A synthetic strategy of a palladium-catalyzed cascade annulation reaction followed by aerial oxidation was designed to construct 6H-benzo[c]chromene scaffolds. Various 6H-benzo[c]chromenes were synthesized under mild conditions using easily accessible p-QMs and commercially available o-hydroxyarylboronic acids. One the chromenes has been ambiguously confirmed single-crystal XRD analysis. Interestingly, our could be transformed into valuable 6H-benzo[c]chromen-6-ones via oxidation.

The synthesis and characterization of a pincer-nickel complex the type (iPr2NNN)NiCl2(CH3CN) is reported here. We have demonstrated utility this (0.02 0.002 mol %) for catalytic N-alkylation amines using various alcohols. Under solvent-free conditions, while highest yield (ca. 90%) was obtained alkylation 2-aminopyridine with naphthyl-1-methanol, excellent turnovers (34000 TONs) were observed 4-methoxybenzyl alcohol. To demonstrate synthetic these systems, high-yield reactions (up to 98%)...

Abstract The “borrowing hydrogen” (BH) method for C‐alkylation reactions using alcohol as alkylating agents is an important synthetic transformation. In this respect, designing cheap and bench stable earth abundant metal catalyst borrowing hydrogen transformation a key challenge to be witnessed. Herein we have presented synthesis of non‐phosphine, easily accessible SNS−Ni complexes. Ni‐catalyst was successfully applied the ketone enolates α‐alkylated ketones. Primary with different...

In this study, a sustainable and eco-friendly copper-free protocol has been developed for the regioselective synthesis of 1,4-disubstituted N -unsubstituted 1,2,3-triazoles using zinc-based heterogeneous catalyst.

An environmentally benign protocol has been developed for the synthesis of two biologically important N-heterocycles i.e. 2,3-dihydroquinazolin-4(1H)-ones and NH-1,2,3-triazoles. These N-heterocyclic compounds are synthesized by readily available inexpensive LiClO4 in ethylene glycol (EG) PEG-400 with good to excellent product yield providing an benchmark rapid these heterocycles under operational simplicity. Sc-XRD one products gives structural information DFT calculations provide on...

Sarcochlamys pulcherrima (Roxb.) Gaudich is a small, traditionally used medicinal plant belonging to the Urticaceae family. The leaves of are commonly consumed by different tribes inhabiting North‐Eastern states India. This work involves dereplicating ethanolic leaf extract S. pulcherrima, leading isolation two new steroidal compounds‐ SP‐C1 and SP‐C2‐ characterised single crystal X‐ray diffraction analysis. compound SP‐C2 displayed significant antioxidant properties with an IC50 value 4.75...

A Pd(II)-catalyzed cascade annulation of 4-hydroxy-3-maleimidecoumarin with alkynes has been demonstrated. This unique strategy highlights an interesting process for the formation three rings (three-, five-, and six-membered) carbocycles heterocycles through spiro-annulation followed by cyclization. offers attractive platform synthesizing various coumarin-fused complex structures in good yields. Additionally, six synthesized compounds have unambiguously confirmed single-crystal X-ray...

A novel transition-metal-free direct synthesis of 3-substituted isocoumarin from 4-hydroxycoumarin and a benzyne precursor is developed. This synthetic strategy proceeds via C–O C–C bond cleavage as well formations in single reaction vessel by simple treatment with CsF the absence catalyst. methodology affords moderate to good yields isocoumarins tolerant variety functional groups including halide.

A transition-metal-free coupling reaction of aryne, DMSO, and activated alkyne for the synthesis 2-[( o-methylthio)aryloxy]-substituted dialkyl maleates is reported. This cascade process associated with several bond cleavage as well formation reactions in one pot. One our synthesized has been unambiguously established by single-crystal XRD studies. methodology allows preparation trisubstituted vinyl ethers excellent stereospecificity.

Abstract A series of NNN pincer‐ruthenium complexes ( R2 NNN)RuCl 2 (PPh 3 ) (R=Cyclohexyl (Cy), t ‐butyl Bu), i ‐propyl Pr) and phenyl (Ph)) have been synthesized characterized. These used to catalyse the Kharasch addition or atom transfer radical (ATRA) carbon tetrachloride styrene. Among catalysts screened for addition, catalytic activity followed order Cy2 )>( Pr2 )≫( Ph2 ). The oxidation Ru(II) is easier with in comparison RuCl as indicated by cyclic voltammetry studies. catalyst...

A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C-O and C-C bond cleavage as well formation in a single vessel. The methodology provides good yields tolerates variety functional groups. synthesized were further benzoylated at 3-positions one 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.

A synthetic strategy for pyrrolo[3,4-<italic>c</italic>]quinoline-1,3-diones<italic>via</italic>oxidative annulation followed by DDQ mediated dehydrogenation and<italic>N</italic>-demethylation.

High TONs and TOFs are observed for the β-alkylation of alcohols using phosphine-free pincer-ruthenium catalysts at a very low base loading. Kinetic studies DFT calculations were complementary provide clear understanding on mechanism.

Abstract An efficient photocatalyst‐free visible light enabled synthesis of substituted pyrroles from α‐keto vinyl azides (readily prepared via Knoevenagel condensation phenacyl with 2‐oxo‐2 H ‐chromene‐3‐carbaldehydes) was developed. The reaction proceeds through a denitrogenative photodecomposition azides, 1,3‐amino group migration, and coupling intermediates secondary amines. magnified image

Caffeine (caf) forms co-crystals caf·dpa (1), caf·pzca (2) and 2caf·trimel (3) with dipicolinic acid (dpa), 3,5-pyrazole dicarboxylic (pzca), trimellitic (trimel), respectively, whereas theophylline formed theo·2dpa (4) 2theo·2pzca (5) the first two acids. These are characterized by X-ray diffraction conventional spectroscopic techniques. Co-crystal 1 a hydrogen-bonded assembly through one of carboxylic acids imidazole moiety caffeine, other group is involved in strong hydrogen bonding...

Multicomponent crystals (either cocrystal or salt) of nicotinamide (nicotinic acid amide) and isonicotinamide with various nitrogen heterocycle-containing aromatic dicarboxylic acids, namely, 3,5-pyrazole (pzdca), dipicolinic (dpa), quinolinic (qna), have been synthesized characterized by single-crystal diffraction thermal studies. The (nic) (isonic) cocrystals (1 2, respectively) possess four different heteromeric supramolecular synthons in each cocrystal, which is rare. 3, showed formation...

A dicarboxamide based nickel complex with an internal quinoline moiety, acts as active photocatalyst for proton reduction achieving 2160 turnovers. The pendant base functions relay towards the metal center to generate H₂following a CECE (C = Chemical, E Electrochemical) mechanistic path.

The interconversion of the binuclear copper complex <bold>[Cu(DQPD)]2</bold> to mononuclear [Cu(DQPD)]⁺ has been studied and their catalytic behaviour towards proton reduction reported.

The first denitrative Pd( ii )-catalyzed alkyne annulation reaction is reported for the synthesis of cyclopenta[ b ]chromanes.