Alexander W. Koch

ORCID: 0000-0003-0255-9724
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About
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Research Areas
  • Optical measurement and interference techniques
  • Surface Roughness and Optical Measurements
  • Advanced Measurement and Metrology Techniques
  • Optical Polarization and Ellipsometry
  • Liver Diseases and Immunity
  • Thermography and Photoacoustic Techniques
  • Sensor Technology and Measurement Systems
  • Ultrasonics and Acoustic Wave Propagation
  • Liver Disease Diagnosis and Treatment
  • Advanced Optical Sensing Technologies
  • Structural Health Monitoring Techniques
  • Adaptive optics and wavefront sensing
  • Optical Coherence Tomography Applications
  • Advanced Surface Polishing Techniques
  • Image and Object Detection Techniques
  • Liver Disease and Transplantation
  • Medical Image Segmentation Techniques
  • Brain Tumor Detection and Classification
  • Advanced Neural Network Applications

RWTH Aachen University
2025

Technical University of Munich
2011-2023

Humboldt-Universität zu Berlin
2022

Charité - Universitätsmedizin Berlin
2022

Freie Universität Berlin
2022

Abstract Background Patients with acute decompensation (AD) of cirrhosis are at high risk developing acute-on-chronic liver failure (ACLF), a syndrome characterized by multiple organ and short-term mortality. This study aimed to analyse alterations in peripheral blood mononuclear cells (PBMCs) patients AD using single-cell technologies explore their implications for stratification prognosis. Methods A total 63 15 healthy donors were enrolled five European centers, samples collected upon...

10.1101/2025.02.04.25321370 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2025-02-07

A real-time, dual-sensitive shearography system using a single-wavelength laser was developed for simultaneous and dynamic in-plane out-of-plane strain measurements. The is capable of measuring crack-tip deformation fields quantitatively. spatial multiplexing technique based on Fourier transform employed multi-component phase retrieval. Two slit filters common-path shearing interferometer are used to obtain an improved quality Mode-I fracture experiments under three-point bending were...

10.1364/oe.27.003276 article EN cc-by Optics Express 2019-01-30

In this paper, a quantification of the influence roughness in phase-shifting speckle technique (phase-difference) is presented. For purpose, series experiments were carried out on calibrated samples different varying equivalent wavelength Λ, by combining wavelengths an argon-ion laser. order to use method correctly, basis phase fringe contrast, criterion for minimal Λ (limit) needed specific given. Besides, considering investigated relation between and effective as inverse problem, procedure...

10.1063/1.4861909 article EN Review of Scientific Instruments 2014-01-01

Laser spot detection is an important step of laser triangulation and limits its accuracy. Common methods to determine the center position include circle fitting, Hough transformation, gray centroid method or Gaussian fitting. As these algorithms were often tested in different set-ups under various conditions, they generally lead diverse results. The aim this contribution investigate a more objective realistic approach. After short introduction triangulation, basic information about given....

10.1117/12.2525669 article EN Optical Measurement Systems for Industrial Inspection XI 2019-06-21

Due to the modulo-2π periodicity of interferometric principle and diffraction occurring at steep surface height variations, electronic speckle-pattern interferometry (ESPI) is restricted generally continuous surfaces with minor structural density. With a dynamic reference wavefront adapted measurement object, resolution or filigree areas feasible. The problems generation high-resolution wavefronts (HRDWs) will be discussed, new method for realization presented. This paper shows first...

10.1117/12.2189471 article EN Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE 2015-08-24

Two-wavelength speckle interferometry (SI) is widely used for shape measurements of rough surfaces. A surface under test arranged in an interferometer illuminated with laser light having two different wavelengths. In the most simplified case interferograms are intensity-subtracted where fringe distance detected pattern provides information about difference height corresponding positions surface. The between fringes can be associated synthetic wavelength Λ, equivalent to envelope a beat...

10.1117/12.870003 article EN Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE 2010-08-25

Numerous processes, e.g. in semiconductor and optics producing industries require film thickness observation. These measuring systems depend on different working principles, spectral reflectometry or ellipsometry. The interrogation method can be evaluated by various algorithms depending resolution range demanded. All methods a broad distribution of the light source order to sample signal sufficiently for parameter extraction. Spectral sampling is often realized using spectroscope, which...

10.1117/12.827537 article EN Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE 2009-05-11

Abstract Ständig steigende Anforderungen an die Qualitätsprüfung in der industriellen Fertigung erfordern neue Verfahren zur schnellen und zerstörungsfreien Oberflächenprüfung. Für Formvermessung technischer Oberflächen bietet sich hierfür Zwei-Wellenlängen-Technik Speckle-Interferometrie an. Die bisher sehr hohe Störempfindlichkeit interferometrischer Messungen auf erschütterungsbedingte Bewegungen des Messobjektes sowie eine lange Rechenzeit Auswertung Interferogramme ließen industrielle...

10.1524/teme.70.2.93.20111 article DE tm - Technisches Messen 2003-02-01

Die Speckle-Interferometrie ist eine berührungslose Lasermesstechnik an technischen, optisch rauen Oberflächen. Das Phase-Shifting-Verfahren liefert dreidimensionale Informationen, z.B. von Deformationen oder Oberflächenformen. Im Gegensatz zum zeitlichen Phase-Shifting erlaubt das räumliche Messungen nicht schwingungsgedämpften Messobjekten, indem mehrere phasenverschobene Speckle-Bilder gleichzeitig aufgenommen werden. Der hier vorgestellte Messaufbau ermöglicht es, mit vier Kameras...

10.1524/teme.2000.67.4.155 article DE tm - Technisches Messen 2000-04-01
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