Abstract Background Synthesis of oximes is an important reaction in organic chemistry, because these versatile are used for protection, purification, and characterization carbonyl compounds. Nitriles, amides via Beckmann rearrangement, nitro compounds, nitrones, amines, azaheterocycles can be synthesised from oximes. They also find applications selective α -activation. In inorganic act as a ligand. Several procedures the preparation exist, but, most them have not addressed green chemistry...

Abstract A short library of symmetrical bis-imines has been constructed efficiently from the reaction between dialdehydes and mono amines or diamines aldehydes under microwave irradiation catalyzed by p-toluenesulphonic acid. The methodology is associated with shorter time, good yields simple workup.

ZrOCl2˙8H2O is a highly effective, water-tolerant, and reusable catalyst for the direct condensation of carboxylic acids N,N′-dimethylurea under microwave irradiation to give corresponding N-methylamides in moderate excellent yields. Notably, potentially useful green due its low toxicity, easy availability, cost, ease handling, recovery, good activity, reusability.

Seven numbers of sulfonic acid functionalized imidazolium salts (ionic liquids) have been tested for the synthesis pyrido[2, 3-d:6,5-d]dipyrimidine-2,4,6,8-tetrone derivative with completely aromatic pyridine ring. [Dsim]Cl is found to be best among them carry out via condensation 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione aldehydes within minutes under microwave irradiation, paving way an excellent methodology towards a series 3-d:6,5-d]dipyrimidine-2,4,6,8-tetrone. The catalyst can...

Abstract Less-toxic, moisture-stable, inexpensive, and ecofriendly zirconium oxychloride octahydrate (ZrOCl2 · 8H2O) in aqueous acetone (1:1) mediates the conversion of oximes to carbonyl compounds moderate good yields. This green methodology is applicable both aldoximes ketoximes with tolerance >C˭C<, -NO2, -OH, -Cl groups. The reaction workup are simple.

KI‐VO(acac) 2 ‐H O in aqueous ethanolic medium with acetic acid as additive has been found to iodinate pyrimidinediones and aromatic amines. The methodology is mild, efficient, environmentally benign. Density functional theory‐based reactivity parameters support the experimentally observed of pyrimidinedione derivatives.

A new polymeric copper complex ([Cu 3 (DMAP) 8 (μ -CO ) 2 ]I n · x H O is synthesized, characterized and used in C–O C–S cross coupling reactions for the synthesis of biologically important phenoxypyrimidine arylthiopyrimidine scaffolds.

The title compound, C(19)H(21)ClN(6)O(4), is a 1:2 adduct of p-chloro-benzaldehyde and uracil. It crystallizes with two mol-ecules in the asymmetric unit. uracil units same mol-ecule are connected by pair strong N-H⋯O hydrogen bonds. packing stabilized N-H⋯O, C-H⋯O C-H⋯N inter-actions.

Abstract Available procedures for Michael addition reaction of homoaromatic C−H nucleophiles ( N,N ‐dialkylanilines and their cyclic analogues) with nitrostyrenes are observed to be very time consuming (18‐72 h). So, a gentle effort has been made reduce the requirement, which is reported herein. Our developed methodology makes use commercially available Fe(OTf) 3 as an efficient catalyst (5 mol%) under microwave irradiation (700 W, 120 °C) solvent‐free condition found capable furnishing...

In recent years, magnetically active CuFe 2 O 4 nanoparticles have been gaining significant interest in the field of heterogeneous catalysis as those can be easily prepared and effortlessly recovered from a reaction system. Here, we are reporting our work on cascade syntheses 1,3‐dimethyl‐6‐nitro‐5‐arylpyrido[2,3‐ d ]pyrimidine‐2,4(1 H ,3 )‐diones starting 6‐[(dimethylamino)methylene‐amino]‐1,3‐dimethyluracil, aromatic aldehydes nitromethane using catalyst system under microwave irradiation...

Sodium triacetoxyborohydride [Na(OAc)3BH, abbreviated as STAB-H] is a versatile reagent in organic synthesis. In addition to its superior ability effecting reductive amination of aldehydes and ketones, it can reduce N-heterocycles (indoles, quinolines, isoquinolines), imines, enamines, oximes, amides, aryl acetals, other substrates. [¹]

This letter describes the first synthetic methodology for phenoxypyrimidines that avoids direct use of phenols or their salts. In contrast to general trend delivering Suzuki–Miyaura cross-coupling products in reactions between aryl alky halides and arylboronic acids, substrate pairs used herein (chloropyrimidines acids) led C–O bond formation under reaction conditions. total, 25 were successfully synthesized using described protocol, 6 which had a structural resemblance etravirine.

Abstract Available synthetic protocols for 3,5‐diaryl‐1 H ‐pyrazoles generally demand long reaction time. Herein, we are reporting a CuFe 2 O 4 catalyzed procedure the same that delivers products in significantly reduced time starting from tosylhydrazones of aromatic aldehydes and terminal alkynes. Under condition, tosylhydrazone generates diazo compound situ, which then undergoes [3 + 2] cycloaddition with alkyne followed by [1,3]‐H shift to deliver final 72%–85% isolated yield....

Abstract A one‐pot version of the catalyst‐free and regioselective synthesis (V) from (I) with lower yields is also described.

Abstract The method involves the Michael type addition of various nitrostyrenes to pyrimidinone (I) and subsequent reductive cyclization adduct utilizing strong reducing nature an alkaline Na 2 S O 4 solution combined with fact that medium favors addition.

Abstract A simple, selective, mild, and environmentally‐friendly method for the selective monoiodination of activated pyrimidinediones aromatic amines is developed.