathophysiology
Broad Institute
2019-2025
Massachusetts Institute of Technology
2019-2024
McGovern Institute for Brain Research
2019-2023
Dimagi (United States)
2022
The mammalian brain is composed of many structures, each with its own ontogenetic and developmental history. We used single-nucleus RNA sequencing to sample over 2.4 million cells across 18 locations in the common marmoset, a New World monkey primed for genetic engineering, examined gene expression patterns cell types within structures. adult transcriptomic identity most neuronal shaped more by origin than neurotransmitter signaling repertoire. Quantitative mapping GABAergic single-molecule...
ABSTRACT Primates and rodents, which descended from a common ancestor more than 90 million years ago, exhibit profound differences in behavior cognitive capacity. Modifications, specializations, innovations to brain cell types may have occurred along each lineage. We used Drop-seq profile RNA expression 184,000 individual telencephalic interneurons humans, macaques, marmosets, mice. Conserved interneuron varied significantly abundance between mice primates, but much modestly among primates....
Abstract The mammalian brain is composed of many structures, each with its own ontogenetic and developmental history. Transcriptionally-based cell type taxonomies reveal composition similarity relationships within across structures. We sampled over 2.4 million cells 18 locations in the common marmoset, a New World monkey primed for genetic engineering, used single-nucleus RNA sequencing to examine global gene expression patterns types Our results indicate that there generally high degree...
Astrocytes are an abundant class of glial cells with critical roles in neural circuit assembly and function. Though many studies have uncovered significant molecular distinctions between astrocytes from different brain regions, how this regionalization unfolds over development is not fully understood. We used single-nucleus RNA sequencing to characterize the diversity across six developmental stages four regions mouse marmoset brain. Our analysis 170,000 single astrocyte nuclei revealed...